Christian M. Matter
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View article: Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial
Intake of high-intensity statin after acute myocardial infarction assessed by direct drug concentration measurement: association with LDL-C response and coronary plaque modifications in the PACMAN-AMI trial Open
Background In real-world settings, adherence to preventive cardiovascular medications is often suboptimal. However, in clinical trials, adherence is crucial for ensuring the validity and generalizability of study results, and their clinica…
View article: Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes
Educational level, clinical outcomes and quality of care in a Swiss cohort of patients with acute coronary syndromes Open
Background Despite universal coverage, inequities persist in acute coronary syndrome (ACS) care. This study examines how educational levels impact the quality and outcomes of health care. Methods A cohort of ACS patients hospitalized in fi…
View article: Inflammation and Fibrosis Markers Predict Adverse Outcomes in Arrhythmogenic Cardiomyopathy: An Integrated Multiomics Study
Inflammation and Fibrosis Markers Predict Adverse Outcomes in Arrhythmogenic Cardiomyopathy: An Integrated Multiomics Study Open
Background Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder characterized by fibrofatty replacement of the heart muscle, often resulting in ventricular arrhythmias and heart failure. Predicting the disease course and outcome is ch…
View article: NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice
NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice Open
High-dose NR supplementation in mice did not decrease but increase both aortic plaque lesions and systemic inflammation. These effects may be mediated by increased CD38 expression in macrophages, with NAD+ metabolism shifted from sirtuins …
View article: Microcirculatory Resistance After Primary Percutaneous Coronary Intervention Predicts Residual Myocardial Damage and Scar Formation
Microcirculatory Resistance After Primary Percutaneous Coronary Intervention Predicts Residual Myocardial Damage and Scar Formation Open
Background Coronary microvascular dysfunction has been associated with adverse cardiovascular events following acute myocardial infarction. This study evaluates the role of the angiography‐derived index of microcirculatory resistance (angi…
View article: Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland
Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland Open
Objectives To assess the association between the intensity of statin therapy and the level of physical activity in patients 1 year after an acute coronary syndrome (ACS). Design Prospective cohort study from the Special Program University …
View article: NAD<sup>+</sup> boosting increases atherosclerotic plaques and inflammation in <i>Apoe</i> knockout mice
NAD<sup>+</sup> boosting increases atherosclerotic plaques and inflammation in <i>Apoe</i> knockout mice Open
Background and aims: NAD+ (nicotinamide adenine dinucleotide) is a cosubstrate of the sirtuins (SIRT) that are activated upon caloric restriction. Supplementing NAD+ precursors such as nicotinamide riboside (NR) has been reported to extend…
View article: 2D echocardiography video to 3D heart shape reconstruction for clinical application
2D echocardiography video to 3D heart shape reconstruction for clinical application Open
Transthoracic Echocardiography (TTE) is a crucial tool for assessing cardiac morphology and function quickly and non-invasively without ionising radiation. However, the examination is subject to intra- and inter-user variability and record…
View article: The Gut–Heart Axis: Effects of Intestinal Microbiome Modulation on Cardiovascular Disease—Ready for Therapeutic Interventions?
The Gut–Heart Axis: Effects of Intestinal Microbiome Modulation on Cardiovascular Disease—Ready for Therapeutic Interventions? Open
Recent reports demonstrate an association between distinct bacteria or bacteria-derived metabolites originating from the gut microbiome and the onset or progression of cardiovascular disease (CVD). This raises the opportunity to modulate t…
View article: Health-related quality of life and long-term incidence of major adverse events in patients with acute coronary syndromes
Health-related quality of life and long-term incidence of major adverse events in patients with acute coronary syndromes Open
Background Assessing health-related quality of life (HRQoL) in patients with acute coronary syndromes (ACS) could provide insight into predicting major adverse cardiovascular events (MACE) and all-cause death. Purpose To investigate the as…
View article: Targeting BRD4-HK2 reverses the meta-inflammatory shift in perivascular adipose tissue and rescues cardiometabolic vascular dysfunction
Targeting BRD4-HK2 reverses the meta-inflammatory shift in perivascular adipose tissue and rescues cardiometabolic vascular dysfunction Open
Background/Introduction Reducing vascular inflammation is crucial to halt and reverse cardiometabolic damage. BRD4, an epigenetic pan-inflammatory activator whose inhibition has shown promising results in cancer, may play an important role…
View article: Association between achieved cholesterol levels and the risk of major adverse cardiovascular events after acute coronary syndromes
Association between achieved cholesterol levels and the risk of major adverse cardiovascular events after acute coronary syndromes Open
Background European guidelines recommend reducing lipid levels to defined targets to lower cardiovascular risk after acute coronary syndromes (ACS). Purpose This study aims to evaluate the association of achieved and reduced lipid levels o…
