Viswanathan Mohan
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View article: Dairy intake and risk of type 2 diabetes and metabolic syndrome: A narrative review
Dairy intake and risk of type 2 diabetes and metabolic syndrome: A narrative review Open
Dairy products are important components of human health. While some studies claim that dairy increases the risk of type 2 diabetes (T2D) and metabolic syndrome (MetS), several large studies have shown the beneficial impact of dairy consump…
View article: <i>INSR</i> gene mutation masquerading as type 1 diabetes – A case report
<i>INSR</i> gene mutation masquerading as type 1 diabetes – A case report Open
We report a 16-year-old girl diagnosed with a heterozygous mutation in INSR gene leading to monogenic insulin resistance diabetes. She was treated as type 1 diabetes for 2 years before the final diagnosis. Possibility of other types of dia…
View article: Clinical assessment and acceptance criteria for continuous glucose monitoring (CGM) system performance: A proposed guideline by the IFCC Working Group on CGM
Clinical assessment and acceptance criteria for continuous glucose monitoring (CGM) system performance: A proposed guideline by the IFCC Working Group on CGM Open
Continuous glucose monitoring (CGM) systems are essential tools for modern diabetes care. However, the assessment of their analytical performance has been hindered by a lack of standardization. This poses challenges for the field, as the c…
View article: Does health insurance coverage improve cardiometabolic risk factor levels? Quasi-experimental evidence from India
Does health insurance coverage improve cardiometabolic risk factor levels? Quasi-experimental evidence from India Open
Health insurance coverage was associated with better cardiometabolic risk profiles and health status, largely mediated by increased healthcare utilization. Expanding insurance coverage to include outpatient chronic care services should be …
View article: Efficacy and Safety of Once-Weekly Insulin Icodec in Indian Participants with Diabetes: Results from ONWARDS 1, 4, and 6 Studies
Efficacy and Safety of Once-Weekly Insulin Icodec in Indian Participants with Diabetes: Results from ONWARDS 1, 4, and 6 Studies Open
ONWARDS 1: NCT04460885; ONWARDS 4: NCT04880850; ONWARDS 6: NCT04848480.
View article: Multimorbidity among adult Indians –prevaLence, incidence, risk fActors and economic burdeN: the MILAN cohort study protocol
Multimorbidity among adult Indians –prevaLence, incidence, risk fActors and economic burdeN: the MILAN cohort study protocol Open
Introduction Multimorbidity or multiple long-term conditions (MLTCs) are defined as the coexistence of two or more chronic conditions in an individual. With increased longevity and the rising burden of chronic non-communicable diseases (NC…
View article: Effect of 'FenuflakesTM' on 24-hour glycemic variability in adults with type 2 diabetes: A randomized crossover continuous glucose monitoring study.
Effect of 'FenuflakesTM' on 24-hour glycemic variability in adults with type 2 diabetes: A randomized crossover continuous glucose monitoring study. Open
The results suggest that the inclusion of FenuflakesTM, into regular dietary practices may effectively reduce glucose levels and enhance glycemic control in Asian Indian adults with type 2 diabetes.
View article: Optimizing Type 2 Diabetes Management: The Efficacy and Safety of Gliclazide in Clinical Practice
Optimizing Type 2 Diabetes Management: The Efficacy and Safety of Gliclazide in Clinical Practice Open
Sulfonylureas have been used in type 2 diabetes (T2D) management for over six decades, particularly when the use of metformin alone is insufficient. Despite their efficacy, concerns about hypoglycemia and cardiovascular risks have limited …
View article: Dietary profiles and associated metabolic risk factors in India from the ICMR–INDIAB survey-21
Dietary profiles and associated metabolic risk factors in India from the ICMR–INDIAB survey-21 Open
Rapid dietary transitions in India have been associated with an alarming rise in cardiometabolic diseases. Using data from the national Indian Council of Medical Research-India Diabetes survey (18,090 adults), we examined India's dietary p…
View article: Exome-wide association study in 54,698 south Asians identifies novel type 2 diabetes associations with <i>RNF19A</i>, <i>HNF4A</i>, and dissects role of coding variants in GP2 and <i>CDKAL1</i>
Exome-wide association study in 54,698 south Asians identifies novel type 2 diabetes associations with <i>RNF19A</i>, <i>HNF4A</i>, and dissects role of coding variants in GP2 and <i>CDKAL1</i> Open
Type 2 diabetes (T2D) disproportionately affects individuals of South Asian ancestry, yet the underlying genetic aetiology remains poorly understood and in genetic studies these populations remain underrepresented. We conducted an exome-wi…
View article: MetaEmbed: Scaling Multimodal Retrieval at Test-Time with Flexible Late Interaction
MetaEmbed: Scaling Multimodal Retrieval at Test-Time with Flexible Late Interaction Open
Universal multimodal embedding models have achieved great success in capturing semantic relevance between queries and candidates. However, current methods either condense queries and candidates into a single vector, potentially limiting th…
View article: Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes
Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes Open
Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored.…
View article: REFRAG: Rethinking RAG based Decoding
REFRAG: Rethinking RAG based Decoding Open
Large Language Models (LLMs) have demonstrated remarkable capabilities in leveraging extensive external knowledge to enhance responses in multi-turn and agentic applications, such as retrieval-augmented generation (RAG). However, processin…
View article: Comparison of Pregnancy Outcomes between Treated Early Gestational Diabetes Mellitus (EGDM) and Late Gestational Diabetes Mellitus (LGDM)
Comparison of Pregnancy Outcomes between Treated Early Gestational Diabetes Mellitus (EGDM) and Late Gestational Diabetes Mellitus (LGDM) Open
Introduction: Early gestational diabetes mellitus (EGDM) is a relatively new entity, and there is a lack of clarity regarding treatment. This study was carried out to compare the maternal and neonatal outcomes between treated EGDM and late…
View article: The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial
The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial Open
Background Collaborative care models (CoCM) improve both depression and cardiometabolic outcomes, but the mechanisms driving these effects remain unclear. Objective To determine whether changes in depressive symptoms, positive health behav…
View article: Development and Validation of DIANA (Diabetes Novel Subgroup Assessment tool): A web-based precision medicine tool to determine type 2 diabetes endotype membership and predict individuals at risk of microvascular disease
Development and Validation of DIANA (Diabetes Novel Subgroup Assessment tool): A web-based precision medicine tool to determine type 2 diabetes endotype membership and predict individuals at risk of microvascular disease Open
Background Previous research has identified four distinct endotypes of type 2 diabetes in Asian Indians, which include Severe Insulin Deficient Diabetes (SIDD), Combined Insulin Resistant and Deficient Diabetes (CIRDD), Insulin Resistance …
View article: The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study
The burden of cardiovascular events according to cardiovascular risk profile in adults from high-income, middle-income, and low-income countries (PURE): a cohort study Open
The funding bodies are listed in the appendix (p 29).
View article: Neurosteroid Levels in Pregnancy and Its Implications for Mental Health: A Literature Review
Neurosteroid Levels in Pregnancy and Its Implications for Mental Health: A Literature Review Open
Background Perinatal mood disorders are being increasingly recognised and may have deleterious outcomes for the mother and offspring, underlining the importance of understanding their pathophysiology. Neurosteroids can alter the excitabili…