Marco Vincenzo Lenti
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View article: Autoimmune gastritis: Diagnosis, clinical management and natural history. A position paper by the Autoimmune gastRitis Italian netwOrk Study grOup (ARIOSO)
Autoimmune gastritis: Diagnosis, clinical management and natural history. A position paper by the Autoimmune gastRitis Italian netwOrk Study grOup (ARIOSO) Open
View article: Vitamin B12 in Cancer Patients: Clinical Insights into Deficiency, Excess, Diagnosis, and Management
Vitamin B12 in Cancer Patients: Clinical Insights into Deficiency, Excess, Diagnosis, and Management Open
Vitamin B12 (cobalamin) is a critical micronutrient involved in hematopoiesis and neurological function. Its deficiency, commonly presenting with anemia and neurological symptoms, is particularly relevant in oncology. While anemia affects …
View article: Pediatric autoimmune gastritis: An international, multicentric study
Pediatric autoimmune gastritis: An international, multicentric study Open
Objectives Autoimmune gastritis (AIG) has been poorly described in childhood. We sought to identify the patterns of manifestations of pediatric AIG at onset and to describe its laboratory, clinical, and histopathological features. Methods …
View article: Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: A single-center, preliminary study
Factors associated with comorbidity in hospitalized and non-hospitalized inflammatory bowel disease patients: A single-center, preliminary study Open
Background Inflammatory bowel disease (IBD) may be burdened by other comorbid conditions. We herein sought to assess comorbidity in hospitalized and non-hospitalized IBD patients. Methods This was part of the San MAtteo Complexity (SMAC) s…
View article: Immunological and clinical overlap between autoimmune gastritis and autoimmune liver diseases: a prospective cohort study
Immunological and clinical overlap between autoimmune gastritis and autoimmune liver diseases: a prospective cohort study Open
Background Autoimmune gastritis (AIG) and autoimmune liver diseases (AILDs)—including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC)—are chronic organ-specific immune-mediated disord…
View article: Disrupted mucosal vascular barrier in eosinophilic esophagitis
Disrupted mucosal vascular barrier in eosinophilic esophagitis Open
Esophageal barrier has been investigated until now on the epithelial side only. Gut vascular barrier dysfunction has been recently implicated in a number of immune-mediated gastrointestinal disorders. We here characterized the esophageal v…
View article: Clinical and atopic features of patients with wheat allergy dependent on augmentation factors (WALDA) presenting with urticaria: a monocentric study
Clinical and atopic features of patients with wheat allergy dependent on augmentation factors (WALDA) presenting with urticaria: a monocentric study Open
Background. Clinical and laboratory features of wheat allergy dependent on augmentation factor (WALDA) are scarcely characterised as compared to wheat anaphylaxis dependent on augmentation factor (WANDA). In this study we assessed t…
View article: The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway
The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway Open
Introduction The impact of H. pylori infection on the efficacy of trastuzumab in HER2-positive gastric cancer (GC) remains poorly understood, despite growing evidence that tumor microenvironment and host-pathogen interactions influence the…
View article: HER2, HER3, and Mismatch Repair Protein Expression in Stage IV Small Bowel Adenocarcinoma: Results From a Multicenter Series
HER2, HER3, and Mismatch Repair Protein Expression in Stage IV Small Bowel Adenocarcinoma: Results From a Multicenter Series Open
Small bowel adenocarcinoma (SBA) is a rare and aggressive malignancy. One-third of SBA cases are diagnosed at an advanced stage, often with limited treatment options. Recent clinical trials have underscored the importance of testing predic…
View article: Correlates of Polypharmacy and Prescription Changes in Internal Medicine: a Prospective Five-Year Study
Correlates of Polypharmacy and Prescription Changes in Internal Medicine: a Prospective Five-Year Study Open
View article: Latent class analysis identifies novel coeliac disease subgroups with distinctive clinical features: a multicentric study
Latent class analysis identifies novel coeliac disease subgroups with distinctive clinical features: a multicentric study Open
View article: A comparative study of different assays for autoantibodies detection in patients with autoimmune gastritis
A comparative study of different assays for autoantibodies detection in patients with autoimmune gastritis Open
FEIA offers superior diagnostic accuracy for APCA and AIFA testing in AIG. The highest diagnostic yield for AIG is observed when both APCA and AIFA are assessed. This approach could be clinically applicable in the screening for AIG and dia…
View article: Clinical and Endoscopic-Histological Features of Multifocal and Corpus-Restricted Atrophic Gastritis Patients With Non-Cardia Gastric Cancer or Dysplasia: A Multicenter, Cross-Sectional Study
Clinical and Endoscopic-Histological Features of Multifocal and Corpus-Restricted Atrophic Gastritis Patients With Non-Cardia Gastric Cancer or Dysplasia: A Multicenter, Cross-Sectional Study Open
INTRODUCTION: Helicobacter pylori (Hp)-related atrophic gastritis (AG) affects corpus and antral mucosa, resulting in multifocal AG (MF-AG); autoimmunity-driven AG is corpus-restricted (CR-AG). AG carries increased gastric dysplasia (GD) a…
View article: Effect of seasonal exposure in aeroallergen-sensitised patients with irritable bowel syndrome-diarrhoea
Effect of seasonal exposure in aeroallergen-sensitised patients with irritable bowel syndrome-diarrhoea Open
Background Pollen allergy may influence irritable bowel syndrome (IBS) symptoms; however, available data are scant. Aims This study aims to assess symptom variability in atopic IBS patients. Methods We retrospectively analysed consecutive …
