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View article: Current practices and challenges in the management of cancer-associated thrombosis: a survey of Italian oncologists
Current practices and challenges in the management of cancer-associated thrombosis: a survey of Italian oncologists Open
Purpose This study investigates current practices and challenges in managing cancer-associated thrombosis (CAT) among Italian oncologists, with the objective of evaluating adherence to guidelines for primary thromboprophylaxis, treatment a…
View article: Sustained Partial Response Of Metastatic Castration-Resistant Prostate Cancer With Bilobar Hepatic Involvement Treated With Intra-Arterial Hepatic Chemotherapy: A Case Report
Sustained Partial Response Of Metastatic Castration-Resistant Prostate Cancer With Bilobar Hepatic Involvement Treated With Intra-Arterial Hepatic Chemotherapy: A Case Report Open
Metastatic castration-resistant prostate cancer (mCRPC) with liver metastases often has poor outcomes with conventional therapies showing limited effectiveness. This case report describes a 59-year-old man with mCRPC and extensive liver me…
View article: Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional characterization
Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional characterization Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy‐rela…
View article: A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma Open
Pleiotropic variants (i.e. genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted 10 years ago in relation to pancreatic ductal adenocarci…
View article: Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: a meta-analysis of four large European cohorts and functional characterization
Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: a meta-analysis of four large European cohorts and functional characterization Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. The vast majority of patients have unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Considering this fact, it is urgent…
View article: Persistent Müllerian Duct Syndrome and Germ Cell Tumor: A Case Report and a Review of the Literature
Persistent Müllerian Duct Syndrome and Germ Cell Tumor: A Case Report and a Review of the Literature Open
Persistent Müllerian Duct Syndrome (PMDS) is a rare disease of sexual differentiation characterized by the presence of Müllerian duct structures in a male with a normal phenotype. All patients with this condition are considered males regar…
View article: Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians Open
View article: A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma
A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma Open
Coding sequence variants comprise a small fraction of the germline genetic variability of the human genome. However, they often cause deleterious change in protein function and are therefore associated with pathogenic phenotypes. To identi…
View article: The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer Open
View article: How to become a Multinational Association of Supportive Care in Cancer-designated center of excellence in supportive care in cancer
How to become a Multinational Association of Supportive Care in Cancer-designated center of excellence in supportive care in cancer Open
Purpose of review Aim of this review is to encourage and involve more doctors to take care of supportive care in cancer patients and to become centers of excellence. Recent findings In 2019, MASCC initiated a certification program to recog…
View article: Genetic and non-genetic risk factors for early-onset pancreatic cancer
Genetic and non-genetic risk factors for early-onset pancreatic cancer Open
View article: Association between a polymorphic variant in the <i>CDKN2B‐AS1/ANRIL</i> gene and pancreatic cancer risk
Association between a polymorphic variant in the <i>CDKN2B‐AS1/ANRIL</i> gene and pancreatic cancer risk Open
Genes carrying high‐penetrance germline mutations may also be associated with cancer susceptibility through common low‐penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the…
View article: Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women Open
View article: Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk
Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk Open
Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. A recessiv…
View article: Stereotactic body radiation therapy for the treatment of pleural metastases in patients with thymoma: a retrospective review of 22 patients
Stereotactic body radiation therapy for the treatment of pleural metastases in patients with thymoma: a retrospective review of 22 patients Open
Stereotactic body radiation therapy of pleural metastases is feasible and offers a promising local control of diseases. The impact of this treatment on patients' survival is hardly predictable because of the heterogeneous clinical behavior…
View article: Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk
Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk Open
Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We ai…
View article: What to Do and What Not to Do in the Management of Cancer Pain: A Physician Survey and Expert Recommendations
What to Do and What Not to Do in the Management of Cancer Pain: A Physician Survey and Expert Recommendations Open
Oncologists require better education and training about the diagnosis, treatment, and monitoring of oncological pain. Physicians should be aware of current guideline recommendations as well as available pharmacological tools for BTcP.
