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View article: Platelet Activation Is Limited during Transcatheter Aortic Valve Implantation in Patients on Aspirin Monotherapy and without per Procedural Clinical Complications
Platelet Activation Is Limited during Transcatheter Aortic Valve Implantation in Patients on Aspirin Monotherapy and without per Procedural Clinical Complications Open
Transcatheter aortic valve implantation (TAVI) is an established treatment option for symptomatic patients with severe aortic valve stenosis (AS). During and early after the procedure, both ischemic events (predominantly stroke) and bleedi…
View article: Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions
Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions Open
While efficient at treating B-cell malignancies, Bruton tyrosine kinase (BTK) inhibitors are consistently reported to increase the risk of bleeding. Analyzing platelet aggregation response to collagen in platelet-rich plasma allowed us to …
View article: A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth Open
Key Points Vps34 controls intracellular trafficking, migration, and platelet production in MKs. Vps34 and its stimulation-dependent PI3P production regulate platelet secretion and thrombus growth.