Marie-José Mercat
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View article: Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development
Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development Open
Gene expression is a dynamic phenotype influenced by tissue-specific regulatory mechanisms, which can modulate expression directly or indirectly through cis or trans factors. Identifying genetic variants in these regulatory regions can imp…
View article: Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development
Single-cell omics reveal distinct gene regulatory dynamics underpinning embryonic and extraembryonic lineage functions during pig blastocyst development Open
Summary The late-stage development of the blastocyst before implantation is a unique feature of ungulates. During this period, the epiblast proliferates and remains pluripotent for several days before gastrulation begins. Simultaneously, e…
View article: Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development
Guiding eQTL mapping and genomic prediction of gene expression in three pig breeds with tissue-specific epigenetic annotations from early development Open
Gene expression is a dynamic phenotype influenced by tissue-specific regulatory mechanisms, which can modulate expression directly or indirectly through cis or trans factors. Identifying genetic variants in these regulatory regions can imp…
View article: Feeding Behaviour in Group-Housed Growing-Finishing Pigs and Its Relationship with Growth and Feed Efficiency
Feeding Behaviour in Group-Housed Growing-Finishing Pigs and Its Relationship with Growth and Feed Efficiency Open
Feed consumption and feeding patterns influence the individual feed efficiency in group-housed livestock species. Using the meal as the unit of feeding behaviour, the main objectives of this research were to identify feeding behaviour (FB)…
View article: Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver
Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver Open
C-reactive protein (CRP) is an evolutionary highly conserved protein. Like humans, CRP acts as a major acute phase protein in pigs. While CRP regulatory mechanisms have been extensively studied in humans, little is known about the molecula…
View article: Assessing the potential of germplasm collections for the management of genetic diversity: the case of the French National Cryobank
Assessing the potential of germplasm collections for the management of genetic diversity: the case of the French National Cryobank Open
Through a combination of selective pressure and genetic drift, there has been a notable erosion of genetic diversity in domesticated animal populations. In response, many countries, including France, have developed gene banks in order to c…
View article: 788. Genetic determinism of boar taint in the French Landrace pig breed
788. Genetic determinism of boar taint in the French Landrace pig breed Open
International audience
View article: 524. Deciphering genetic variants from whole genome affecting duodenum, liver and muscle transcriptomes in pigs
524. Deciphering genetic variants from whole genome affecting duodenum, liver and muscle transcriptomes in pigs Open
International audience
View article: Identification of transcriptional regulatory variants in pig duodenum, liver, and muscle tissues
Identification of transcriptional regulatory variants in pig duodenum, liver, and muscle tissues Open
Background In humans and livestock species, genome-wide association studies (GWAS) have been applied to study the association between variants distributed across the genome and a phenotype of interest. To discover genetic polymorphisms aff…
View article: Discovering genomic regions associated with the phenotypic differentiation of European local pig breeds
Discovering genomic regions associated with the phenotypic differentiation of European local pig breeds Open
Background Intensive selection of modern pig breeds resulted in genetic improvement of productive traits while local pig breeds remained less performant. As they have been bred in extensive systems, they have adapted to specifical environm…
View article: Finishing season and feeding resources influence the quality of products from extensive-system Gascon pigs. Part 1: Carcass traits and quality of fresh loin
Finishing season and feeding resources influence the quality of products from extensive-system Gascon pigs. Part 1: Carcass traits and quality of fresh loin Open
Pig Physiology and Phenotyping Experimental Facilit,doi: 10.15454/1.5573932732039927E12
View article: Runs of homozygosity provide a genome landscape picture of inbreeding and genetic history of European autochthonous and commercial pig breeds
Runs of homozygosity provide a genome landscape picture of inbreeding and genetic history of European autochthonous and commercial pig breeds Open
Summary ROHs are long stretches of DNA homozygous at each polymorphic position. The proportion of genome covered by ROHs and their length are indicators of the level and origin of inbreeding. Frequent common ROHs within the same population…
View article: Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
This study represents, to the best of our knowledge, the first genome-wide map of the genetic control of gene expression in porcine peripheral blood. These results represent an interesting resource for the identification of genetic markers…
View article: Distribution Of Polymorphisms In Major And Candidate Genes For Productive And Domestication-Related Traits In European Local Pig Breeds
Distribution Of Polymorphisms In Major And Candidate Genes For Productive And Domestication-Related Traits In European Local Pig Breeds Open
TREASURE is a multidisciplinary European project focused on the development of activities for the benefit of sustainable pork chains based on European local pigs. One of its main objectives is the genetic characterization of local pig bree…
View article: Additional file 9: Table S7. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 9: Table S7. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Enrichement analysis of cis-genes in ASE analysis by Gorilla. (XLSX 67 kb)
View article: Additional file 15: Table S9. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 15: Table S9. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
QTLs in AnimalQTLdb for pigs (<10Â Mb) harbouring at least one ASE-SNPs. (XLSX 44 kb)
View article: Additional file 14: Table S8. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 14: Table S8. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
QTLs in AnimalQTLdb (<10Â Mb) for pigs harbouring at least one eQTL-SNP. (XLSX 90 kb)
View article: Additional file 1: Table S1. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 1: Table S1. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Associations detected by eGWAS. (XLSX 342 kb)
View article: Additional file 6: Table S4. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 6: Table S4. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Enrichement analysis of associated genes in eGWAS by GOrilla. (XLSX 39 kb)
View article: Additional file 4: Table S3. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 4: Table S3. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
ASE analysis results. (XLSX 126 kb)
View article: Additional file 16: Table S10. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 16: Table S10. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Complete Blood Cell Counts for 195 animals among the 243 eGWAS pigs. (XLSX 14 kb)
View article: Additional file 13: Figure S6. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 13: Figure S6. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Detailed analysis of the association networks centered around eQTL-SNPs ALGA0110383 and MARC0056482. A: Circo plot produced by R package RCirco which maps the two eQTL-SNPs on SSC6 together with their associated genes, according to their g…
View article: Additional file 8: Table S6. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 8: Table S6. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Enrichement analysis of distant-associated genes in eGWAS by GOrilla. (XLSX 21 kb)
View article: Additional file 7: Table S5. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis
Additional file 7: Table S5. of Deciphering the genetic regulation of peripheral blood transcriptome in pigs through expression genome-wide association study and allele-specific expression analysis Open
Enrichement analysis of local-associated genes in eGWAS by GOrilla. (XLSX 28 kb)