M. Monica Gramatges
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View article: Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity
Real-world post-relapse survival outcomes in children with Acute Myeloid Leukemia by race and ethnicity Open
Introduction: Non-Hispanic Black (NHB) and Hispanic children with acute myeloid leukemia (AML) have historically had worse overall survival (OS) compared to their non-Hispanic White (NHW) peers. While our prior work demonstrated comparable…
View article: Supplemental Table 4 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Table 4 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Table 4 shows the top SNP-lipid pairs (LRT <0.01 in SJLIFE) identified through linear regression using continuous lipid traits as endpoints.
View article: Supplemental Figure 3 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Figure 3 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Figure 3 shows an overview of the performed analyses and outcomes.
View article: Supplemental Table 2 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Table 2 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Table 2 shows the demographic and treatment characteristics of the discovery and replication cohorts, stratified per dyslipidemia status.
View article: Data from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Data from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Background:Dyslipidemia can occur as a long-term side effect of childhood cancer treatment. The difference in prevalence among children receiving comparable treatment suggests a role for genetic variation. We conducted the first genome-wid…
View article: Supplemental Table 1 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Table 1 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Table 1 depicts the definition and timing of dyslipidemia assessments per cohort.
View article: Supplemental Figure 2 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Figure 2 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Figure 2 shows the QQ plot of the initial discovery analysis.
View article: Supplemental Table 3 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Table 3 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Table 3 shows the multivariable clinical model, performed in the CCSS Original cohort, to determine treatment factors for stratified GWASs.
View article: Supplemental Figure 1 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Supplemental Figure 1 from Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Supplemental Figure 1 shows the flowcharts of the CCSS Original, SJLIFE, CCSS Expansion, and DCCSS-LATER cohorts, indicating included and excluded subjects.
View article: Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia Patients Have Dismal Outcomes Irrespective of Allogeneic Hematopoietic Stem Cell Transplant: A Single-Center Experience
Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia Patients Have Dismal Outcomes Irrespective of Allogeneic Hematopoietic Stem Cell Transplant: A Single-Center Experience Open
Background: Pediatric non-Down Syndrome Acute Megakaryoblastic Leukemia (non-DS-AMKL) is a rare subtype of Acute Myeloid Leukemia (AML) arising from primitive megakaryocytes and is associated with poor outcomes. Given its high incidence of…
View article: Disparities in Growth Hormone Deficiency Screening, Evaluation, Diagnosis, and Treatment Among At‐Risk Childhood Cancer Survivors in the US
Disparities in Growth Hormone Deficiency Screening, Evaluation, Diagnosis, and Treatment Among At‐Risk Childhood Cancer Survivors in the US Open
Background Minoritized childhood cancer survivors (CCS) may encounter barriers to timely late effects surveillance. We aimed to evaluate clinical and demographic differences in the likelihood of, and timing to, growth hormone deficiency (G…
View article: A multicenter observational cohort study in survivors of Down Syndrome-associated acute leukemia (ALTE22C1): a report from the Children’s Oncology Group
A multicenter observational cohort study in survivors of Down Syndrome-associated acute leukemia (ALTE22C1): a report from the Children’s Oncology Group Open
Background Down syndrome (DS) is a common genetic disorder resulting from an extra copy of genetic material from all or part of chromosome 21. Individuals with DS have a higher burden of co-occurring structural birth defects, neurocognitiv…
View article: Predictors of long-term follow-up clinic attendance and continued engagement among survivors of cancer in childhood and adolescence
Predictors of long-term follow-up clinic attendance and continued engagement among survivors of cancer in childhood and adolescence Open
Purpose Survivorship care is vital to screen for and manage late effects, yet follow-up remains suboptimal. We examined factors associated with long-term survivor clinic (LTSC) nonattendance, delayed initiation, and disengagement at a larg…
View article: Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts
Genetic Contribution to Treatment-Related Dyslipidemia in Adult Survivors of Childhood Cancer: Findings from the CCSS, SJLIFE, and DCCSS-LATER Cohorts Open
Background: Dyslipidemia can occur as a long-term side effect of childhood cancer treatment. The difference in prevalence among children receiving comparable treatment suggests a role for genetic variation. We conducted the first genome-wi…
View article: An analysis of diagnostic metabolomic profiles associated with hepatotoxicity during childhood ALL induction therapy
An analysis of diagnostic metabolomic profiles associated with hepatotoxicity during childhood ALL induction therapy Open
Hepatotoxicity is a well-documented complication of induction chemotherapy for acute lymphoblastic leukemia (ALL), but our understanding of its biological mechanisms is limited. We identified 314 patients with ALL (aged 1-19 years) treated…
