Sidnei Moura
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Exploring the antinociceptive activity and toxicological profile of Zn(Valp)<sub>2</sub>Bipy: a promising molecule in pain research Open
Zn(Valp)2Bipy demonstrated significant antinociceptive activity through central and peripheral mechanisms without detectable toxicity. This study provides the first evidence of analgesic potential for this complex, highlighting it as a pro…
Synthesis and Chemical Characterization of Chloroquine, Hydroxychloroquine, Zinc, and Cinnamic Acid Organocomplexes: Potential Drug Candidates for SARS‐CoV‐2 Treatment and Microbial Control Open
COVID‐19, caused by the SARS‐CoV‐2 virus, continues to be a significant concern due to its ongoing circulation and the risk of bacterial co‐infections, particularly with Staphylococcus aureus and Escherichia coli . Drug repositioning strat…
Scaffold Hopping Strategy toward New 4-Aminoquinazolines Active Against Extracellular and Intracellular <i>Mycobacterium tuberculosis</i> Open
A series of 4-aminoquinazolines was designed through a scaffold hopping approach inspired by pharmacophoric features of known antimycobacterial agents. The compounds were synthesized via a one-pot silylation-amination reaction under solven…
Grape By‐Products for Smart Packaging Films: Antioxidant, pH‐Sensitive, UV‐Blocking and Antimicrobial Properties for Food Preservation Open
Grape by‐products, including seeds, skins and stalks, have garnered attention for the development of active and intelligent films due to their phenolic‐rich composition. These by‐products contain compounds such as carotenoids, flavonoids, …
Marine and terrestrial biostimulant elicitors of tolerance to cold stress Open
The increasing frequency of adverse environmental events, driven by ongoing climate change, has intensified the search for new technological alternatives in crop production and plant protection. Thermal stress can limit plant adaptation an…
Brazilian honey: Metabolomic analysis and characterization by 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and chemometrics Open
Honey is a complex matrix that contains a wide range of compounds. This rich composition is influenced by diverse environmental factors, including geographic and botanical origin. Honey has been among the most commonly tampered foods world…
Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review Open
Quinolines obtained from native trees of South and Central America, of the genus Cinchona , have been used since the 17th century for the treatment of malaria. However, it was only in 1820 that quinine had its structure elucidated, and sub…
A Comprehensive Multi-Method Approach to Investigating Simvastatin Forced Degradation: Integrating in silico Evaluation with HRMS, NMR, and UV-HPLC Open
Simvastatin, developed in the 1980s, is a widely prescribed medication used to treat hyperlipidemias and lower the risk of cardiovascular diseases, earning its status as a blockbuster drug globally. However, simvastatin has points of insta…
Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and <i>In Vivo</i> Exposure Open
This work presents a comprehensive investigation into the design, synthesis, and evaluation of a novel series of 4-alkoxyquinolines as potential antimycobacterial agents. The design approach, which combined molecular simplification and cha…
View article: Shotgun proteomic analysis of the caterpillar Lonomia obliqua (Lepitoptera, Saturniidae) hemolymph and effects in rat hippocampal neurons culture
Shotgun proteomic analysis of the caterpillar Lonomia obliqua (Lepitoptera, Saturniidae) hemolymph and effects in rat hippocampal neurons culture Open
Study of substances with potentially neuroprotective has been one of the research focus on drugs development. Toxic proteins of Lonomia obliqua caterpillars, which have caused several accidents in southern Brazil, were identified in the he…
View article: Crystal structure of dihydroneopterin aldolase from <i>Mycobacterium tuberculosis</i> associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, <i>in vitro</i> toxicity and antitubercular activity
Crystal structure of dihydroneopterin aldolase from <i>Mycobacterium tuberculosis</i> associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, <i>in vitro</i> toxicity and antitubercular activity Open
