Markus Böhm
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Assessment of vitiligo in clinical practice: a cross-sectional survey among experts Open
This study shows similarities but also remarkable differences in assessed outcomes compared to the CDS for clinical trials. These results serve as a preparatory step toward developing a COS for clinical practice with the involvement of exp…
View article: Well‐being in German patients with vitiligo in genital and visible areas – a pilot study
Well‐being in German patients with vitiligo in genital and visible areas – a pilot study Open
Summary Background Only a few studies exist on the psychosocial impact of vitiligo in German patients, in particular those affected in genital and visible body areas. Methods This monocentric pilot study aimed to assess well‐being of adult…
Clinical evaluation of atlas-based auto-segmentation for contouring pelvic CTVs in the treatment of anal cancer with FDG-PET-positive lymph node involvement Open
Introduction Current evidence on atlas-based auto-segmentation (ABS) in radiotherapy primarily addresses organs at risk, whereas its application for clinical target volume (CTV) delineation remains insufficiently explored. Additionally, th…
Vitiligo Open
Summary Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. Non‐segmental vitiligo (NSV) is an autoimmune disorder. The etiopathogenesis of segmental vitiligo (SV) remains incompletely understood. Gen…
View article: Vitiligo – a disease: A position paper on stigmatization, life quality impairment and psychosocial comorbidity
Vitiligo – a disease: A position paper on stigmatization, life quality impairment and psychosocial comorbidity Open
Summary Vitiligo is a common disorder characterized by the visible loss of skin pigmentation. Non‐segmental vitiligo (NSV) is the major subtype. The disease is caused by autoimmune‐mediated destruction of melanocytes. Vitiligo leads to sti…
An overview of benefits and risks of chronic melanocortin‐1 receptor activation Open
The melanocortin‐1 receptor (MC1R) is a G protein‐coupled receptor that plays a pivotal role in human skin pigmentation, melanin synthesis, redox homeostasis and inflammation. Loss‐of‐function MC1R variants suppress G protein‐coupled recep…
Issue Information Open
Our policy is to use permanent paper from mills that operate a sustainable forestry policy, and which has been manufactured from pulp that is processed using acid-free and elementary chlorine-free practices.Furthermore, we ensure that the …
Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm Open
Background The treatment of vitiligo can be challenging and depends on several factors such as the subtype, disease activity, vitiligo extent, and treatment goals. Vitiligo usually requires a long‐term approach. To improve the management o…
Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations Open
Background The treatment of vitiligo can be challenging. Up‐to‐date agreed consensus recommendations on the use of topical and systemic therapies to facilitate the clinical management of vitiligo are currently lacking. Objectives To develo…
Ultraviolet Radiation-Induced Mitochondrial Disturbances Are Attenuated by Metabolites of Melatonin in Human Epidermal Keratinocytes Open
Melatonin (N-acetyl-5-methoxytryptamine) is recognized as an effective antioxidant produced by the pineal gland, brain and peripheral organs, which also has anti-inflammatory, immunomodulatory, and anti-tumour capacities. Melatonin has bee…
Melatonin: A Potential Regulator of DNA Methylation Open
The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to pigmentation, immune regulation, and mitochondrial metabolism. Wh…
Impact of new‐onset and preexisting neurological disorders in COVID‐19 patients Open
Background and Purpose Coronavirus disease (COVID‐19) is still considered a global pandemic. The prognosis of COVID‐19 patients varies greatly. We aimed to assess the impact of preexisting, chronic neurological diseases (CNDs) and new‐onse…
Supplementary Figures S1-S4 from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line Open
Supplementary Figures S1-S4 from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line
Data from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line Open
The growth of melanocytes and many early stage melanoma cells can be inhibited by cytokines, whereas late stage melanoma cells have often been reported to be “multi-cytokine–resistant.” Here, we analyzed the melanoma cell line 1286, resist…
Data from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line Open
The growth of melanocytes and many early stage melanoma cells can be inhibited by cytokines, whereas late stage melanoma cells have often been reported to be “multi-cytokine–resistant.” Here, we analyzed the melanoma cell line 1286, resist…
Supplementary Figures S1-S4 from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line Open
Supplementary Figures S1-S4 from Constitutive Suppressor of Cytokine Signaling 3 Expression Confers a Growth Advantage to a Human Melanoma Cell Line
Systemic Sarcoidosis with Cutaneous Tattoo Involvement Following COVID-19 Vaccination Open
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Protective Role of Melatonin and Its Metabolites in Skin Aging Open
The skin, being the largest organ in the human body, is exposed to the environment and suffers from both intrinsic and extrinsic aging factors. The skin aging process is characterized by several clinical features such as wrinkling, loss of…
Autofluorescence Is a Common Trait in Different Oceanic Fungi Open
Natural autofluorescence is a widespread phenomenon observed in different types of tissues and organisms. Depending on the origin of the autofluorescence, its intensity can provide insights on the physiological state of an organism. Fungal…
Does autoimmune vitiligo protect against COVID‐19 disease? Open
The SARS‐CoV‐2 pandemic has evolved to a global health problem with a dramatic morbidity and mortality rate impacting our daily life and those of many patients. While there is evidence that some diseases are associated with an increased ri…
Alemtuzumab‐induced Alopecia areata – a case report and systematic literature review of adverse events associated with Alemtuzumab Open
Summary Alemtuzumab is currently approved for the treatment of active relapsing‐remitting multiple sclerosis (RRMS). Despite the efficacy of this therapy several side effects in the skin have been noted during or after infusion including v…
Supplementary Material for: Expression of the α7 Nicotinic Acetylcholine Receptor is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis Open
Medicine
Targeting the α7 nicotinic acetylcholine receptor–A novel road towards the future treatment of skin diseases Open
Nicotinic acetylcholine receptors (nAChRs) are members of the superfamily of neurotransmitter‐gated ion channels. The natural ligand for nAChRs is the endogenous neurotransmitter acetylcholine. Among the nAChRs is the α7nAChR. It is not on…
Alemtuzumab‐induced halo naevus‐like hypopigmentation – new insights into secondary skin autoimmunity in response to an immune cell‐depleting antibody Open
We describe a 33‐year‐old male patient who developed hypopigmentation around his melanocytic nevi with disappearance of the nevi in August 2018. In June 2016 he had been diagnosed with highly active RRMS and treated with alemtuzumab in Sep…
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma Open
Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in proce…
Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT‐1 melanoma cells Open
Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells; therefore, search for factors regulating this pathway are strongly desired. Herein, we investigated the effects of melatonin, a ubiquitous physiological…