Giuseppe Lippi
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View article: Can Free AI Tools Replace Statistical Software in Data Analysis?
Can Free AI Tools Replace Statistical Software in Data Analysis? Open
Artificial intelligence (AI) has become increasingly integrated into scientific publishing, performing a vast array of tasks for enhancing research efficiency, analysis, and dissemination [...]
View article: Beautiful weights, misinterpreted effects: The use and misuse of overlap weighting in major medical journals, 2020-2025
Beautiful weights, misinterpreted effects: The use and misuse of overlap weighting in major medical journals, 2020-2025 Open
This commentary examined how major medical journals (2020-2025) report studies using overlap weighting, a method that focuses on patients who could receive either treatment. Most studies used the method correctly but did not clearly state …
View article: The impact of circadian rhythms on biomolecular set points: implications for disease diagnosis and monitoring
The impact of circadian rhythms on biomolecular set points: implications for disease diagnosis and monitoring Open
Laboratory data must be both analytically accurate and interpreted with clinically accuracy for safeguarding patient safety. However, variations – both analytical and biological – are inherent in all measurements obtained from patient samp…
View article: Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol Open
Essential oil-derived compounds such as eugenol, thymol, cinnamaldehyde, and carvacrol exhibit potent antimicrobial and anti-inflammatory properties, making them promising candidates for therapeutic and industrial applications. This review…
View article: Perspectives on emerging challenges and training needs for the Laboratory Medicine specialist of the future
Perspectives on emerging challenges and training needs for the Laboratory Medicine specialist of the future Open
Laboratory Medicine has undergone a radical transformation since its early 20th-century origins, evolving from rudimentary hospital laboratories into a technologically advanced discipline. Laboratory Medicine specialists now play multiface…
View article: Biomarkers of Sepsis Severity: A Comparative Evaluation of Immunological and Biochemical Parameters
Biomarkers of Sepsis Severity: A Comparative Evaluation of Immunological and Biochemical Parameters Open
Background: Sepsis is a significant health concern characterized by high mortality rates, further complicated by diagnostic challenges and the absence of reliable prognostic biomarkers. Objective: To investigate the clinical value of speci…
View article: Rising stroke mortality in the wake of COVID-19: unraveling the long-term impact of the pandemic on cerebrovascular health
Rising stroke mortality in the wake of COVID-19: unraveling the long-term impact of the pandemic on cerebrovascular health Open
Evidence indicates that the risk of stroke has increased during the ongoing coronavirus disease 2019 (COVID-19) pandemic. This study aims to analyze recent trends in stroke mortality in the United States from 2018 to 2024. Data from the US…
View article: Evaluating the Accuracy of AI-Generated Text Detection in Scientific Writing
Evaluating the Accuracy of AI-Generated Text Detection in Scientific Writing Open
Background: The rapid advancement of artificial intelligence (AI) tools, especially in natural language processing, is transforming scientific writing by improving efficiency, consistency and accessibility, especially for non-native Englis…
View article: Mortality trends for bacterial septicaemia in the United States (1999–2024): Age, sex disparities and the impact of the COVID-19 pandemic
Mortality trends for bacterial septicaemia in the United States (1999–2024): Age, sex disparities and the impact of the COVID-19 pandemic Open
Although cumulative mortality for bacterial septicaemia remained stable in the long term, rising deaths in middle-aged adults and pandemic-related increases highlight the need for reinforced prevention, timely diagnosis and accurate manage…
View article: Improving diagnosis in health care: laboratory medicine
Improving diagnosis in health care: laboratory medicine Open
Accurate and timely diagnosis remains one of the most complex and challenging processes in medicine. Diagnostic errors pose a significant burden on patients and healthcare systems, with laboratory-related errors playing a substantial role,…
View article: The increasing association of pulmonary embolism with cancer deaths: A seven-year, US-based, nationwide analysis
The increasing association of pulmonary embolism with cancer deaths: A seven-year, US-based, nationwide analysis Open
Our findings suggest that enhancing PE prevention remains an important clinical goal, but support also the need for further research to clarify whether this association reflects a causal relationship.
