Sara M. Lippa
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View article: Unhealthy family functioning is strongly associated with warfighter brain health following traumatic brain injury in United States service members and veterans
Unhealthy family functioning is strongly associated with warfighter brain health following traumatic brain injury in United States service members and veterans Open
Objective To examine the relationship between family functioning and health-related quality of life (HRQOL) outcomes following traumatic brain injury (TBI) in service members and veterans (SMVs). Participants Participants were 359 United S…
View article: Family risk factors are related to warfighter brain health: A dyadstudy.
Family risk factors are related to warfighter brain health: A dyadstudy. Open
An important and unique addition to the literature was the finding that a range of risk factors in the warfighter's family environment were strongly associated with clinically elevated chronic neurobehavioral symptoms following a TBI of an…
View article: Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures
Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures Open
View article: Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis
Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis Open
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by ev…
View article: Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI
Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI Open
BACKGROUND We examined spatial patterns of brain atrophy after mild, moderate, and severe traumatic brain injury (TBI), the relationship between progression of brain atrophy with initial traumatic axonal injury (TAI), cognitive outcome, an…
View article: Neuroimaging Findings in US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Neuroimaging Findings in US Government Personnel and Their Family Members Involved in Anomalous Health Incidents Open
Importance US government personnel stationed internationally have reported anomalous health incidents (AHIs), with some individuals experiencing persistent debilitating symptoms. Objective To assess the potential presence of magnetic reson…
View article: Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents
Clinical, Biomarker, and Research Tests Among US Government Personnel and Their Family Members Involved in Anomalous Health Incidents Open
Importance Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous healt…
View article: Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study
Serum GFAP, NfL, and tau concentrations are associated with worse neurobehavioral functioning following mild, moderate, and severe TBI: a cross-sectional multiple-cohort study Open
Introduction The purpose of this study was to examine whether blood-based biomarkers associate with neurobehavioral functioning at three time points following traumatic brain injury (TBI). Materials and methods Participants were 328 United…
View article: Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury
Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury Open
View article: An Emotion-Driven Vocal Biomarker-Based PTSD Screening Tool
An Emotion-Driven Vocal Biomarker-Based PTSD Screening Tool Open
Goal: This paper introduces an automated post-traumatic stress disorder (PTSD) screening tool that could potentially be used as a self-assessment or inserted into routine medical visits to aid in PTSD diagnosis and treatment. Met…
View article: Efficient Estimation of the Binaural Masking Level Difference Using a Technique Based on Manual Audiometry
Efficient Estimation of the Binaural Masking Level Difference Using a Technique Based on Manual Audiometry Open
Purpose: The Masking Level Difference (MLD) has been used for decades to evaluate the binaural listening advantage. Although originally measured using Bekesy audiometry, the most common clinical use of the MLD is the CD-based Wilson 500-Hz…
View article: Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury
Lifetime Blast Exposure Is Not Related to White Matter Integrity in Service Members and Veterans With and Without Uncomplicated Mild Traumatic Brain Injury Open
This study examines the impact of lifetime blast exposure on white matter integrity in service members and veterans (SMVs). Participants were 227 SMVs, including those with a history of mild traumatic brain injury (mTBI; n = 124), orthoped…
View article: Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium
Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium Open
Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample sizes, statistical power, and representativeness of data. These efforts unveil new questions about integrating data ar…
View article: Varying failure criteria on performance validity tests influences interpretation of cognitive outcomes.
Varying failure criteria on performance validity tests influences interpretation of cognitive outcomes. Open
Methods of defining PVT failure can greatly influence differences in cognitive function between groups defined by PTS symptom levels. Findings highlight the importance of considering performance validity when interpreting cognitive data an…
View article: A-15 Impact of Lifetime Blast Exposure on Cognitive and Psychiatric Functioning of Warfighters
A-15 Impact of Lifetime Blast Exposure on Cognitive and Psychiatric Functioning of Warfighters Open
Objective: Some military occupation specialties (MOS) such as Special Forces are at high risk for lifetime blast exposure (LBE). These individuals are at risk for some medical conditions but the impact of LBE on service members and veteran…
View article: A-178 18F-Fluorodeoxyglucose Positron Emission Tomography Findings Are Not Related to Cognitive Functioning in Service Members with Remote History of Traumatic Brain Injury
A-178 18F-Fluorodeoxyglucose Positron Emission Tomography Findings Are Not Related to Cognitive Functioning in Service Members with Remote History of Traumatic Brain Injury Open
Objective: Determine whether glucose uptake as measured by 18F-Fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is associated with cognitive performance and mild neurocognitive disorder (MNCD) in active-duty service member…
View article: APOE Is Associated With Serum Tau Following Uncomplicated Mild Traumatic Brain Injury
