Alberto Mantovani
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View article: A machine learning model including pentraxin-3 as predictor of outcomes in community-acquired pneumonia
A machine learning model including pentraxin-3 as predictor of outcomes in community-acquired pneumonia Open
NCT06491004 (ClinicalTrials.gov).
View article: Tissue-specific anti-tumor NK cell subsets identified in colorectal cancer liver metastases express candidate therapeutic targets
Tissue-specific anti-tumor NK cell subsets identified in colorectal cancer liver metastases express candidate therapeutic targets Open
Liver metastases are relatively resistant to checkpoint blockade immunotherapy. The hepatic tissue has distinctive features including high numbers of NK cells. It was therefore important to conduct in depth single-cell analysis of NK cells…
View article: Safety and efficacy of the feed additives cobalt(II) acetate tetrahydrate, cobalt(II) carbonate, cobalt(II) carbonate hydroxide (2:3) monohydrate and cobalt(II) sulphate heptahydrate for bovines with a functional rumen, equidae, lagomorphs, rodents, herbivore reptiles, zoo mammals and camelids (Regal B.V.)
Safety and efficacy of the feed additives cobalt(II) acetate tetrahydrate, cobalt(II) carbonate, cobalt(II) carbonate hydroxide (2:3) monohydrate and cobalt(II) sulphate heptahydrate for bovines with a functional rumen, equidae, lagomorphs, rodents, herbivore reptiles, zoo mammals and camelids (Regal B.V.) Open
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of cobalt(II) acetate tetrahydrate, cobalt(II) carbonate, cobalt(II) carbonate hydroxide (2:3) monohydrate and coba…
View article: Chemokine receptors in GtoPdb v.2025.3
Chemokine receptors in GtoPdb v.2025.3 Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [460, 459, 32, 125]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically …
View article: Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis
Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis Open
MS4A4A belongs to the MS4A tetraspan protein superfamily and is selectively expressed by the monocyte–macrophage lineage. In this study, we aimed to evaluate the role of MS4A4A+ macrophages in rheumatoid arthritis (RA) pathogenesis and res…
View article: Estudo teórico para melhoria da trava de segurança de um religador automático tripolar (Onix)
Estudo teórico para melhoria da trava de segurança de um religador automático tripolar (Onix) Open
View article: Microbial Determinants of Immune Activation and Clinical Outcome in Lung Tumor Subtypes
Microbial Determinants of Immune Activation and Clinical Outcome in Lung Tumor Subtypes Open
The tumor-associated microbiome is increasingly recognized as a critical modulator of cancer progression and therapy response, yet its composition and functional relevance in human lung tumors remain poorly defined. In this study, we profi…
View article: P-197 The long pentraxin PTX3 as cumulus oophorous extracellular matrix marker of follicular development, oocyte maturity, and embryo quality in human assisted reproduction
P-197 The long pentraxin PTX3 as cumulus oophorous extracellular matrix marker of follicular development, oocyte maturity, and embryo quality in human assisted reproduction Open
Study question Does the cumulus oophorous complex (COC) extracellular matrix (ECM) hold potential as a marker of oocyte quality and developmental competence in human assisted reproduction? Summary answer PTX3, a component of the COC ECM, i…
View article: Monocyte-macrophage membrane expression of IL-1R2 is a severity biomarker in sepsis
Monocyte-macrophage membrane expression of IL-1R2 is a severity biomarker in sepsis Open
Interleukin-1 (IL-1)/IL-1 receptor family consists of activators and inhibitors which play a key role in inflammation, emergency myelopoiesis, and myeloid cell activation. The latter includes the IL-1R2 decoy receptor. To investigate the e…
View article: Chemokine receptors in GtoPdb v.2025.1
Chemokine receptors in GtoPdb v.2025.1 Open
Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [459, 458, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically posse…
View article: The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Open
View article: Multi-Omics Identifies Oxidative Stress, Prothrombotic Pathways, and Lactoperoxidase Variants as Key Factors in COVID-19 Severity
Multi-Omics Identifies Oxidative Stress, Prothrombotic Pathways, and Lactoperoxidase Variants as Key Factors in COVID-19 Severity Open
View article: Selective expression and significance of ACKR2 in lung aerocytes
Selective expression and significance of ACKR2 in lung aerocytes Open
Background ACKR2 is an atypical chemokine receptor that plays a significant role in regulating inflammation by binding to inflammatory CC chemokines and facilitating their degradation. Previous findings suggest that the genetic absence of …
View article: Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity
Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity Open
View article: Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva
Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva Open
We investigate the role of homeostatic mechanisms involved in acute, postprandial nutrient metabolism and nutrient-induced systemic inflammation in CKD presence and progression in Metabolic dysfunction-associated steatohepatitis (MASH). We…
View article: PTX3 is expressed in terminal lymphatics and shapes their organization and function
PTX3 is expressed in terminal lymphatics and shapes their organization and function Open
Introduction The lymphatic system is a multifaceted regulator of tissue homeostasis and an integral part of immune responses. Previous studies had shown that subsets of lymphatic endothelial cells (LEC) express PTX3 , an essential componen…
View article: Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts
Depicting the cellular complexity of pancreatic adenocarcinoma by Imaging Mass Cytometry: focus on cancer-associated fibroblasts Open
Introduction Pancreatic ductal adenocarcinoma (PDAC) represents the complexity of interaction between cancer and cells of the tumor microenvironment (TME). Immune cells affect tumor cell behavior, thus driving cancer progression. Cancer-as…
View article: Macrophage diversity in cancer dissemination and metastasis
Macrophage diversity in cancer dissemination and metastasis Open
View article: BTN2A1 targeting reprograms M2-like macrophages and TAMs via SYK and MAPK signaling
BTN2A1 targeting reprograms M2-like macrophages and TAMs via SYK and MAPK signaling Open
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across dive…
View article: The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19
The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19 Open
View article: Supplementary Figures from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Figures from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Figures 1-7 with legends
View article: Supplementary Table 2 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Table 2 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Table 2
View article: Supplementary Table 2 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Table 2 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Table 2
View article: Supplementary Table 1 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Table 1 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Table 1
View article: Supplementary Figures from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Figures from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Figures 1-7 with legends
View article: Supplementary Table 1 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Supplementary Table 1 from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Supplementary Table 1
View article: Data from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer
Data from CCRL2 expression by specialized lung capillary endothelial cells controls NK-cell homing in lung cancer Open
Patterns of receptors for chemotactic factors regulate the homing of leukocytes to tissues. Here we report that the CCRL2/chemerin/CMKLR1 axis represents a selective pathway for the homing of NK cells to the lung. C-C motif Chemokine Recep…
View article: The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Open
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy…
View article: The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19
The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19 Open
View article: Outcomes of patients with advanced solid tumors who discontinued immune-checkpoint inhibitors: a systematic review and meta-analysis
Outcomes of patients with advanced solid tumors who discontinued immune-checkpoint inhibitors: a systematic review and meta-analysis Open