Asbjørn Mohr Drewes
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View article: Mild pancreatic fibrosis with preserved exocrine function and increased visceral adipose tissue in m.3243A>G carriers: A magnetic resonance imaging study
Mild pancreatic fibrosis with preserved exocrine function and increased visceral adipose tissue in m.3243A>G carriers: A magnetic resonance imaging study Open
Increased T1 relaxation time and MRE stiffness indicate mild pancreatic fibrosis in m.3243A>G carriers with diabetes, without further evidence of exocrine insufficiency. Visceral fat was increased in m.3243A>G carriers and associated with …
View article: Individual Autonomic Profiles Influence Brain–Heart Connectivity in Tonic Pain
Individual Autonomic Profiles Influence Brain–Heart Connectivity in Tonic Pain Open
These findings highlight the stability of brain-heart coherence during resting and tonic pain in healthy individuals. However, individual autonomic profiles influenced coherence, with enhanced synchronization in the PRD-decreased group and…
View article: Transanal irrigation: Bridging the gap in treatment for chronic constipation and/or faecal incontinence—A systematic review and management guidance
Transanal irrigation: Bridging the gap in treatment for chronic constipation and/or faecal incontinence—A systematic review and management guidance Open
Aim The aims of the study were to: (1) update a systematic review on the efficacy of transanal irrigation (TAI) in patients with chronic constipation (CC) and/or faecal incontinence (FI); (2) provide guidance on the position of TAI in the …
View article: The ProCVT smart-sheet as a new screening tool for cardiovascular autonomic neuropathy: a feasibility study
The ProCVT smart-sheet as a new screening tool for cardiovascular autonomic neuropathy: a feasibility study Open
Introduction Cardiovascular autonomic neuropathy (CAN) is a severe complication of diabetes that impairs the regulation of the cardiovascular system. This can cause hemodynamic instability, arrhythmias, and silent ischemia. Despite its cli…
View article: LeLISA: A New Lectin‑Based Immunoassay for Evaluation of Mucinous and Serous Content in Pancreatic Cystic Neoplasms
LeLISA: A New Lectin‑Based Immunoassay for Evaluation of Mucinous and Serous Content in Pancreatic Cystic Neoplasms Open
View article: Protocol for the FibroCAN study: a randomised controlled trial of finerenone treatment for early-stage cardiovascular autonomic neuropathy in type 2 diabetes
Protocol for the FibroCAN study: a randomised controlled trial of finerenone treatment for early-stage cardiovascular autonomic neuropathy in type 2 diabetes Open
Introduction Cardiovascular autonomic neuropathy (CAN) is a serious, untreatable complication of diabetes that contributes to excess cardiovascular mortality and morbidity. CAN is associated with increased fibrosis and inflammation, possib…
View article: Risk of acute and chronic pancreatitis in patients with psoriasis: A Danish nationwide cohort study
Risk of acute and chronic pancreatitis in patients with psoriasis: A Danish nationwide cohort study Open
View article: Repeated faecal microbiota transplantation for individuals with type 1 diabetes and gastroenteropathy
Repeated faecal microbiota transplantation for individuals with type 1 diabetes and gastroenteropathy Open
View article: Declining incidence of hypoglycaemia in diabetes secondary to chronic pancreatitis: A nationwide cohort study from 2003 to 2022
Declining incidence of hypoglycaemia in diabetes secondary to chronic pancreatitis: A nationwide cohort study from 2003 to 2022 Open
Aims Population‐based studies have consistently shown that individuals with diabetes secondary to chronic pancreatitis (pancreatic diabetes) have a high risk of hypoglycaemia. We aimed to investigate whether this risk has declined over rec…
