Ricardo Machado Kuster
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View article: Short-Term Intake of Euphorbia tirucalli Latex Modifies Kidney Function in Rats: Possible Role of Oxidative Stress and Inflammatory Response
Short-Term Intake of Euphorbia tirucalli Latex Modifies Kidney Function in Rats: Possible Role of Oxidative Stress and Inflammatory Response Open
Medicinal plants have been traditionally used for generations, often without scientific validation. Euphorbia tirucalli (E. tirucalli), a plant native to Africa, is commonly employed in folk medicine for treating various ailments, includin…
View article: Rapid Bactericidal Activity of Punica granatum L. Peel Extract: A Natural Alternative for Mastitis Prevention in Dairy Cattle
Rapid Bactericidal Activity of Punica granatum L. Peel Extract: A Natural Alternative for Mastitis Prevention in Dairy Cattle Open
The increasing prevalence of bacterial resistance to conventional disinfectants and antibiotics has intensified the search for effective, natural alternatives in the dairy industry. This study evaluates the bactericidal efficacy of Punica …
View article: LC-ESI(±)-LTQ MS<sup>n</sup>-Based Metabolomic Profiling of Coffee: Fragmentation Pathways for Identification of Major Polar Compounds
LC-ESI(±)-LTQ MS<sup>n</sup>-Based Metabolomic Profiling of Coffee: Fragmentation Pathways for Identification of Major Polar Compounds Open
Coffee is characterized by a complex chemical matrix that significantly influences its organoleptic properties and market value. This complexity is driven by factors such as botanical species, geographical origin, cultivation conditions, a…
View article: Chemical Diversity and Bioactive Compound Profiling of <i>Calophyllum brasiliense</i> Cambess. Morphotypes
Chemical Diversity and Bioactive Compound Profiling of <i>Calophyllum brasiliense</i> Cambess. Morphotypes Open
Calophyllum brasiliense Cambess . is a native Brazilian tree rich in bioactive compounds, such as coumarins, xanthones, and chromanones. This study investigated the chemical composition of four morphotypes of the species using Fourier‐tran…
View article: Cannabis sativa L.: UMA REVISÃO CRÍTICA SOBRE CANABINOIDES, LEGISLAÇÃO E MÉTODOS ANALÍTICOS
Cannabis sativa L.: UMA REVISÃO CRÍTICA SOBRE CANABINOIDES, LEGISLAÇÃO E MÉTODOS ANALÍTICOS Open
Cannabis sativa L.: A CRITICAL REVIEW OF CANNABINOIDS, LEGISLATION, AND ANALYTICAL METHODS. Forensic chemistry plays a crucial role in criminal investigations, utilizing techniques to analyze evidence such as gunshot residues, explosives, …
View article: Phytochemical profiling, antioxidant, and phytotoxic potentials of Erythrina speciosa Andrews leaves
Phytochemical profiling, antioxidant, and phytotoxic potentials of Erythrina speciosa Andrews leaves Open
In order to enhance the chemical and biological understanding of the genus Erythrina, this study evaluated the chemical composition, phytotoxicity, and antioxidant potential of the hexane (Hex), dichloromethane (DCM), and ethyl acetate (Et…
View article: Pharmacological potential of <i>Euphorbia tirucalli</i> L. latex in gastric adenocarcinoma: from an ethnopharmacological perspective into new products
Pharmacological potential of <i>Euphorbia tirucalli</i> L. latex in gastric adenocarcinoma: from an ethnopharmacological perspective into new products Open
Products derived from the latex of Euphorbia tirucalli were obtained through hydrolysis and column chromatography, resulting in products rich in triterpenes, ingenol 3-esters (I3E), and other derivatives from hydrolysed latex. These produc…
View article: Anthropogenic organic matter influence on epicuticular Tillandsia stricta Sol. ex Sims and Tillandsia usneoides (L.) L. (Bromeliaceae) wax leaf from Rio de Janeiro sandbank
Anthropogenic organic matter influence on epicuticular Tillandsia stricta Sol. ex Sims and Tillandsia usneoides (L.) L. (Bromeliaceae) wax leaf from Rio de Janeiro sandbank Open
Epicuticular wax from the leaves of Tillandsia stricta Sol. Sims and Tillandsia usneoides (L.) from Grumari, Marica and Jurubatiba, Rio de Janeiro sandbanks was extracted into chloroform and n-hexane for analyses. The extracts were subject…
View article: SUSTAINABILITY AND ENVIRONMENTAL ETHICS (FROM THE ENVIRONMENTAL PRIMER TO THE INTERCULTURAL GARDEN)