View article: Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes
Body temperature, systemic inflammation and risk of adverse events in patients with acute coronary syndromes Open
Background Inflammatory processes can trigger acute coronary syndromes (ACS) which may increase core body temperature (BT), a widely available low‐cost marker of systemic inflammation. Herein, we aimed to delineate baseline characteristics…
View article: Acute-on-chronic inflammation in acute myocardial infarction
Acute-on-chronic inflammation in acute myocardial infarction Open
Purpose of review Acute myocardial infarction (AMI) is heralded by chronic inflammation and entails an excessive burst of acute-on-chronic inflammation (AoCI). This review describes the evolution from understanding atherosclerosis as a chr…
View article: Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome
Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome Open
BACKGROUND: Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with an…
View article: Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage
Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage Open
Funding Acknowledgements None. Background ROS and inflammation are major features of diabetic vasculopathy, yet the underlying mechanisms remain elusive. Long non-coding RNAs (lncRNAs) are emerging as important players in the pathogenesis …
View article: Transcriptional regulation of hexokinase 2 by BRD4 drives perivascular adipose tissue meta-inflammation in cardiometabolic disease
Transcriptional regulation of hexokinase 2 by BRD4 drives perivascular adipose tissue meta-inflammation in cardiometabolic disease Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Holcim Stiftung SwissLife Stiftung Background/Introduction BRD4 is an epigenetic reader that modulates inflammatory transcriptional programmes implicated…
View article: Transcriptional regulation of Hexokinase-2 by BRD4 drives perivascular adipose tissue meta-inflammation in cardiometabolic disease
Transcriptional regulation of Hexokinase-2 by BRD4 drives perivascular adipose tissue meta-inflammation in cardiometabolic disease Open
Aim: To investigate BRD4-related transcriptional programmes in mouse and human models of cardiometabolic disease. Methods: Small arteries (0.1-0.3 mm) dissected from visceral fat biopsies from healthy subjects (n=16) and patients with obes…
View article: P1132 Fecal incontinence in Inflammatory Bowel Disease (IBD): associated factors and impact on the quality of life of patients in an IBD clinic in Switzerland
P1132 Fecal incontinence in Inflammatory Bowel Disease (IBD): associated factors and impact on the quality of life of patients in an IBD clinic in Switzerland Open
Background Literature on prevalence of fecal incontinence (FI) in inflammatory bowel disease (IBD) and associated factors has not been thoroughly studied. IBD is a chronic disease with high morbidity and significant impact on quality of li…
View article: Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome
Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome Open
Aims To evaluate the risk of alcohol consumption after acute coronary syndromes (ACS). Methods and results A total of 6557 patients hospitalized for ACS at four Swiss centres were followed over 12 months. Weekly alcohol consumption was col…
View article: Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage
Long non-coding RNA PANDA drives diabetic vascular dysfunction by promoting endothelial senescence and oxidative damage Open
Background Accumulation of reactive oxygen species and inflammation are major features of diabetic vasculopathy, yet the underlying mechanisms remain elusive. Long non-coding RNAs (lncRNAs) are emerging as important players in the pathogen…
View article: Therapeutic modulation of epigenetic readers rescues obesity-induced vascular dysfunction: role of endothelium and perivascular adipose tissue
Therapeutic modulation of epigenetic readers rescues obesity-induced vascular dysfunction: role of endothelium and perivascular adipose tissue Open
Background/Introduction Bromodomain and extraterminal proteins (BET), particularly BRD4, are epigenetic readers modulating transcriptional programs implicated in inflammation, cancer and renal disease. Therapeutic potential of BRD4 modulat…
View article: Circulating dipeptidyl peptidase 3 predicts hemodynamic impairment and premature death in acute coronary syndromes: insights from the prospective multicenter SPUM-ACS study
Circulating dipeptidyl peptidase 3 predicts hemodynamic impairment and premature death in acute coronary syndromes: insights from the prospective multicenter SPUM-ACS study Open
Background Dipeptidyl peptidase 3 (DPP3) is mechanistically involved in the degradation of angiotensin II and in the depression of systolic left ventricular function thereby disturbing peripheral blood pressure regulation. Small pilot stud…
View article: Left ventricular stroke volume index outperforms ejection fraction in predicting 1-year mortality in patients with acute heart failure - data from the SwissHeart Failure Network (SHFN)
Left ventricular stroke volume index outperforms ejection fraction in predicting 1-year mortality in patients with acute heart failure - data from the SwissHeart Failure Network (SHFN) Open
Background Left ventricular ejection fraction (LVEF) has prevailed as the gold standard for quantifying LV function in acute heart failure (AHF) for both clinical trials and routine clinical practice. Most landmark studies in AHF stratify …