M. Mark Melin
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View article: Space-Related Dermatoses (SRD)
Space-Related Dermatoses (SRD) Open
View article: 0915 Impact of spaceflight on cutaneous carcinogenesis: Microgravity, hypergravity, and radiation
0915 Impact of spaceflight on cutaneous carcinogenesis: Microgravity, hypergravity, and radiation Open
View article: Space Oncology: A Comprehensive Scoping Review
Space Oncology: A Comprehensive Scoping Review Open
Space exploration exposes astronauts to unique conditions such as microgravity and space radiation, potentially influencing gene expression and triggering carcinogenesis. Paradoxically, these extreme environments could uncover other pro-tr…
View article: Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema
Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema Open
A previous report of 4 heterogeneous cases demonstrated that automated manual lymphatic drainage therapy (AMLDT), administered by a novel, pneumatic mat of 16 pressurized air channels that inflate and deflate sequentially to mimic the stre…
View article: Wound-healing and onboard care during long-duration human deep space exploration from a surgical perspective through the lens of a scoping review
Wound-healing and onboard care during long-duration human deep space exploration from a surgical perspective through the lens of a scoping review Open
View article: Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence Study
Clinical Efficacy of Ovine Forestomach Matrix and Collagen/Oxidised Regenerated Cellulose for the Treatment of Venous Leg Ulcers: A Retrospective Comparative Real‐World Evidence Study Open
Venous leg ulcers (VLUs) are traditionally managed with standard‐of‐care dressings, compression and appropriate adjunctive venous interventions for pathologic venous reflux. Due to pathophysiological complexity and underlying patient comor…
View article: Using noninvasive imaging to assess manual lymphatic drainage on lymphatic/venous responses in a spaceflight analog
Using noninvasive imaging to assess manual lymphatic drainage on lymphatic/venous responses in a spaceflight analog Open
This retrospective case series (clinicaltrials.gov NCT06405282) used noninvasive imaging devices (NIID) to assess the effect of manual lymphatic drainage (MLD) on dermal/venous fluid distribution, perfusion, and temperature alterations of …
View article: Case Report: The effect of automated manual lymphatic drainage therapy on lymphatic contractility in 4 distinct cases
Case Report: The effect of automated manual lymphatic drainage therapy on lymphatic contractility in 4 distinct cases Open
Introduction Automated manual lymphatic drainage therapy (AMLDT) is available for home use in the form of a pneumatic mat of 16 pressurized air channels that inflate and deflate to mimic the stretch and release action of manual lymphatic d…
View article: Table of contents
Table of contents Open
Radiofrequency ablation of the great saphenous vein demonstrated a high occlusion rate at 5 years of follow-up, and significantly reduced the severity of venous disease and improved patient quality of life in this retrospective study of 13…
View article: Congestive lower extremity failure: An educational model for improved understanding of phlebolymphedema
Congestive lower extremity failure: An educational model for improved understanding of phlebolymphedema Open
Lymphedema of venous etiology (phlebolymphedema) remains an under-recognized entity at many primary care clinics, vein centers, and wound centers.1Farrow W. Phlebolymphedema–A Common underdiagnosed and undertreated problem in the wound car…
View article: Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume
Optic disc edema during strict 6° head-down tilt bed rest is related to one-carbon metabolism pathway genetics and optic cup volume Open
Some astronauts on International Space Station missions experience neuroophthalmological pathologies as part of spaceflight associated neuro-ocular syndrome (SANS). Strict head-down tilt bed rest (HDTBR) is a spaceflight analog that replic…
View article: Assessing non-invasive imaging devices to detect temperature differentiation and lymphatic/venous flow to the head and neck during head down tilt, supine, and sitting positions The NIID Study (non-invasive imaging device)
Assessing non-invasive imaging devices to detect temperature differentiation and lymphatic/venous flow to the head and neck during head down tilt, supine, and sitting positions The NIID Study (non-invasive imaging device) Open
Under the influence of standard developmental physiology on the Earth’s surface (1 gravity equivalent known as “1G”), 70% of body fluids reside below the level of the heart.Fluid shifts towards the cephalic region during microgravity have …
View article: Mitigating the Post-operative Swelling Tsunami in Total Knee Arthroplasty: A Call to Action
Mitigating the Post-operative Swelling Tsunami in Total Knee Arthroplasty: A Call to Action Open
Total knee arthroplasty (TKA) is a treatment option for individuals with symptomatic osteoarthritis who have failed conservative therapy. In this manuscript the authors describe the pathophysiology of post-operative edema and explore the p…
View article: P11-057-23 Genetics of One-Carbon Metabolism Are Associated With Optic Disc Edema in a Ground-Based Model of Spaceflight
P11-057-23 Genetics of One-Carbon Metabolism Are Associated With Optic Disc Edema in a Ground-Based Model of Spaceflight Open
View article: Albumin, oral contraceptives, and venous thromboembolism risk in astronauts
Albumin, oral contraceptives, and venous thromboembolism risk in astronauts Open
We report here evidence of an association between oral contraceptive use and serum albumin, among other factors which potentially increase the risk of venous thromboembolism in astronauts. These findings highlight potential risks to astron…
View article: Retrospective real‐world comparative effectiveness of ovine forestomach matrix and collagen/<scp>ORC</scp> in the treatment of diabetic foot ulcers
Retrospective real‐world comparative effectiveness of ovine forestomach matrix and collagen/<span>ORC</span> in the treatment of diabetic foot ulcers Open
The retrospective pragmatic real‐world data (RWD) study compared the healing outcomes of diabetic foot ulcers (DFUs) treated with either ovine forestomach matrix (OFM) (n = 1150) or collagen/oxidised regenerated cellulose (ORC) (n = 1072) …
View article: Guidelines for Point-of-Care Fluorescence Imaging for Detection of Wound Bacterial Burden Based on Delphi Consensus
Guidelines for Point-of-Care Fluorescence Imaging for Detection of Wound Bacterial Burden Based on Delphi Consensus Open
Excessive levels of bacteria impede wound healing and can lead to infectious complications. Unfortunately, clinical signs and symptoms of elevated bacterial burden are often unreliable. As a result, point--of--care fluorescence imaging, us…
View article: The Synergistic, Amplifying Use of Micronized Purified Flavanoid Fraction, Proprietary Ceramide Emulsion, and Dermal Microdeformation Fuzzy Wale Compression Under Inelastic Compression for the Management of Venous Leg Ulcers
The Synergistic, Amplifying Use of Micronized Purified Flavanoid Fraction, Proprietary Ceramide Emulsion, and Dermal Microdeformation Fuzzy Wale Compression Under Inelastic Compression for the Management of Venous Leg Ulcers Open
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