Thomas M. Kündig
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View article: Dimethyl Fumarate Treatment for Psoriasis in Real-World Clinical Practice: An Analysis from the Swiss Registry
Dimethyl Fumarate Treatment for Psoriasis in Real-World Clinical Practice: An Analysis from the Swiss Registry Open
Introduction: Limited data are available on the effectiveness and safety of dimethyl fumarate (DMF) for the treatment of moderate-to-severe psoriasis in real-world clinical practice. The objectives were to assess the effectiveness and safe…
View article: Anti‐ <scp>IL</scp> ‐5 Vaccination Dampens Allergen‐Specific <scp>IgE</scp> Levels and Modulates <scp>IL</scp> ‐4 and <scp>IL</scp> ‐5 Th2 Cytokines in Skin Allergy of Mice and Horses
Anti‐ <span>IL</span> ‐5 Vaccination Dampens Allergen‐Specific <span>IgE</span> Levels and Modulates <span>IL</span> ‐4 and <span>IL</span> ‐5 Th2 Cytokines in Skin Allergy of Mice and Horses Open
Background Skin allergies are among the most frequent types of allergies, where continuous investigation of the pathological immune mechanisms is required for a better understanding and a more effective treatment of the disease. In this st…
View article: Regulatory T Cell Dysregulation in Vitiligo: A Meta‐Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives
Regulatory T Cell Dysregulation in Vitiligo: A Meta‐Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives Open
Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver of disease onset and progression. Regulatory T (Treg) cells are essential for maintaining im…
View article: p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p
p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p Open
The inflammasome sensor NLRP1 is mainly expressed by epithelial cells including keratinocytes of human skin. Germline gain-of-function mutations in NLRP1 cause inflammatory skin syndromes and predispose patients to the development of cutan…
View article: Inflammatory Cutaneous Reactions with Systemic CD8+ T-Cell Responses upon Photochemical Internalization of Antigens in Mice
Inflammatory Cutaneous Reactions with Systemic CD8+ T-Cell Responses upon Photochemical Internalization of Antigens in Mice Open
Vaccination can prevent infections and modulate immune-related diseases. Although conventional vaccines primarily stimulate CD4+ T cells and antibody production, effective antitumor immunity requires activation of CD8+ T cells. Photochemic…
View article: Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT)
Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) Open
Real-world data on gender differences in quality of life among psoriasis patients before and during treatment are scarce. This study analysed data of 748 adults with moderate-to-severe psoriasis enrolled in the Swiss Dermatology Network of…
View article: Tildrakizumab Treatment for Psoriasis in Real-world Practice: An Analysis from the Swiss Registry (SDNTT)
Tildrakizumab Treatment for Psoriasis in Real-world Practice: An Analysis from the Swiss Registry (SDNTT) Open
Real-world data on the effectiveness and safety of tildrakizumab, an interleukin 23p19 inhibitor, in Switzerland is limited. The objectives of this analysis were to assess the effectiveness and safety of tildrakizumab in patients with mode…
View article: Fast Itch Relief during Dupilumab Predicts Clinical Efficacy in Bullous Pemphigoid: A Retrospective Cohort Study
Fast Itch Relief during Dupilumab Predicts Clinical Efficacy in Bullous Pemphigoid: A Retrospective Cohort Study Open
Introduction: Dupilumab has emerged as a promising treatment option for bullous pemphigoid (BP). Rapid identification of responders could avoid the need for additional immunosuppressive treatments that are associated with increased morbidi…
View article: Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo
Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo Open
Synthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development. Such synthetic mRNA typically contains several hundred bases of no…
View article: Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy
Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy Open
Chemotherapies are standard care for most cancer types. Pyrimidine analogs including 5-fluorouracil, cytosine arabinoside, 5-azacytidine, and gemcitabine are effective drugs that are utilized as part of a number of anticancer regimens. How…
View article: CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity
CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity Open
Inflammasomes comprise a group of protein complexes with fundamental roles in the induction of inflammation. Upon sensing stress factors, their assembly induces the activation and release of the pro-inflammatory cytokines interleukin (IL)-…
View article: How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound‐guided injections
How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound‐guided injections Open
Background Intralymphatic immunotherapy (ILIT) represents a promising novel approach treating allergic diseases. However, no standardized procedures or recommendations have been established or reported, despite the recognized fact that tre…