View article: Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade
Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade Open
Context Thyrotoxicosis is a common immune-related adverse event in patients treated with programmed cell death protein-1 (PD1) or programmed cell death protein ligand-1 (PD-L1) blockade. A detailed endocrinological assessment, including th…
View article: Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade
Management of Thyrotoxicosis Induced by PD1 or PD-L1 Blockade Open
Context: Thyrotoxicosis is a common immune-related adverse event in patients treated with PD1 or PD-L1 checkpoint inhibitors. A detailed endocrinological assessment, including thyroid ultrasound and scintigraphy is missing, as are data on …
View article: Combining liquid biopsy and radiomics for personalized treatment of lung cancer patients. State of the art and new perspectives
Combining liquid biopsy and radiomics for personalized treatment of lung cancer patients. State of the art and new perspectives Open
View article: Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer
Integrating Liquid Biopsy and Radiomics to Monitor Clonal Heterogeneity of EGFR-Positive Non-Small Cell Lung Cancer Open
Background EGFR-positive Non-small Cell Lung Cancer (NSCLC) is a dynamic entity and tumor progression and resistance to tyrosine kinase inhibitors (TKIs) arise from the accumulation, over time and across different disease sites, of subclon…
View article: Genome‐wide association study identifies an early onset pancreatic cancer risk locus
Genome‐wide association study identifies an early onset pancreatic cancer risk locus Open
Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome‐wide association study (GWAS) to identify novel genetic…
View article: P01.044 Impact of the addition of vinorelbine to temozolomide in the first-line treatment of pediatric high grade gliomas
P01.044 Impact of the addition of vinorelbine to temozolomide in the first-line treatment of pediatric high grade gliomas Open
Pediatric high-grade gliomas (HGGs) are comprised primarily of anaplastic astrocytomas (AA, WHO-grade III) and glioblastomas (GBM, WHO-grade IV). Despite advances in treatment for other childhood tumors, their outcomes are comparable to ad…
View article: P05.26 Efficacy and tolerability of high dose chemotherapy with autologous stem cell rescue after surgery in patients with congenital brain tumors
P05.26 Efficacy and tolerability of high dose chemotherapy with autologous stem cell rescue after surgery in patients with congenital brain tumors Open
Congenital malignant brain tumors are extremely rare characterized by a poor prognosis. This could be due to a massive size of these tumors when they are diagnosed, the surgical difficulties and the lack of consolidated therapeutic approac…
View article: Sirolimus in Infants with Multiple Cardiac Rhabdomyomas Associated with Tuberous Sclerosis Complex
Sirolimus in Infants with Multiple Cardiac Rhabdomyomas Associated with Tuberous Sclerosis Complex Open
Introduction: Cardiac rhabdomyomas represent a frequent manifestation of tuberous sclerosis. Tumor growth, mainly prenatally, can result in intrauterine fetal or neonatal deaths in almost 10% of patients. Case Report:
View article: Medical treatment of malignant pleural mesothelioma relapses
Medical treatment of malignant pleural mesothelioma relapses Open
There are not established treatments for patients with advanced malignant pleural mesothelioma that progressed after first-line chemotherapy with cisplatin and pemetrexed. Retrospective analyses suggest a possible role for rechallenge with…
View article: Quality of nursing home care: preliminary results from Tuscany region (Italy)
Quality of nursing home care: preliminary results from Tuscany region (Italy) Open
Nursing home care is defined as the healthcare and social interventions for particularly fragile patients directly in their homes, with the aim to stabilize their clinical condition, to limit the functional decline and to improving the qua…
View article: Spinal Cord Involvement in Two Children With Posterior Reversible Encephalopathy Syndrome
Spinal Cord Involvement in Two Children With Posterior Reversible Encephalopathy Syndrome Open
Spinal cord involvement (SCI) is a rare feature of posterior reversible encephalopathy syndrome (PRES), especially in children. SCI is generally symptomatic, and may have a different outcome compared with encephalic localization of PRES. W…
View article: Tumor response of temozolomide in combination with morphine in a xenograft model of human glioblastoma
Tumor response of temozolomide in combination with morphine in a xenograft model of human glioblastoma Open
Despite multimodal treatments comprising, radiation therapy (RT) and chemotherapy with temozolomide (TMZ), the prognosis of glioblastoma multiforme (GBM) remains dismal and consolidated therapy yields a median survival of 14.6 months. Bloo…
View article: Role of eculizumab in a pediatric refractory gemcitabine-induced thrombotic microangiopathy: a case report
Role of eculizumab in a pediatric refractory gemcitabine-induced thrombotic microangiopathy: a case report Open