Cynthia M. Magro
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View article: Primary cutaneous follicle center lymphoma presenting as frontal fibrosing alopecia
Primary cutaneous follicle center lymphoma presenting as frontal fibrosing alopecia Open
Primary cutaneous follicle center lymphoma rarely presents as macular alopecia and is typically characterized by solitary papules and nodules on the head, neck, and trunk. We report a 24-year-old woman with frontal alopecia that clinically…
View article: Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoproliferative Disorder: A Retrospective Cohort Study of 40 Adult Patients
Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoproliferative Disorder: A Retrospective Cohort Study of 40 Adult Patients Open
Primary cutaneous CD4 + small/medium-sized T-cell lymphoproliferative disorder (CD4 + PCSM-LPD) is distinguished from other peripheral T-cell lymphomas, particularly multifocal variants, by its indolent clinical behavior and favorable prog…
View article: Pediatric CD4+ Small Medium Sized Pleomorphic T-cell Lymphoproliferative Disorder: A Unique Indolent Lymphoproliferative Lesion With Consistent Reproducible Clinical and Phenotypic Features
Pediatric CD4+ Small Medium Sized Pleomorphic T-cell Lymphoproliferative Disorder: A Unique Indolent Lymphoproliferative Lesion With Consistent Reproducible Clinical and Phenotypic Features Open
Primary cutaneous CD4 + small/medium-sized pleomorphic T-cell lymphoproliferative disorder (CD4 + PCSM-LPD) is characterized by its indolent course and favorable prognosis, distinguishing it from multifocal variants or other peripheral T-c…
View article: Melanoma and Matrimony: Retrospective Study of Demographics, Marital Status, and Clinical Features of Patients With Acral Melanoma at a Single Academic Center
Melanoma and Matrimony: Retrospective Study of Demographics, Marital Status, and Clinical Features of Patients With Acral Melanoma at a Single Academic Center Open
Acral melanoma (AM) is localized to the hands and feet including the palms, soles, fingers, toes, and nails, and is associated with a high degree of morbidity and mortality. It has a greater proportional incidence in non‐White patients and…
View article: Giant cellulitis-like Sweet syndrome with myofasciitis: Multimodality imaging findings and streptococcal trigger
Giant cellulitis-like Sweet syndrome with myofasciitis: Multimodality imaging findings and streptococcal trigger Open
Sweet syndrome is a rare neutrophilic dermatosis that can mimic infectious cellulitis. In this case, a 34-year-old woman presented to the emergency department with fever, leukocytosis, and painful erythematous right thigh plaque. She was i…
View article: Primary cutaneous plasmacytosis in a woman with previously undiagnosed celiac disease
Primary cutaneous plasmacytosis in a woman with previously undiagnosed celiac disease Open
Cutaneous plasmacytosis has <60 cases worldwide, typically characterized by multiple asymmetric facial and truncal cutaneous nodules and plaques. We describe the case of a 68-year-old woman with erythematous plaques on the feet who had a b…
View article: Primary Cutaneous Methotrexate-Associated T-Cell Lymphoproliferative Disorder in the Setting of Autoimmune Disease: A Case Series and Review of the Literature
Primary Cutaneous Methotrexate-Associated T-Cell Lymphoproliferative Disorder in the Setting of Autoimmune Disease: A Case Series and Review of the Literature Open
Methotrexate (MTX), an antimetabolite targeting certain autoimmune conditions and various hematologic malignancies, has been associated with iatrogenic lymphoproliferative disease (LPD) primarily of B-cell lineage. Less commonly are T-cell…
View article: The Cutaneous Pathology of Erythromelalgia and Its Role in Establishing Critical Clues Regarding Pathogenesis
The Cutaneous Pathology of Erythromelalgia and Its Role in Establishing Critical Clues Regarding Pathogenesis Open
Erythromelalgia, a rare cutaneous pain syndrome, is characterized by acral burning pain and flushing, often alleviated by cold and rest. Primary erythromelalgia is caused by gain-of-function mutations of genes encoding for sodium channels,…
View article: Pigmented Malignant Onychopapilloma of the Fingernail: Description of the “String Sign”
Pigmented Malignant Onychopapilloma of the Fingernail: Description of the “String Sign” Open
Onychopapilloma is a benign nail tumor of the nail bed and distal matrix that typically presents as isolated longitudinal erythronychia on clinical examination. In 2021, Haneke et. al described the first case of a malignant variant of onyc…
View article: Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature
Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature Open
Pyoderma gangrenosum (PG) is a rare necrotizing neutrophilic dermatosis driven by monokines and cytokines elaborated by monocytes and autoreactive T cells, respectively. Th1‐mediated autoimmune disorders and myeloproliferative disease are …