View article: Effect of Intradermal Morphine on Histaminergic and Non‐Histaminergic Itch: A Randomised, Single‐Blinded, Human Study
Effect of Intradermal Morphine on Histaminergic and Non‐Histaminergic Itch: A Randomised, Single‐Blinded, Human Study Open
Itch can be a side‐effect of drugs like opioids, with prevalence depending on the route of administration. This study aimed to investigate if morphine (1) induced itch and neurogenic inflammation after intradermal injection and (2) modulat…
View article: Rectal Cancer Pain Score: A prospective cohort validation study across recovery stages
Rectal Cancer Pain Score: A prospective cohort validation study across recovery stages Open
Aim Chronic pain affects approximately 30% of rectal cancer (RC) survivors, significantly impairing their quality of life (QoL). The Rectal Cancer Pain Score (RCPS) was developed to evaluate chronic pain in RC patients. While its psychomet…
View article: Increased Glycemic Variability in Patients With Chronic Pancreatitis and Diabetes Compared to Type 2 Diabetes
Increased Glycemic Variability in Patients With Chronic Pancreatitis and Diabetes Compared to Type 2 Diabetes Open
Background: Glycemic variability in diabetes secondary to pancreatic diseases (pancreatic diabetes) remains unclear. We compared glycemic control and variability in patients with pancreatic diabetes and a matched group of individuals with …
View article: LeLISA: A New Lectin-Based Immunoassay for Evaluation of Mucinous and Serous Content in Pancreatic Cystic Neoplasms
LeLISA: A New Lectin-Based Immunoassay for Evaluation of Mucinous and Serous Content in Pancreatic Cystic Neoplasms Open
View article: Prolonged Gastrointestinal Transit Times and Dysmotility in m. <scp>3243A</scp> >G Mitochondrial Disease
Prolonged Gastrointestinal Transit Times and Dysmotility in m. <span>3243A</span> >G Mitochondrial Disease Open
Background Gastrointestinal (GI) symptoms are frequently reported from carriers of the pathogenic mitochondrial DNA variant m.3243A>G, causing decreased mitochondrial adenosine triphosphate (ATP) production. ATP deficiency may adversely af…
View article: Unravelling the heterogeneity of diabetes in chronic pancreatitis: Alpha and beta cell dysfunction and association with glycaemic control
Unravelling the heterogeneity of diabetes in chronic pancreatitis: Alpha and beta cell dysfunction and association with glycaemic control Open
Aims Diabetes in patients with chronic pancreatitis is a heterogeneous condition with some patients presenting with pre‐existing diabetes and others developing diabetes after pancreatitis onset. We aimed to characterise beta and alpha cell…
View article: Deep-learning based automated pancreas segmentation on CT scans of chronic pancreatitis patients
Deep-learning based automated pancreas segmentation on CT scans of chronic pancreatitis patients Open
The AI model demonstrated high accuracy and robustness in pancreas segmentation of both CP patients and healthy subjects, and across diverse sites and scanners, suggesting its potential for clinical application.
View article: Panenteric Transit Times and Contractile Activity in Diabetic Gastroenteropathy
Panenteric Transit Times and Contractile Activity in Diabetic Gastroenteropathy Open
Gastrointestinal transit times, as well as antral and colonic contractile activity, differed between individuals with diabetic gastroenteropathy and controls. The overall gastric contraction frequency was associated with symptom severity.
View article: Diagnostic yield of second-line aetiological workup in patients with presumed idiopathic acute pancreatitis: a retrospective cohort study
Diagnostic yield of second-line aetiological workup in patients with presumed idiopathic acute pancreatitis: a retrospective cohort study Open
A second-line aetiological workup can identify the aetiology in 25% of patients with presumed IAP. The most frequent aetiologies are biliary pancreatitis and pancreatitis with a genetic mutation.
