Mohamed L. Salem
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View article: From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases
From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases Open
Allergic diseases are a significant global health concern. These disorders result from abnormal immune responses to environmental allergens, influenced by genetic, environmental, and epigenetic factors. Among these, histone acetylation has…
View article: Evaluation of NFKB1 and MyD88 expression levels in a sample of non-Hodgkin lymphoma patients before and during chemotherapy
Evaluation of NFKB1 and MyD88 expression levels in a sample of non-Hodgkin lymphoma patients before and during chemotherapy Open
Triggering of Toll-like receptors (TLRs), expressed mainly on innate immune cells, by their specific ligands (TLRLs) induces NF-κB and MyD88, resulting in stimulation of immune responses. In the tumor microenvironment, however, certain TLR…
View article: Impact of cytoreductive surgery with and without chemoradiation on the outcome of induced oral squamous cell carcinoma: an experimental study
Impact of cytoreductive surgery with and without chemoradiation on the outcome of induced oral squamous cell carcinoma: an experimental study Open
Objectives The aim of this study is to evaluate the effect of cytoreductive surgery with and without chemoradiation on tumor size, survival rate and systemic status in hamsters with chemically induced oral squamous cell carcinoma (OSCC). D…
View article: Colchicine Enhances the Apoptotic, Anti-tumor Efficacy, Survival of Doxorubicin and Lowers Associated Toxicity in an Ehrlich Ascites Cancer Mouse Model
Colchicine Enhances the Apoptotic, Anti-tumor Efficacy, Survival of Doxorubicin and Lowers Associated Toxicity in an Ehrlich Ascites Cancer Mouse Model Open
Doxorubicin (DOX) is an effective chemotherapeutic drug, but induces serious adverse effects. The anti-inflammatory drug colchicine (COL) was found to inhibit inflammasome activity involved in DOX side effects. The purpose of this research…
View article: Characterization and antitumor activity of polysaccharides from different fungal taxa in the Gharbiya governorate, Egypt.
Characterization and antitumor activity of polysaccharides from different fungal taxa in the Gharbiya governorate, Egypt. Open
Introduction: Cancer is the second worldwide cause of death.Polysaccharides may act as new safe alternative remedies for cancer treatment.Aim: The present work aimed to survey the ability of different fungi from local habitat to produce po…
View article: Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells
Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells Open
Effector CD8+ T cells conditioned with IL12 during activation mediate enhanced antitumor efficacy after adoptive transfer into lymphodepleted hosts; this is due in part to improved IL7 responsiveness. Therefore, we hypothesized that increa…
View article: Supplemental Figures from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells
Supplemental Figures from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells Open
This file contains the following figures: Supplemental Figure 1. The return of host lymphocytes is affected by the type of donor CD8+ T cells. Supplemental Figure 2. Return of myeloid cells after CTX leads to more rapid host cell reconstit…
View article: Supplemental Figures from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells
Supplemental Figures from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells Open
This file contains the following figures: Supplemental Figure 1. The return of host lymphocytes is affected by the type of donor CD8+ T cells. Supplemental Figure 2. Return of myeloid cells after CTX leads to more rapid host cell reconstit…
View article: Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells
Data from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells Open
Effector CD8+ T cells conditioned with IL12 during activation mediate enhanced antitumor efficacy after adoptive transfer into lymphodepleted hosts; this is due in part to improved IL7 responsiveness. Therefore, we hypothesized that increa…
View article: Synthesis and Study of Anticancer and Antioxidant Activities of 2-oxoquinoline Hydrazide Derivatives
Synthesis and Study of Anticancer and Antioxidant Activities of 2-oxoquinoline Hydrazide Derivatives Open
In this work, hydrazone, thiosemicarbazide, diamide, and dipeptide derivatives were prepared from the glycine and β-alanine hydrazide of 4-hydroxy-2-oxoquinoline. The desired derivative resulted from substitution, hydrazinolysis, condensat…
View article: The Helpful Effect of Vitamin D and Coconut Oil in Modulating the Histological Disorders of the Splenic Tissue in Hyperglycemic Mice
The Helpful Effect of Vitamin D and Coconut Oil in Modulating the Histological Disorders of the Splenic Tissue in Hyperglycemic Mice Open
The present study aims to study the effect of vitamin D (Vit D) or / and coconut oil (Coc) on the splenic histological changes of diabetic adult mice induced by STZ. The mice were divided into 7 groups, and the experimental duration was 4 …
View article: Circulating tumor cells in ovarian cancer patients as a cellular marker for early detection of ovarian cancer in asymptomatic patients
Circulating tumor cells in ovarian cancer patients as a cellular marker for early detection of ovarian cancer in asymptomatic patients Open
Purpose Ovarian cancer (OC) is the leading cause of death among gynecologic cancers worldwide. The aim of this study was to identify and enumerate circulating tumor cells (CTCs) in OC patients and correlate their numbers with the clinical …
View article: Mycosis fungoides: Review and updates
Mycosis fungoides: Review and updates Open
Mycosis fungoides is the most common type of cutaneous T cell lymphoma. The early diagnosis of MF is still an area of debate and challenging issue due to its resemblance to chronic inflammatory dermatoses. Therefore, MF diagnosis is usuall…
View article: Achillea santolina and Raphanus sativus extracts downregulated the expression of the developmental genes NOTCH1, SIX1 and WNT1 in colon and breast cancer cell lines.