SUSTAINABILITY AND ENVIRONMENTAL ETHICS (FROM THE ENVIRONMENTAL PRIMER TO THE INTERCULTURAL GARDEN) Open
This article represents the historical record of the stages of the third management of the intercultural didactic garden (medicinal and sensory) in a courtyard used by the Homeopathy Service, located in the 7th Infirmary of the Hospital Ge…
View article: Medicinal intercultural plant garden: homeopathy and phyto-nutritional care
Medicinal intercultural plant garden: homeopathy and phyto-nutritional care Open
The present article describes historic evolution conception process of an intercultural medicinal plant garden as a tool to construct social ecoperception about environmental health and cultural diversity, to improve environmental ethics. …
View article: In Vitro and In Silico Evaluation of Red Algae Laurencia obtusa Anticancer Activity
In Vitro and In Silico Evaluation of Red Algae Laurencia obtusa Anticancer Activity Open
Studies estimate that nearly 2 million new cases of gastric cancer will occur worldwide during the next two decades, which will increase mortality associated with cancer and the demand for new treatments. Marine algae of the Laurencia genu…
View article: Avocado (Persea americana Mill.) seeds compounds affect Helicobacter pylori infection and gastric adenocarcinoma cells growth
Avocado (Persea americana Mill.) seeds compounds affect Helicobacter pylori infection and gastric adenocarcinoma cells growth Open
This study evaluated the effect of hydroalcoholic extract from avocado (Persea americana Mill.) seeds (SCE), and its fractions, ethyl acetate (SEAP) and hexane (SHP), against Helicobacter pylori infection, its pathological process, and ade…
View article: High dilutions of euphorbia tirucalli L. (aveloz) modify the viability and glycolytic metabolism of cell lines
High dilutions of euphorbia tirucalli L. (aveloz) modify the viability and glycolytic metabolism of cell lines Open
The latex of Euphorbia tirucalli L. (Aveloz) is popularly used to treat cancers from diverse sources such as: breast, prostate, lung and kidney. Furthermore, high dilutions of this latex (latex-HDs) have been successfully used in the treat…
View article: Chronic toxicological effects of ultradiluted solutions of Aveloz (Euphorbia tirucalli Lineu) on healthy mice: a preliminary study
Chronic toxicological effects of ultradiluted solutions of Aveloz (Euphorbia tirucalli Lineu) on healthy mice: a preliminary study Open
The latex extracted from Euphorbia tirucalli, a plant popularly known as Aveloz, is used in complementary medicine to induce tumor regression. However, as this latex has toxic effects when administered orally in ponderal doses, the present…
View article: Physical chemical and citotoxic evaluation of highly diluted solutions of Euphorbia tirucalli L. prepared through the fifty milesimal homeopathic method
Physical chemical and citotoxic evaluation of highly diluted solutions of Euphorbia tirucalli L. prepared through the fifty milesimal homeopathic method Open
Background: although Hahnemann described the fifty-milesimal (LM) method in the 6th edition of the Organon of the Medical Art, very little research has been carried out on the physical chemical properties of these homeopathic preparations.…
View article: In vitro antimicrobial activity of Alpinia zerumbet and A. purpurata nonpolar fraction of leaf extract
In vitro antimicrobial activity of Alpinia zerumbet and A. purpurata nonpolar fraction of leaf extract Open
This study aimed to evaluate the in vitro antimicrobial activity of fractions of leaf hydroalcoholic crude extracts: hexane, dichloromethane, ethyl acetate and butanolic of Alpinia zerumbet and A. purpurata by the agar drop diffusion metho…
View article: Virucidal and Antiviral Activity of Extract of Punica Granatum Cultivated in Brazil
Virucidal and Antiviral Activity of Extract of Punica Granatum Cultivated in Brazil Open
Background: The arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Recently, MAYV has attracted …
View article: Chemical Study and Phytotoxic Activity of Fractions from Agroindustrial Residue Vinasse against the Weed Ipomoea purpurea
Chemical Study and Phytotoxic Activity of Fractions from Agroindustrial Residue Vinasse against the Weed Ipomoea purpurea Open