View article: Gastrointestinal Transit Time Assessed Using a <scp>CT</scp>‐Based Radiopaque Marker Method in Patients With Acute Pancreatitis During Methylnaltrexone Treatment
Gastrointestinal Transit Time Assessed Using a <span>CT</span>‐Based Radiopaque Marker Method in Patients With Acute Pancreatitis During Methylnaltrexone Treatment Open
Introduction Dysmotility is common in acute pancreatitis (AP) and may be evaluated using radiopaque markers and imaging. We present a simple CT‐based approach, which was employed in hospitalized patients with AP. Methods This was a seconda…
View article: Efficacy and safety of continuous glucose monitoring on glycaemic control in patients with chronic pancreatitis and insulin‐treated diabetes: A randomised, open‐label, crossover trial
Efficacy and safety of continuous glucose monitoring on glycaemic control in patients with chronic pancreatitis and insulin‐treated diabetes: A randomised, open‐label, crossover trial Open
Aims Continuous glucose monitoring (CGM) improves glycaemic control and reduces hypoglycaemia in type 1 and 2 diabetes, but its role in managing diabetes in chronic pancreatitis is unknown. We aimed to investigate the effect of CGM compare…
View article: Tocilizumab for Painful Chronic Pancreatitis (TOPAC trial): Protocol for a phase 2 randomized, placebo-controlled, double-blind, investigator-initiated trial
Tocilizumab for Painful Chronic Pancreatitis (TOPAC trial): Protocol for a phase 2 randomized, placebo-controlled, double-blind, investigator-initiated trial Open
This placebo-controlled clinical trial aims to study the potential clinical benefits of blocking IL-6 signalling in painful CP.
View article: A cross-cultural study translating and validating the COMPAT-SF pain questionnaire in Telugu, Bengali and Hindi
A cross-cultural study translating and validating the COMPAT-SF pain questionnaire in Telugu, Bengali and Hindi Open
Background and Objectives Chronic pancreatitis (CP) is a fibroinflammatory disease causing functional injury. Abdominal pain is the predominant symptom negatively impacting the quality of life. The Comprehensive Pain Assessment Tool (COMPA…
View article: Diabetic gastroenteropathy: a pan-alimentary complication
Diabetic gastroenteropathy: a pan-alimentary complication Open
View article: Increased Early Post‐Discharge Mortality in Patients With Acute Pancreatitis
Increased Early Post‐Discharge Mortality in Patients With Acute Pancreatitis Open
Background Emerging evidence suggests that individuals who recover from acute pancreatitis may face a significant risk of mortality during the early post‐discharge period. Despite these concerns, comprehensive population‐based studies on t…
View article: Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence
Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence Open
Objectives High-resolution anorectal manometry (HRAM) is the established investigation in faecal incontinence (FI). However, provocative tests (functional lumen imaging probe (FLIP) and anal acoustic reflectometry (AAR)) have been proposed…
View article: Sexual dysfunction after colorectal and anal cancer—treatment in nurse‐led sexological clinics
Sexual dysfunction after colorectal and anal cancer—treatment in nurse‐led sexological clinics Open
Aim Sexual dysfunction after colorectal and anal cancer is common but rarely identified and treated, although effective treatment options do exist. Therefore, we recently established nurse‐led clinics for the treatment of sexual dysfunctio…
View article: Chronic pain after colorectal cancer treatment: A population‐based cross‐sectional study
Chronic pain after colorectal cancer treatment: A population‐based cross‐sectional study Open
Aims With the recently validated tool for estimating chronic pain after colorectal cancer surgery, the aims of this study were to calculate the prevalence and to identify predictive risk factors for chronic pain after colorectal cancer tre…
View article: The decline of male sexual activity and function after surgical treatment for rectal cancer
The decline of male sexual activity and function after surgical treatment for rectal cancer Open
Background and purpose: The prevalence of sequelae following rectal cancer (RC) treatment is high. We investigate the prevalence and temporal change in sexual dysfunction among male RC patient, along with their counselling and treatment ne…
View article: European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management
European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management Open
Introduction Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non‐gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well‐structured approach. If the initial investigatio…
View article: Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study
Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study Open
Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. No study has directly compared geographic differences in clinical character…