View article: Redefining Calciphylaxis as a Uniquely Bone Forming Subcutaneous C5b-9–Mediated Microvascular Injury Syndrome Associated With Localized Subcutaneous and Systemic Complement Pathway Activation
Redefining Calciphylaxis as a Uniquely Bone Forming Subcutaneous C5b-9–Mediated Microvascular Injury Syndrome Associated With Localized Subcutaneous and Systemic Complement Pathway Activation Open
Background: Microvascular thrombosis is key to the pathogenesis of calciphylaxis. C5b-9–mediated microvascular injury reflective of complement pathway activation could be a key pathophysiologic event. Methods: We conducted a retrospective …
View article: The utility of the normal thin section skin biopsy in the assessment of systemic/extracutaneous disease and small fiber neuropathy
The utility of the normal thin section skin biopsy in the assessment of systemic/extracutaneous disease and small fiber neuropathy Open
Diseases reflective of multiorgan vascular injury of diverse etiology, peripheral nerve disease, dysautonomia syndromes, and intravascular lymphoma may exhibit abnormalities on a normal skin biopsy that may be instrumental in establishing …
View article: Tumor necrosis factor ALPHA Inhibitor Associated Köhlmeier–Degos Disease as a Novel Iatrogenic Paradigm That Underscores Excessive Type I Interferon in Its Pathogenesis
Tumor necrosis factor ALPHA Inhibitor Associated Köhlmeier–Degos Disease as a Novel Iatrogenic Paradigm That Underscores Excessive Type I Interferon in Its Pathogenesis Open
Malignant atrophic papulosis/Köhlmeier–Degos disease was first described in 1941 by Köhlmeier in an anecdotal case report that described a young man who presented with extensive multiple intestinal perforations and a papular skin rash. Köh…
View article: Expanding the Differential Diagnosis of the Painful Nail: A Case of an Onychopapilloma with Neuroma
Expanding the Differential Diagnosis of the Painful Nail: A Case of an Onychopapilloma with Neuroma Open
Introduction: Onychopapilloma most commonly presents as longitudinal erythronychia, but diagnosis may be challenging in some cases due to varied clinical presentations. Most patients with onychopapillomas do not report associated pain but …
View article: Exploring Cutaneous Lymphoproliferative Disorders in the Wake of COVID-19 Vaccination
Exploring Cutaneous Lymphoproliferative Disorders in the Wake of COVID-19 Vaccination Open
Background Individual reports have described lymphoproliferative disorders (LPDs) and cutaneous lymphomas emerging after administration of the COVID-19 vaccine; however, the relationship between reactions and vaccine types has not yet been…
View article: Horrifying Basal Cell Carcinoma Presenting as Progressive Pyoderma Gangrenosum: Case Report
Horrifying Basal Cell Carcinoma Presenting as Progressive Pyoderma Gangrenosum: Case Report Open
Introduction: Skin ulcers can be challenging to diagnose and manage, particularly with comorbid autoimmune and gastrointestinal diseases. Occam’s razor encourages the simplest explanation to guide care, but reconsideration must occur when …
View article: Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma
Cutaneous type IV hypersensitivity reaction following tebentafusp treatment for uveal melanoma Open
Tebentafusp is a bispecific protein that recently underwent FDA approval for the treatment of metastatic uveal melanoma that functions by redirecting cytotoxic T cells to glycoprotein-100, a protein highly expressed in melanoma. Although c…
View article: Relapsing White Matter Disease and Subclinical Optic Neuropathy
Relapsing White Matter Disease and Subclinical Optic Neuropathy Open
A 16-year-old adolescent boy presented with recurrent episodes of weakness and numbness. Brain MRI demonstrated subcortical, juxtacortical, and periventricular white matter T2 hyperintensities with gadolinium enhancement. CSF was positive …
View article: Microvascular C5b-9 deposition in non-lesional skin in patients with SLE and its correlation with active lupus nephritis: a prospective observational study
Microvascular C5b-9 deposition in non-lesional skin in patients with SLE and its correlation with active lupus nephritis: a prospective observational study Open
Objective Tissue damage in lupus nephritis (LN) is mediated by activation of the classical complement pathway. Complement-mediated upregulation of endothelial cell adhesion molecules is seen in dermal blood vessels of non-lesional skin of …
View article: Mycosis fungoides diagnosed after exposure to risankizumab for psoriasis
Mycosis fungoides diagnosed after exposure to risankizumab for psoriasis Open
Although biologics are increasingly used to treat inflammatory dermatoses, concerns have been raised about their long-term safety. There is an established link between tumor necrosis factor-α inhibitors and cutaneous T-cell lymphoma (CTCL)…