Achillea santolina and Raphanus sativus extracts downregulated the expression of the developmental genes NOTCH1, SIX1 and WNT1 in colon and breast cancer cell lines. Open
Background : Although anticancer treatment with chemotherapy is an effective approach, the development of cancer stem cells is regulated by several genes, including NOTCH1 , SIX1 , and WNT1 . Sowe have recently found that treatment of Caco…
View article: Beneficial Modulatory Effects of Treatment With Bone Marrow Lysate on Hematopoietic Stem Cells and Myeloid Cells in Tumor-Bearing Mice
Beneficial Modulatory Effects of Treatment With Bone Marrow Lysate on Hematopoietic Stem Cells and Myeloid Cells in Tumor-Bearing Mice Open
Introduction: Leukopenia is one of the major side effects of myelosuppressive chemotherapy such as cyclophosphamide (CTX). We and others have used CTX either alone or in combination with G-CSF for the mobilization of hematopoietic stem cel…
View article: Effect of IL6 -174 G/C Gene Polymorphism on Response to Interleukin-6 Blocking Therapy in Systemic Juvenile Idiopathic Arthritis
Effect of IL6 -174 G/C Gene Polymorphism on Response to Interleukin-6 Blocking Therapy in Systemic Juvenile Idiopathic Arthritis Open
Objective: The main objective of this study was to evaluate the association of IL6-174 G/C gene polymorphisms and the response to tocilizumab (TCZ) in patients with systemic juvenile idiopathic arthritis (s-JIA).
Methods: Sixty patients w…
View article: In vitro conditioning of antigen-reactive CD8+ T cells with toll-like receptor agonists enhances their expansion in vivo in an adoptive transfer mouse model
In vitro conditioning of antigen-reactive CD8+ T cells with toll-like receptor agonists enhances their expansion in vivo in an adoptive transfer mouse model Open
Background: Anti-cancer adoptive T cell therapy has shown significant anti-tumor responses in cancer patients. This therapy is based on in vitro activation of autologous T cells harvested from a cancer patient and infusing them back throug…
View article: Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin
Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin Open
Background:Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mic…
View article: Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients
Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients Open
Background:The biology of breast cancer was shown to vary in different ethnic populations.Fibronectin (FN) and laminin (LN) are adhesive glycoproteins present in the extracellular matrix (ECM) and have been shown to associate with prognosi…
View article: Effect of IL6 -174 G/C Gene Polymorphism on Response to Interleukin-6 Blocking Therapy in Systemic Juvenile Idiopathic Arthritis.
Effect of IL6 -174 G/C Gene Polymorphism on Response to Interleukin-6 Blocking Therapy in Systemic Juvenile Idiopathic Arthritis. Open
Objective: The main objective of this study is to analyze and evaluate the association of IL6-174 G/C gene polymorphisms with response to interleukin-6 blockade in Egyptian patients with systemic juvenile idiopathic arthritis, and to asses…
View article: Beneficial prophylactic effects of poly(I:C) and zymosan against Schistosoma mansoni infection: MSc Thesis Abstract
Beneficial prophylactic effects of poly(I:C) and zymosan against Schistosoma mansoni infection: MSc Thesis Abstract Open
Background:The use of vaccination in the control of schistosomiasis at a population level induced low cure rates and also resistance to drugs has been recently recorded in Egyptian patients.For these reasons, a search for new drugs with ad…
View article: Impact of the treatment with praziquantel and cisplatin on some biochemical parameters after Schistosoma mansoni infection and Ehrlich ascetic carcinoma in mouse model: Thesis Abstract
Impact of the treatment with praziquantel and cisplatin on some biochemical parameters after Schistosoma mansoni infection and Ehrlich ascetic carcinoma in mouse model: Thesis Abstract Open
Background: Infections with Schistosoma mansoni considers a potential factor for developing cancers in different parts of the human body.Aim: This study evaluates the efficacy of cisplatin and its possible role as a complementary medicine …
View article: Assessment of the relationship between psychological locus of control and immune status in breast cancer patients: Thesis Abstract
Assessment of the relationship between psychological locus of control and immune status in breast cancer patients: Thesis Abstract Open
Background: Several recent studies confirm the immune disturbances in cancer patients in comparison with the healthy individual.Other studies confirmed the effective role of psychological status on the immune system.In breast cancer patien…
View article: Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract
Comparative histological and immunological studies on young and aged inbred and outbred mice: PhD Thesis Abstract Open
Background: Using of experimental animal as models to mimic human pathological conditions has facilitated understanding the mechanisms of different processes involved in these diseases.Among the experimental animals, mice are the mostly wi…