The vinasse residue produced on a large scale in Brazil and in the world by the sugarcane industry is considered highly polluting.The use of this industrial waste solves problems related to environmental pollution.After the fractionation p…
View article: Sugarcane waste products as source of phytotoxic compounds for agriculture
Sugarcane waste products as source of phytotoxic compounds for agriculture Open
Purpose This article aims to evaluate the phytotoxic potential of metabolites present in the waste from sugarcane processing industry, such as vinasse, filter cake and bagasse, in order to reuse them as raw materials for the production of …
View article: PHYTOCHEMICAL SCREENING, ANTIOXIDANT, ANTI-CYTOTOXIC AND ANTICANCER EFFECTS OF GALINSOGA PARVIFLORA AND VERNONIA POLYANTHES (ASTERACEAE) EXTRACTS
PHYTOCHEMICAL SCREENING, ANTIOXIDANT, ANTI-CYTOTOXIC AND ANTICANCER EFFECTS OF GALINSOGA PARVIFLORA AND VERNONIA POLYANTHES (ASTERACEAE) EXTRACTS Open
The study was designed to investigate the chemical composition and the biological effects of G. parviflora and V. polyanthes ethanolic extracts in vitro. Total content of phenols, flavonoids and tannins was quantified by spectrophotometry;…
View article: Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells Open
More than 94% of colorectal cancer cases have mutations in one or more Wnt/β-catenin signaling pathway components. Inactivating mutations in APC or activating mutations in β-catenin ( CTNNB1 ) lead to signaling overactivation and subsequen…
View article: The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation
The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation Open
The deregulation of the Wnt/β-catenin signaling pathway is a central event in colorectal cancer progression, thus a promising target for drug development. Many natural compounds, such as flavonoids, have been described as Wnt/β-catenin inh…
View article: Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves Open
Many of Euphorbiaceae species are recognized as traditional medicinal plants and the oils and latex of many species have also economic importance. In fact, Euphorbia heterophylla L., belonging to this family and popularly known in Brazil a…
View article: Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC-ESI-TWIM-MS: a Comparison with GC-MS and GC × GC-QMS
Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC-ESI-TWIM-MS: a Comparison with GC-MS and GC × GC-QMS Open
The Cannabis sativa L. plant has a complex chemical composition, containing various chemical compounds such as terpenes, sugars, hydrocarbons, steroids, flavonoids, and amino acids. Few works have attempted to identify the constitutional i…
View article: Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L.
Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L. Open
Helicobacter pylori is a bacterium that reaches half of the world population and it’s recognized as the main cause of chronic gastritis and peptic ulcer. In this study, we evaluated the anti-H. pylori, antioxidant and immunomodulatory acti…
View article: Use of the Comprehensive Two-Dimensional Gas Chromatography (GC×GC-qMS) to Characterize The Classes of Saturated Compounds in Brazilian crude Oils
Use of the Comprehensive Two-Dimensional Gas Chromatography (GC×GC-qMS) to Characterize The Classes of Saturated Compounds in Brazilian crude Oils Open
Uso da Cromatografia Gasosa Bidimensional Abrangente (GC×GC-qMS) para Caracterizar as Classes de Compostos Saturados em Petróleos BrasileirosResumo: A produção de petróleo brasileiro na camada do pré-sal consiste em óleos com alto teor de …
View article: Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC‑ESI‑TWIM-MS: a Comparison with GC‑MS and GC × GC-QMS
Analysis of Isomeric Cannabinoid Standards and Cannabis Products by UPLC‑ESI‑TWIM-MS: a Comparison with GC‑MS and GC × GC-QMS Open
The Cannabis sativa L. plant has a complex chemical composition, containing various chemical compounds such as terpenes, sugars, hydrocarbons, steroids, flavonoids, and amino acids. Few works have attempted to identify the constitutional i…
View article: Seasonal effect on Euphorbia tirucalli L. cytotoxicity
Seasonal effect on Euphorbia tirucalli L. cytotoxicity Open
Many studies have reported on the use of Euphorbia species against cancer. Tinctures of Euphorbia tirucalli L., popularly known as aveloz, have been widely used in Brazilian traditional medicine to treat cancer. However, the influence of s…