View article: <i>TTN</i> and <i>BAG3</i> in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer
<i>TTN</i> and <i>BAG3</i> in Cancer Therapy–Related Cardiomyopathy Among Long-Term Survivors of Childhood Cancer Open
Importance Cancer therapy–related cardiomyopathy (CCM) is an important concern for childhood cancer survivors. In the general population, rare variants in TTN and BAG3 are associated with an increased risk of familial dilated cardiomyopath…
View article: Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia
Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia Open
Background Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop …
View article: A framework‐based guide for adapting and implementing primary care–based pediatric interventions to the pediatric oncology setting: HPV PROTECT as an exemplar
A framework‐based guide for adapting and implementing primary care–based pediatric interventions to the pediatric oncology setting: HPV PROTECT as an exemplar Open
Pediatric oncology providers can help childhood cancer survivors protect their health by ensuring they receive routine preventive services. Management of these services by survivorship providers is necessary due to patients’ suboptimal rat…
View article: Erratum: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR
Erratum: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR Open
View article: Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR
Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR Open
PURPOSE Although the potential transformative effect of electronic health record (EHR) data on clinical research in adult patient populations has been very extensively discussed, the effect on pediatric oncology research has been limited. …
View article: Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study
Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study Open
Purpose Considering the heightened risk of cancer treatment-related cardiomyopathy and cardiac death in long-term survivors of childhood cancer, we aimed to develop and validate a clinically-applicable risk prediction model for cardiomyopa…
View article: Delayed excretion of high‐dose methotrexate in pediatric acute leukemia correlates with laxative and constipation management
Delayed excretion of high‐dose methotrexate in pediatric acute leukemia correlates with laxative and constipation management Open
Background Delayed excretion of high‐dose methotrexate (HD‐MTX) in pediatric acute lymphoblastic leukemia (ALL) can result in significant morbidity. While methotrexate is primarily renally excreted, HD‐MTX may overwhelm renal excretion and…
View article: Frequency of pathogenic germline variants in pediatric medulloblastoma survivors
Frequency of pathogenic germline variants in pediatric medulloblastoma survivors Open
Background Medulloblastoma is the most common malignant brain tumor in children. Most cases are sporadic, but well characterized germline alterations in APC , ELP1 , GPR161 , PTCH1 , SUFU , and TP53 predispose to medulloblastoma. However, …
View article: Household income and health‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research
Household income and health‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research Open
Objective Examine the influence of household income on health‐related quality of life (HRQOL) among children with newly diagnosed acute myeloid leukemia (AML). Design Secondary analysis of data prospectively collected from pediatric patien…
View article: 1701. <i>Trends in Invasive Candidiasis in Children with Hematologic Malignancies: Increased Risk of Dissemination with Non-albicans Candida</i>
1701. <i>Trends in Invasive Candidiasis in Children with Hematologic Malignancies: Increased Risk of Dissemination with Non-albicans Candida</i> Open
Background Candida species are the most common cause of invasive fungal infections in hospitalized patients. Children with hematological malignancies are at increased risk. The epidemiology of species implicated in invasive candidiasis (IC…
View article: Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia
Racial and ethnic disparities in acuity of presentation among children with newly diagnosed acute leukemia Open
We evaluated disparities in disease burden, organ dysfunction, vital signs, and timing of therapy in children newly presenting with acute leukemia. Among 899 patients with acute leukemia diagnosed at two large children's hospitals, a prior…
View article: Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)
Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN) Open
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (C…
View article: Poverty and health equity in childhood leukemia
Poverty and health equity in childhood leukemia Open
In this issue of Blood, Wadhwa et al describe findings from a Children's Oncology Group (COG) study indicating a 1.9-fold greater hazard of relapse among children undergoing maintenance treatment for acute lymphoblastic leukemia (ALL) and …
View article: Trans-ancestral genetic study of diabetes mellitus risk in survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study
Trans-ancestral genetic study of diabetes mellitus risk in survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study Open
Type 2 diabetes mellitus (T2D) is an established late effect of treatment for childhood cancer. Leveraging detailed cancer treatment and whole-genome sequencing data among survivors of childhood cancer of European (EUR) and African (AFR) g…
View article: The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer
The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer Open
Data-driven basic, translational, and clinical research has resulted in improved outcomes for children, adolescents, and young adults (AYAs) with pediatric cancers. However, challenges in sharing data between institutions, particularly in …