Mathilde Leboutte
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P0135 Effect of human recombinant IL-33 on fibrosis markers in colonic fibroblasts Open
Background IBD is frequently complicated by intestinal fibrosis and strictures formation, occurring in more than 50% of Crohn’s disease (CD) and 5% of ulcerative colitis. Intestinal fibrosis leads to surgery in CD and strictures frequently…
View article: P0177 Dietary prevention of undernutrition reduces intestinal inflammation in a DSS-induced model of colitis and is associated with anti-inflammatory metabolites-producing bacteria
P0177 Dietary prevention of undernutrition reduces intestinal inflammation in a DSS-induced model of colitis and is associated with anti-inflammatory metabolites-producing bacteria Open
Background Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition1. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality …
Crohn’s disease: Why the ileum? Open
Crohn's disease (CD) is an inflammatory bowel disease characterized by immune-mediated flares affecting any region of the intestine alternating with remission periods. In CD, the ileum is frequently affected and about one third of patients…
View article: Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts
Dietary AhR Ligands Have No Anti-Fibrotic Properties in TGF-β1-Stimulated Human Colonic Fibroblasts Open
Background: Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) patients without specific treatment. Aryl hydrocarbon receptor (AhR) activation is associated with better outcomes in intestinal inflammation. Dev…
Gut Microbiota, Macrophages and Diet: An Intriguing New Triangle in Intestinal Fibrosis Open
Intestinal fibrosis is a common complication in inflammatory bowel disease (IBD) without specific treatment. As macrophages are the key actors in inflammatory responses and the wound healing process, they have been extensively studied in c…
Diet in Intestinal Fibrosis: A Double-Edged Sword Open
The natural history of inflammatory bowel diseases, especially Crohn’s disease, is frequently complicated by intestinal fibrosis. Because of the lack of effective treatments for intestinal fibrosis, there is an urgent need to develop new t…