View article: Correction: Nocini et al. Improving Nasal Protection for Preventing SARS-CoV-2 Infection. Biomedicines 2022, 10, 2966
Correction: Nocini et al. Improving Nasal Protection for Preventing SARS-CoV-2 Infection. Biomedicines 2022, 10, 2966 Open
In the original publication [...]
View article: A Comparative Evaluation of the Chemiluminescence Immunoassay and ELISA for the Detection of Islet Autoantibodies in Type 1 Diabetes
A Comparative Evaluation of the Chemiluminescence Immunoassay and ELISA for the Detection of Islet Autoantibodies in Type 1 Diabetes Open
Background: The early detection of type 1 diabetes (T1D) through screening for major islet autoantibodies is receiving increasing attention as a public health strategy, exemplified by the recent implementation of a pilot pediatric screenin…
View article: Analyzing COVID-19 Deaths by Weekday: A Four-Year Statistical Review (2020–2023)
Analyzing COVID-19 Deaths by Weekday: A Four-Year Statistical Review (2020–2023) Open
Background: Earlier studies suggested that coronavirus disease 2019 (COVID-19) mortality may vary by the day of the week, possibly due to healthcare system workflows or reporting delays. This study aimed to assess whether such day-of-week …
View article: Development of translational read-through-inducing drugs as novel therapeutic options for patients with Fanconi anemia
Development of translational read-through-inducing drugs as novel therapeutic options for patients with Fanconi anemia Open
Fanconi anemia (FA) is caused by mutations affecting FANC genes involved in DNA repair, with nearly 20% of FA patients harboring nonsense mutations. Ataluren (PTC124) is a translational read-through-inducing drug (TRID) already approved in…
View article: COVID-19 Mortality Trends over the First Five Years of the Pandemic in the US
COVID-19 Mortality Trends over the First Five Years of the Pandemic in the US Open
Background/Objectives: This retrospective observational study investigated coronavirus disease 2019 (COVID-19)-related mortality trends in the US throughout the pandemic. Methods: We performed a retrospective, descriptive analysis between …
View article: Comparative Evaluation of Chemiluminescence Immunoassay and ELISA for the Detection of Islet Autoantibodies in Type 1 Diabetes
Comparative Evaluation of Chemiluminescence Immunoassay and ELISA for the Detection of Islet Autoantibodies in Type 1 Diabetes Open
Background: Early detection of type 1 diabetes (T1D) through major islet antibodies screening is gaining momentum as public health strategy, with Italy recently implementing a pilot pediatric screening program. The transition from research…
View article: Unveiling the hidden clinical and economic impact of preanalytical errors
Unveiling the hidden clinical and economic impact of preanalytical errors Open
The preanalytical phase is the basis upon which the accuracy and reliability of laboratory testing mostly depend. Despite many recent advancements in laboratory medicine, preanalytical errors remain the most common source of diagnostic ina…
View article: Security and Privacy Challenges and Solutions in Autonomous Driving Systems: A Comprehensive Review
Security and Privacy Challenges and Solutions in Autonomous Driving Systems: A Comprehensive Review Open
The rapid advancement of autonomous driving technology has transformed modern transportation, offering enhanced safety, efficiency, and convenience. However, as these vehicles become increasingly connected and reliant on complex software a…
View article: Emergency department visits in Italy: 2017-2023 trends, decline and recovery
Emergency department visits in Italy: 2017-2023 trends, decline and recovery Open
This study analyzes the trend of Emergency Department (ED) visits in Italy between 2017-2023 using data of Italian National Institute for Statistics (ISTAT). We found a fluctuating trend, with ED visits peaking in 2019, followed by a sharp…
View article: Oral Anticoagulation Therapy: An Update on Usage and Costs in the Endemic COVID-19 Era
Oral Anticoagulation Therapy: An Update on Usage and Costs in the Endemic COVID-19 Era Open
Background/Objectives: Oral anticoagulant (OA) therapy (OAT) may be prescribed to patients for a variety of reasons, with several agent classes currently available as well as emerging. The classical oral anticoagulants are represented by v…