Christof Koch
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View article: Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem
Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem Open
Electrical stimulation of nervous tissue is grounded in well-established biophysical principles, yet understanding its precise effect on neural activity remains challenging. This represents a major obstacle to both scientific and clinical …
View article: Map of spiking activity underlying change detection in the mouse visual system
Map of spiking activity underlying change detection in the mouse visual system Open
Visual behavior requires coordinated activity across hierarchically organized brain circuits. Understanding this complexity demands datasets that are both large-scale (sampling many areas) and dense (recording many neurons in each area). H…
View article: Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings
Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings Open
To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single-neuron and single-spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons…
View article: Evidence from spatial transcriptomics for the mosaic hypothesis and pure cell types in the cortex
Evidence from spatial transcriptomics for the mosaic hypothesis and pure cell types in the cortex Open
Neurons display remarkable diversity in their anatomical, molecular, and physiological properties. Although observed stereotypy in subsets of neurons is a pillar of neuroscience, clustering in high-dimensional feature spaces, such as those…
View article: Covert consciousness: what’s in a name?
Covert consciousness: what’s in a name? Open
Over the past decade, it has become apparent that up to 25% of behaviourally unresponsive patients with acute or chronic disorders of consciousness reveal high spatio-temporal complexity following a direct electrical or magnetic pulse to t…
View article: The void and the brain
The void and the brain Open
Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryptamine, revealing profoundly slowed-down brain activity but no significant reduction of alph…
View article: Deciphering neuronal variability across states reveals dynamic sensory encoding
Deciphering neuronal variability across states reveals dynamic sensory encoding Open
Influenced by non-stationary factors such as brain states and behavior, neurons exhibit substantial response variability even to identical stimuli. However, it remains unclear how their relative impact on neuronal variability evolves over …
View article: Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics
Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics Open
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations, and is especially powerful when combined with optogenetics for manipulation of specific cell types with high tem…
View article: Dissociating Artificial Intelligence from Artificial Consciousness
Dissociating Artificial Intelligence from Artificial Consciousness Open
Developments in machine learning and computing power suggest that artificial general intelligence is within reach. This raises the question of artificial consciousness: if a computer were to be functionally equivalent to a human, being abl…
View article: Spatial transcriptomic data reveals pure cell types via the mosaic hypothesis
Spatial transcriptomic data reveals pure cell types via the mosaic hypothesis Open
Neurons display remarkable diversity in their anatomical, molecular, and physiological properties. Although observed stereotypy in subsets of neurons is a pillar of neuroscience, clustering in high-dimensional feature spaces, such as those…
View article: Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem
Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem Open
Electrical stimulation of nervous tissue is grounded in well-established biophysical principles, yet understanding its precise effect on neural activity remains challenging. This represents a major obstacle to both scientific and clinical …
View article: Cell-class-specific electric field entrainment of neural activity
Cell-class-specific electric field entrainment of neural activity Open
Electric fields affect the activity of neurons and brain circuits, yet how this happens at the cellular level remains enigmatic. Lack of understanding of how to stimulate the brain to promote or suppress specific activity significantly lim…
View article: Testing the Conjecture That Quantum Processes Create Conscious Experience
Testing the Conjecture That Quantum Processes Create Conscious Experience Open
The question of what generates conscious experience has mesmerized thinkers since the dawn of humanity, yet its origins remain a mystery. The topic of consciousness has gained traction in recent years, thanks to the development of large la…
View article: Transition to chaos separates learning regimes and relates to measure of consciousness in recurrent neural networks
Transition to chaos separates learning regimes and relates to measure of consciousness in recurrent neural networks Open
Recurrent neural networks exhibit chaotic dynamics when the variance in their connection strengths exceed a critical value. Recent work indicates connection variance also modulates learning strategies; networks learn ”rich” representations…
View article: Deciphering neuronal variability across states reveals dynamic sensory encoding
Deciphering neuronal variability across states reveals dynamic sensory encoding Open
Influenced by factors such as brain states and behavior, neurons exhibit substantial response variability even to identical stimuli. Because these factors are non-stationary, they dynamically impact the fidelity of sensory processing. Howe…
View article: Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex Open
In complex environments, animals can adopt diverse strategies to find rewards. How distinct strategies differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinh…
View article: Testing the Conjecture That Quantum Processes Create Conscious Experience
Testing the Conjecture That Quantum Processes Create Conscious Experience Open
The question of what generates conscious experience has mesmerized thinkers since the dawn of humanity, yet its origins remain a mystery. The topic of consciousness has gained traction in recent years, thanks to the development of large la…
View article: Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans
Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans Open
Cortical stimulation with single pulses is a common technique in clinical practice and research. However, we still do not understand the extent to which it engages subcortical circuits which contribute to the associated evoked potentials (…
View article: Robustness against Read Committed for Transaction Templates with Functional Constraints
Robustness against Read Committed for Transaction Templates with Functional Constraints Open
The popular isolation level Multiversion Read Committed (RC) trades some of the strong guarantees of serializability for increased transaction throughput. Sometimes, transaction workloads can be safely executed under RC obtaining serializa…
View article: Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex Open
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by disti…
View article: Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings
Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings Open
To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single neuron and single spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons…
View article: Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex
Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex Open
Local field potential (LFP) recordings reflect the dynamics of the current source density (CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and sources are ill-understood. We investigated these in mo…