Patrick M. Lelliott
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View article: Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces
Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces Open
The environmental fragmentation of plastic waste leads to the formation of micro- and nanoplastics (MNPs), which pose serious ecological and human health concerns. Despite increasing interest in their biological effects, many studies rely …
View article: Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis
Single–cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis Open
Cardiac fibrosis is a major cause of cardiac dysfunction. Recently, single-cell genomic approaches have revealed in unprecedented resolution the orchestrated cellular responses driving cardiac fibrosis. Yet, the fibrosis-causing phenotypes…
View article: Single-cell Raman microscopy with machine learning highlights distinct biochemical features of neutrophil extracellular traps and necrosis
Single-cell Raman microscopy with machine learning highlights distinct biochemical features of neutrophil extracellular traps and necrosis Open
The defining biology that distinguishes neutrophil extracellular traps (NETs) from other forms of cell death is unresolved, and techniques which unambiguously identify NETs remain elusive. Raman scattering measurement provides a holistic o…
View article: Cellular Adhesion Is a Controlling Factor in Neutrophil Extracellular Trap Formation Induced by Anti-Neutrophil Cytoplasmic Antibodies
Cellular Adhesion Is a Controlling Factor in Neutrophil Extracellular Trap Formation Induced by Anti-Neutrophil Cytoplasmic Antibodies Open
Anti-neutrophil cytoplasmic Ab (ANCA)–associated vasculitis (AAV) is a life-threatening condition characterized by improper activation of neutrophils and the release of neutrophil extracellular traps (NETs) in small vessels. This study aim…
View article: Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies
Cellular adhesion is a controlling factor in neutrophil extracellular trap formation induced by antineutrophil cytoplasmic antibodies Open
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a life-threatening condition characterized by improper activation of neutrophils and release of neutrophil extracellular traps (NETs) in small vessels. This study a…
View article: ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity
ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity Open
Influenza A virus (IAV) triggers the infected lung to produce IL-1 and recruit neutrophils. Unlike IL-1β, however, little is known about IL-1α in terms of its mechanism of induction, action and physiological relevance to the host immunity …
View article: Rapid Quantification of NETs <i>In Vitro</i> and in Whole Blood Samples by Imaging Flow Cytometry
Rapid Quantification of NETs <i>In Vitro</i> and in Whole Blood Samples by Imaging Flow Cytometry Open
Neutrophil extracellular trap (NET) formation involves the release of DNA outside the cell to neutralize pathogens. Techniques such as live microscopy, flow cytometry, and intravital imaging allow the characterization of NETs, but these ei…
View article: Comparative population genomics reveals key barriers to dispersal in Southern Ocean penguins
Comparative population genomics reveals key barriers to dispersal in Southern Ocean penguins Open
The mechanisms that determine patterns of species dispersal are important factors in the production and maintenance of biodiversity. Understanding these mechanisms helps to forecast the responses of species to environmental change. Here, w…
View article: Erythrocyte β spectrin can be genetically targeted to protect mice from malaria
Erythrocyte β spectrin can be genetically targeted to protect mice from malaria Open
Key Points Mutations in β spectrin cause microcytosis, resulting in increased clearance of erythrocytes and enhanced resistance to malaria in mice. A homozygous CRISPR/Cas9-induced mutation in the binding site between β spectrin and ankyri…
View article: Extracellular histones induce erythrocyte fragility and anemia
Extracellular histones induce erythrocyte fragility and anemia Open
Key Points Histones promote in vitro erythrocyte aggregation, sedimentation, fragility, and spleen retention in a concentration-dependent manner. Histones induce in vivo anemia, an increase in splenic hemoglobin content, as well as thrombo…
View article: Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria
Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria Open
Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand th…
View article: Ankyrin-1 gene exhibits allelic heterogeneity in conferring protection against malaria
Ankyrin-1 gene exhibits allelic heterogeneity in conferring protection against malaria Open
Allelic heterogeneity is a common phenomenon where a gene exhibit different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it allowed us to explore and understand the i…
View article: A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice
A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice Open
Genetic defects in various red blood cell (RBC) cytoskeletal proteins have been long associated with changes in susceptibility towards malaria infection. In particular, while ankyrin (Ank-1) mutations account for approximately 50% of hered…
View article: A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice
A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice Open
Genetic defects in various red blood cell (RBC) cytoskeletal proteins have been long associated with changes in susceptibility towards malaria infection. In particular, while ankyrin (Ank-1) mutations account for approximately 50% of hered…
View article: IFN-γ protects hepatocytes against<i>Plasmodium vivax</i>infection via LAP-like degradation of sporozoites
IFN-γ protects hepatocytes against<i>Plasmodium vivax</i>infection via LAP-like degradation of sporozoites Open
The first few days of exposure to Plasmodium sporozoites following a mosquito bite is a critical stage of malaria infection. From the bite site, sporozoites quickly migrate through the bloodstream and invade hepatocytes. Hepatocyte invasio…