The crystallographic structure of the FolB enzyme from Mycobacterium tuberculosis (MtFolB), complexed with its inhibitor 8-mercaptoguanine (8-MG), was elucidated at a resolution of 1.95 Å. A novel series of S8-functionalized 8-MG derivativ…
View article: Neurotoxicological effects of agrochemicals and their probable degradation by-products in Drosophila melanogaster
Neurotoxicological effects of agrochemicals and their probable degradation by-products in Drosophila melanogaster Open
Photodegradation is a promising technique for remediating contaminated environmental matrices, demonstrating significant yield of transforming organic contaminants into carbon dioxide, water, and inorganic anions through degradation reacti…
Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance Open
In the present study, an insulin-resistant cell model (human hepatocellular carcinoma cell line: HepG2) was chosen to investigate the efficacy of two compound classes and their common molecular motif for glycemic control and insulin sensit…
Chemical characterization of Callingcard Vine (Entada polystachya (L.) DC. var. polystachya) aqueous seed extract and evaluation of its cytotoxic, genotoxic and mutagenic properties Open
Callingcard Vine (Entada polystachya (L.) DC. var. polystachya - Fabaceae) is a common plant in coastal thickets from western Mexico through Central America to Colombia and Brazil, especially in Amazon biome. It has been popularly used as …
Hydroxyhydroquinone and Quassinoids as Promising Compounds with Hypoglycemic Activity through Redox Balance Open
Reactive oxygen species (ROS) are essential signaling molecules involved in almost all metabolic processes. In the present study, a HepG2 insulin resistant cell model (HepG2/IRM) was chosen to investigate the efficacy of hydroxyhydroquinon…
View article: CCDC 2152006: Experimental Crystal Structure Determination
CCDC 2152006: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Shotgun proteomic analysis of the caterpillar<i>Lonomia obliqua</i>(Lepitoptera, Saturniidae) hemolymph and effects in rat hippocampal neurons culture
Shotgun proteomic analysis of the caterpillar<i>Lonomia obliqua</i>(Lepitoptera, Saturniidae) hemolymph and effects in rat hippocampal neurons culture Open
Study of substances with potentially neuroprotective has been one of the research focus on drugs development. Toxic proteins of Lonomia obliqua caterpillars, which have caused several accidents in southern Brazil, were identified in the he…
View article: Four Brazilian Potential Species Almost Unexplored of Connaraceae Family Used Popularly for Diabetes: Chemical Composition and in vitro Activity
Four Brazilian Potential Species Almost Unexplored of Connaraceae Family Used Popularly for Diabetes: Chemical Composition and in vitro Activity Open
Connaraceae is a plant family usually used in traditional medicine. Recently, we have reported the chemical composition and biological activity of 39 species around the world. This work highlights the application of these species to diabet…
PESTICIDES IN PROCESSED FOOD - MULTIRESIDUE PESTICIDES IN NATURAL GRAPE JUICES BY HIGHRESOLUTION MASS SPECTROMETRY Open
Grapes are among the most widely cultivated fruits in the world, with the majority of Brazilian production focusing on natural grape juice. In this work, a total of 40 samples of 2 types of natural grape juice were analyzed for the presenc…
In vitro effect of two resin based materials for treating initial caries lesion around braces, under cariogenic challenge Open
The resin sealant Pro Seal® had a positive protective effect under white spot environmental area and Icon® infiltrant, although showed some protection, did not statistically differ from controls. Key words:Dental Caries, Orthodontics, Dent…
Characterization of Planktochlorella nurekis Extracts and Virucidal Activity against a Coronavirus Model, the Murine Coronavirus 3 Open
Certain members of the Coronaviridae family have emerged as zoonotic agents and have recently caused severe respiratory diseases in humans and animals, such as SARS, MERS, and, more recently, COVID-19. Antivirals (drugs and antiseptics) ca…
Synthesis of <i>N</i>-phenyl- and <i>N</i>-thiazolyl-1<i>H</i>-indazoles by copper-catalyzed intramolecular <i>N</i>-arylation of <i>ortho</i>-chlorinated arylhydrazones Open
The broad application of 1 H -indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular N -arylation of in situ-generated or isolat…