APOE Is Associated With Serum Tau Following Uncomplicated Mild Traumatic Brain Injury Open
Background and Objectives APOE e4 has been linked to poor outcome following traumatic brain injury (TBI); however, the mechanisms behind this relationship are unclear. Few studies have investigated the relationship between the APOE genotyp…
View article: 0625 Characterization of Obstructive Sleep Apnea in Active-Duty US Military Personnel Receiving Interdisciplinary Care at the National Intrepid Center of Excellence
0625 Characterization of Obstructive Sleep Apnea in Active-Duty US Military Personnel Receiving Interdisciplinary Care at the National Intrepid Center of Excellence Open
Introduction Among active-duty service members (ADSMs), obstructive sleep apnea (OSA) is associated with decreased quality of life and military readiness/retention. Limited evidence suggests mild traumatic brain injury (mTBI) patients have…
View article: Longitudinal changes of white matter microstructure following traumatic brain injury in U.S. military service members
Longitudinal changes of white matter microstructure following traumatic brain injury in U.S. military service members Open
The purpose of this study was to analyze quantitative diffusion tensor imaging measures across the spectrum of traumatic brain injury severity and evaluate their trajectories in military service members. Participants were 96 U.S. military …
View article: Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population
Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population Open
View article: P111 Sleep disturbances are associated with poor neurobehavioural outcomes following traumatic brain injury: A study of military service members and veterans
P111 Sleep disturbances are associated with poor neurobehavioural outcomes following traumatic brain injury: A study of military service members and veterans Open
Introduction Sleep disturbances are pervasively reported in military service members and veterans, especially following traumatic brain injury (TBI). The purpose of this study was to examine the association between sleep disturbances and n…
View article: A-15 PTSD Symptoms Are Related to Cognition Following Complicated Mild and Moderate TBI, but Not Severe and Penetrating TBI
A-15 PTSD Symptoms Are Related to Cognition Following Complicated Mild and Moderate TBI, but Not Severe and Penetrating TBI Open
Objective Despite the strong evidence suggesting post-traumatic stress disorder (PTSD) symptoms negatively impact cognition following mild traumatic brain injury (TBI), little is known about this relationship in more severe TBI. This study…
View article: A-130 Validity-10, Remaining-12 and Total NSI Scores as Measures of Symptom Validity in Service Members with a History of mTBI
A-130 Validity-10, Remaining-12 and Total NSI Scores as Measures of Symptom Validity in Service Members with a History of mTBI Open
Objective The Neurobehavioral Symptom Inventory (NSI), a commonly used self-report measure of concussive symptoms, is frequently employed throughout the Defense Health Agency. Embedded measures of symptom validity have been developed that …
View article: Sleep disturbances following traumatic brain injury are associated with poor neurobehavioral outcomes in US military service members and veterans
Sleep disturbances following traumatic brain injury are associated with poor neurobehavioral outcomes in US military service members and veterans Open
View article: White Matter Hyperintensities Are Not Related to Symptomatology or Cognitive Functioning in Service Members with a Remote History of Traumatic Brain Injury
White Matter Hyperintensities Are Not Related to Symptomatology or Cognitive Functioning in Service Members with a Remote History of Traumatic Brain Injury Open
This study aimed to determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMHs) are associated with symptom reporting and/or cognitive performance in 1202 active-duty service members with prior single or multipl…
View article: A-117 Sleep Disruption has a Stronger Influence on Self-reported Neurobehavioral Status than Traumatic Brain Injury in U.S. Military Service Members and Veterans
A-117 Sleep Disruption has a Stronger Influence on Self-reported Neurobehavioral Status than Traumatic Brain Injury in U.S. Military Service Members and Veterans Open
Objective To examine the relation between sleep disruption and neurobehavioral outcome following mild, moderate, and severe traumatic brain injury (TBI). Methods Participants were 509 U.S. military service members/veterans divided into fou…
View article: A-116 Predicting Chronic Neurobehavioral Symptoms based on Acute Injury Characteristics and Symptoms in U.S. Military Service Members with and without history of TBI
A-116 Predicting Chronic Neurobehavioral Symptoms based on Acute Injury Characteristics and Symptoms in U.S. Military Service Members with and without history of TBI Open
Objective Recovery following traumatic brain injury (TBI) is complex. Often following mild TBI, recovery occurs within days or weeks, though this is not always the case. Following more severe TBI, some recover quickly, while many never ful…
View article: A-124 Acute Predictors of Chronic PTSD Symptoms Following TBI in U.S. Military Service Members
A-124 Acute Predictors of Chronic PTSD Symptoms Following TBI in U.S. Military Service Members Open
Objective Post-Traumatic Stress Disorder (PTSD) has been shown to be a major contributor to poor outcome after Traumatic Brain Injury (TBI). Understanding the factors that contribute to PTSD symptoms may lead to improved clinical managemen…
View article: Relating Self‐Reported Balance Problems to Sensory Organization and Dual‐Tasking in Chronic Traumatic Brain Injury
Relating Self‐Reported Balance Problems to Sensory Organization and Dual‐Tasking in Chronic Traumatic Brain Injury Open
Background Individuals who have experienced a traumatic brain injury (TBI) often have residual balance problems. It remains unclear whether these balance problems are driven by vestibular dysfunction or gait automaticity deficits, particul…
View article: Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI
Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI Open
This study provides Class III evidence that serum NfL distinguishes patients with mild TBI from healthy controls.