Michael S. Block
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View article: Use of Biomarkers in Nutrition Intervention Studies of Children: A Scoping Review
Use of Biomarkers in Nutrition Intervention Studies of Children: A Scoping Review Open
Obesity in youth is an increasingly prevalent public health concern worldwide. Lifestyle interventions aim to help participants establish healthy habits and reduce obesity-related disease risk by targeting physical activity and dietary hab…
View article: Endodontic Microsurgery Using Dynamic Navigation and Trephine Burs
Endodontic Microsurgery Using Dynamic Navigation and Trephine Burs Open
Objectives: The use of the surgical operating microscope, CBCT imagining, biocompatible filling materials and ultrasonic instruments have improved the success and predictability of apical surgery. Despite these advances, more accurate and …
View article: Predictive Performance of Physiology‐Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small‐Molecule Compounds in Children
Predictive Performance of Physiology‐Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small‐Molecule Compounds in Children Open
Development and guidance of dosing schemes in children have been supported by physiology‐based pharmacokinetic (PBPK) modeling for many years. PBPK models are built on a generic basis, where compound‐ and system‐specific parameters are sep…
View article: Digital assisted soft tissue sculpturing (DASS) technique for immediate loading pink free complete arch implant prosthesis
Digital assisted soft tissue sculpturing (DASS) technique for immediate loading pink free complete arch implant prosthesis Open
The DASS technique is a predictable integrated digital workflow that simplifies the achievement of a scalloped tissue interface for pink free fixed implant prosthesis, reestablishing the mucosal dimension required for the protection of und…
View article: Correction to: Protected risk stratification with the wearable cardioverter-defibrillator: results from the WEARIT-II-EUROPE registry
Correction to: Protected risk stratification with the wearable cardioverter-defibrillator: results from the WEARIT-II-EUROPE registry Open
The original version of this article unfortunately contained mistakes.
View article: Emergent airway management outside of the operating room – a retrospective review of patient characteristics, complications and ICU stay
Emergent airway management outside of the operating room – a retrospective review of patient characteristics, complications and ICU stay Open
Background Emergent airway management outside of the operating room is a high-risk procedure. Limited data exists about the indication and physiologic state of the patient at the time of intubation, the location in which it occurs, or pati…
View article: Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland
Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland Open
We extended a generic whole-body physiologically based pharmacokinetic (PBPK) model for rats and humans for organs of the reproductive and endocrine systems (i.e., the testes and the thyroid gland). An extensive literature search was perfo…
View article: Addressing Adherence Using Genotype-Specific PBPK Modeling—Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels
Addressing Adherence Using Genotype-Specific PBPK Modeling—Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels Open
Introduction: Tamoxifen is one of the most common treatment opportunities for hormonal positive breast cancer. Despite its good tolerability, patients demonstrate decreasing adherence over years impacting on therapeutic success. PBPK model…
View article: Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model Open
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow.…