Suzanne Lenhart
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View article: Data-driven modeling of amyloid-β targeted antibodies for Alzheimer’s disease
Data-driven modeling of amyloid-β targeted antibodies for Alzheimer’s disease Open
Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta, which is strongly associated with disease progression and cognitive decline. Despite the approval of monoclonal antibodies targeting Aβ, optimizing treatment st…
Dr. Jekyll and Mr. Hyde: How Different Ecosystem (Dis)Services Perspectives Alter Management Decisions of a Native Invasive Encroachment Open
As a consequence of climate change, the encroachment of the native species Empetrum nigrum (crowberry) is exerting multifaceted effects on the Arctic socio‐ecological system in Norway. The native invader detrimentally affects the quality o…
An agent-based model for household COVID-19 transmission in Gauteng, South Africa Open
Since the discovery of COVID-19 in Wuhan, China in 2019, close to seven million people have died from the infection. At the onset of the pandemic, many countries enacted stringent measures such as school and event closings in a bid to cont…
View article: Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer's Disease
Data-Driven Modeling of Amyloid-beta Targeted Antibodies for Alzheimer's Disease Open
Alzheimer's disease (AD) is driven by the accumulation of amyloid-beta (Abeta) proteins in the brain, leading to memory loss and cognitive decline. While monoclonal antibodies targeting Abetahave been approved, optimizing their use to maxi…
The contribution of community transmission to the burden of hospital-associated pathogens: A systematic scoping review of epidemiological models Open
Healthcare-associated infections (HAI), particularly those involving multi-drug resistant organisms (MDRO), pose a significant public health threat. Understanding the transmission of these pathogens in short-term acute care hospitals (STAC…
Optimal control of treatment in a free boundary problem modeling multilayered tumor growth Open
We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor ti…
View article: The Contribution of Community Transmission to the Burden of Hospital-associated Pathogens: A Systematic Scoping Review of Epidemiological Models
The Contribution of Community Transmission to the Burden of Hospital-associated Pathogens: A Systematic Scoping Review of Epidemiological Models Open
Healthcare-associated infections (HAI), particularly those involving multi-drug resistant organisms (MDRO), pose a significant public health threat. Understanding the transmission of these pathogens in short-term acute care hospitals (STAC…
Modeling county level COVID-19 transmission in the greater St. Louis area: Challenges of uncertainty and identifiability when fitting mechanistic models to time-varying processes Open
We use a compartmental model with a time-varying transmission parameter to describe county level COVID-19 transmission in the greater St. Louis area of Missouri and investigate the challenges in fitting such a model to time-varying process…
Geographic disparities and predictors of COVID-19 vaccination in Missouri: a retrospective ecological study Open
Background Limited information is available on geographic disparities of COVID-19 vaccination in Missouri and yet this information is essential for guiding efforts to improve vaccination coverage. Therefore, the objectives of this study we…
Optimal control of an epidemic model with treatment in the presence of media coverage Open
During large scale outbreaks of infectious diseases, it is imperative that media report about the potential risks. Because media reporting plays a vital role in disseminating crucial information about diseases and its associated risk, unde…
Modeling the population dynamics and movement of Zebra mussels Open
Zebra mussels have caused significant damage in many lakes and rivers. By using a hybrid population model with discrete-time equations and ordinary differential equations, we represent the zebra mussel's life cycle, growth, and population …
Modeling impact of vaccination on COVID-19 dynamics in St. Louis Open
The region of St. Louis, Missouri, has displayed a high level of heterogeneity in COVID-19 cases, hospitalization, and vaccination coverage. We investigate how human mobility, vaccination, and time-varying transmission rates influenced SAR…
View article: Interaction of hemlock woolly adelgid populations with host tree health drives population oscillations
Interaction of hemlock woolly adelgid populations with host tree health drives population oscillations Open
Adelges tsugae Annand, the hemlock woolly adelgid, is an invasive insect pest of Tsuga canadensis (L.) Carriere, eastern hemlock, in the eastern United States. An A. tsugae infestation often results in the death of T. canadensis within yea…
Optimally controlling nutrition and propulsion force in a long distance running race Open
Introduction Runners competing in races are looking to optimize their performance. In this paper, a runner's performance in a race, such as a marathon, is formulated as an optimal control problem where the controls are: the nutrition intak…
Toward an optimal contraception dosing strategy Open
Anovulation refers to a menstrual cycle characterized by the absence of ovulation. Exogenous hormones such as synthetic progesterone and estrogen have been used to attain this state to achieve contraception. However, large doses are associ…
Modeling the impacts of temperature during nesting seasons on Loggerhead (Caretta caretta) Sea Turtle populations in South Florida Open
Loggerhead sea turtles (Caretta caretta) are a threatened sea turtle species that nests on beaches along the northwestern Atlantic Ocean. Loggerhead nesting in Florida accounts for approximately 80% of the loggerhead population in the Atla…
View article: Quantitative Biology at Community Colleges, a Network of Biology and Mathematics Faculty Focused on Improving Numerical and Quantitative Skills of Students
Quantitative Biology at Community Colleges, a Network of Biology and Mathematics Faculty Focused on Improving Numerical and Quantitative Skills of Students Open
Quantitative Biology at Community Colleges (QB@CC) is an NSF-funded, RCN-UBE grant that builds collaborative teams of biology, mathematics, and statistics faculty from community colleges across the United States to generate ready-to-implem…
Leveraging federalism for flexible and robust management of social‐ecological systems Open
Managing social‐ecological systems (SES) requires balancing the need to tailor actions to local heterogeneity and the need to work over large areas to accommodate the extent of SES. This balance is particularly challenging for policy since…
The effect of changing COVID-19 restrictions on the transmission rate in a veterinary clinic Open
With the declaration of the COVID-19 pandemic by the World Health Organization on March 11, 2020, the University of Tennessee College of Veterinary Medicine (UTCVM), like other institutions, restructured their services to reduce the potent…
Optimal control of CPR procedure using hemodynamic circulation model Open
A method for determining a chest pressure profile for cardiopulmonary resuscitation (CPR) includes the steps of representing a hemodynamic circulation model based on a plurality of difference equations for a patient, applying an optimal co…