View article: A murine model of peanut-allergic asthma
A murine model of peanut-allergic asthma Open
Objectives Peanut allergy is an IgE-mediated food allergy that is associated with asthma in certain patients. With increasing prevalence, its great impact on the quality of life, and a lack of treatment options, the need for new therapy op…
View article: Atypical and Typical Presentation of Erythema Nodosum: Clinical Differences in Treatment and Outcome
Atypical and Typical Presentation of Erythema Nodosum: Clinical Differences in Treatment and Outcome Open
Introduction: Erythema nodosum (EN) is the most common form of panniculitis that predominantly affects the shins. While EN in atypical sites has been described by many authors, there are currently only case studies published on this topic.…
View article: Predicting Psoriatic Arthritis in Psoriasis Patients – A Swiss Registry Study
Predicting Psoriatic Arthritis in Psoriasis Patients – A Swiss Registry Study Open
Background Psoriatic arthritis (PsA) is a prevalent comorbidity among patients with psoriasis, heavily contributing to their burden of disease, usually diagnosed several years after the diagnosis of psoriasis. Objectives To investigate the…
View article: <scp>BALB</scp>/c and <scp>C3H</scp> mice are both suitable as peanut allergy models
<span>BALB</span>/c and <span>C3H</span> mice are both suitable as peanut allergy models Open
Peanut allergy is a potentially life-threatening IgE-mediated disease with few therapeutic options available; subcutaneous (s.c.) immunotherapy, for example, showed a too high safety risk in the few trials performed.1 Despite peanut oral i…
View article: Inflammation in acute myocardial infarction: the good, the bad and the ugly
Inflammation in acute myocardial infarction: the good, the bad and the ugly Open
Convergent experimental and clinical evidence have established the pathophysiological importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in treating inflammation in patients suffering acute myocardial…
View article: Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors Open
Purpose: The goal of this study was to investigate the therapeutic potential of a novel immunotherapy strategy resulting in immunity to localized or metastatic human papillomavirus 16–transformed murine tumors.Experimental Design: Animals …
View article: Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors Open
Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
View article: Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors Open
Purpose: The goal of this study was to investigate the therapeutic potential of a novel immunotherapy strategy resulting in immunity to localized or metastatic human papillomavirus 16–transformed murine tumors.Experimental Design: Animals …
View article: Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors Open
Supplementary Data from Lymph Node–Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus–Transformed Tumors
View article: The next generation virus‐like particle platform for the treatment of peanut allergy
The next generation virus‐like particle platform for the treatment of peanut allergy Open
Background Allergy to peanut is one of the leading causes of anaphylactic reactions among food allergic patients. Immunization against peanut allergy with a safe and protective vaccine holds a promise to induce durable protection against a…
View article: Targeting Ara h 2 with human‐derived monoclonal antibodies prevents peanut‐induced anaphylaxis in mice
Targeting Ara h 2 with human‐derived monoclonal antibodies prevents peanut‐induced anaphylaxis in mice Open
Background Peanut allergy is a type‐I hypersensitivity immune reaction mediated by the binding of peanut allergens to IgE‐FcεRI complexes on mast cells and basophils and by their subsequent cellular degranulation. Of all major peanut aller…
View article: Dupilumab for Chronic Prurigo: Case Series on Effectiveness, Safety, and Quality of Life
Dupilumab for Chronic Prurigo: Case Series on Effectiveness, Safety, and Quality of Life Open
Background: Chronic prurigo (CPG) is a pruritic skin disease, characterized by an itch-scratch cycle and scarring. It reduces patients’ quality of life (QoL). Dupilumab is a monoclonal human IgG antibody that inhibits signaling of the inte…
View article: Potential Cost Savings by Switching from Subcutaneous to Intralymphatic Insect Venom Immunotherapy
Potential Cost Savings by Switching from Subcutaneous to Intralymphatic Insect Venom Immunotherapy Open
Introduction: IgE-mediated bee venom allergy can be treated with allergen-specific immunotherapy (AIT). Subcutaneous immunotherapy (SCIT) is time and cost intensive due to the repeated consultations, but the costs are justified by the high…
View article: Supplementary Material for: Dupilumab for chronic prurigo: case series on effectiveness, safety, and quality of life
Supplementary Material for: Dupilumab for chronic prurigo: case series on effectiveness, safety, and quality of life Open
Background Chronic prurigo (CPG) is a pruritic skin disease, characterized by an itch–scratch cycle and scarring. It reduces patients’ quality of life (QoL). Dupilumab is a monoclonal human IgG antibody that inhibits signaling of the inter…