View article: Factors driving persistence to first-line advanced therapies in inflammatory bowel disease: a real-world study from a tertiary referral centre
Factors driving persistence to first-line advanced therapies in inflammatory bowel disease: a real-world study from a tertiary referral centre Open
Factors driving the persistence of advanced therapies—defined as the duration from therapy initiation to discontinuation—in inflammatory bowel disease (IBD) remain unclear. This study aimed to evaluate the persistence of biologics and oral…
View article: Clinical Heterogeneity of Early-Onset Autoimmune Gastritis: From the Evidence to a Pediatric Tailored Algorithm
Clinical Heterogeneity of Early-Onset Autoimmune Gastritis: From the Evidence to a Pediatric Tailored Algorithm Open
Autoimmune gastritis (AIG) is an uncommon and often underestimated condition in children, characterized by chronic stomach inflammation leading to the destruction of oxyntic glands with subsequent atrophic and metaplastic changes. This con…
View article: European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption
European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption Open
Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in …
View article: Meta‐Analysis: Pregnancies With Inflammatory Bowel Disease Complicated by Intrahepatic Cholestasis of Pregnancy
Meta‐Analysis: Pregnancies With Inflammatory Bowel Disease Complicated by Intrahepatic Cholestasis of Pregnancy Open
Background Inflammatory Bowel Disease (IBD) requires maintenance of remission during pregnancy to avoid poor maternal and fetal outcomes. Intrahepatic cholestasis of pregnancy (ICP) could also increase these risks. Aims To examine the prev…
View article: European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN
European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN Open
Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in …
View article: Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen
Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen Open
Splenectomy or congenital asplenia is associated with severe reduction of memory B cells and increased risk of fulminant sepsis by encapsulated bacteria. Current guidelines recommend vaccinations against these pathogens before or after spl…
View article: Long-term Prognosis of Nonceliac Enteropathies and a Score to Identify Patients With Poor Outcomes: A 30-year Multicenter Longitudinal Study
Long-term Prognosis of Nonceliac Enteropathies and a Score to Identify Patients With Poor Outcomes: A 30-year Multicenter Longitudinal Study Open
INTRODUCTION: Long-term prognosis of nonceliac enteropathies (NCEs) is poorly understood. We aimed to evaluate long-term outcomes and develop a prognostic score for NCEs. METHODS: NCEs patients from an international multicenter cohort (4 I…
View article: Coeliac disease and chronic liver disease: a double-face issue
Coeliac disease and chronic liver disease: a double-face issue Open
View article: A Comparative Study of Different Assays for Autoantibodies Detection in Patients with Autoimmune Gastritis
A Comparative Study of Different Assays for Autoantibodies Detection in Patients with Autoimmune Gastritis Open
View article: Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease
Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease Open
Background and Aims Given the role of Receptor for Activated C Kinase 1 (RACK1) in both immune cell activation and in the maintenance of the intestinal epithelial barrier integrity, we investigated whether it was involved in inflammatory b…
View article: <scp>LINE</scp> ‐1 hypomethylation characterizes the inflammatory response in coeliac disease associated‐intestinal mucosa and small bowel adenocarcinomas
<span>LINE</span> ‐1 hypomethylation characterizes the inflammatory response in coeliac disease associated‐intestinal mucosa and small bowel adenocarcinomas Open
Long interspersed nuclear elements 1 (LINE‐1) are the most abundant and the only autonomous mobile elements in the human genome. When their epigenetic repression is removed, it can lead to disease, such as autoimmune diseases and cancer. C…
View article: Pinworm Infection Misdiagnosed With Primary Eosinophilic Colitis. A Case Series
Pinworm Infection Misdiagnosed With Primary Eosinophilic Colitis. A Case Series Open
Parasitic infections make it difficult to establish a diagnosis of primary eosinophilic gastrointestinal disorders (EGID), may even co-occur with inflammatory bowel disease and complicate the management of patients treated with immunosuppr…
View article: Nutritional Consequences of Celiac Disease and Gluten-Free Diet
Nutritional Consequences of Celiac Disease and Gluten-Free Diet Open
Celiac disease is an immune-mediated condition triggered by gluten ingestion in genetically predisposed individuals. The global prevalence of celiac disease is significant, affecting approximately 1.4% of women and 0.7% of men, with incide…
View article: Medullary carcinomas of the nonampullary small intestine: association with coeliac disease, mismatch repair deficiency, PD‐L1 expression, and favourable prognosis
Medullary carcinomas of the nonampullary small intestine: association with coeliac disease, mismatch repair deficiency, PD‐L1 expression, and favourable prognosis Open
Aim Gastrointestinal medullary carcinoma is a rare histologic subtype of adenocarcinoma. As nonampullary small bowel medullary carcinomas (SB‐MCs) are poorly characterized, we aimed to analyse their clinicopathologic and immunohistochemica…
View article: Navigating the transition: a multidisciplinary approach to inflammatory bowel disease in children
Navigating the transition: a multidisciplinary approach to inflammatory bowel disease in children Open
View article: Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy
Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy Open
Autoimmune gastritis (AIG) is an autoimmune disorder characterized by the destruction of gastric parietal cells and atrophy of the oxyntic mucosa which induces intrinsic factor deficiency and hypo-achlorhydria. AIG predominantly affects th…