Manuel Morrens
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View article: Margins or mainstream: a cross-sectional study on consensual and non-consensual non-monogamy in the general Belgian adult population
Margins or mainstream: a cross-sectional study on consensual and non-consensual non-monogamy in the general Belgian adult population Open
Non-monogamy refers to a type of relationship wherein sexual and/or romantic exclusivity is not upheld. While scientific research has been increasingly focusing on the prevalence of non-monogamy in Western societies, studies typically suff…
View article: Treating complex PTSD with Schema Therapy, ImRs and EMDR: a review and case study
Treating complex PTSD with Schema Therapy, ImRs and EMDR: a review and case study Open
Introduction: Complex PTSD (CPTSD) often results from prolonged trauma, such as childhood abuse or domestic violence. Cognitive Behavioral Therapy (CBT) and Eye Movement Desensitization and Reprocessing (EMDR) are recommended for tr…
View article: Psychiatric symptoms and syndromes in sarcoidosis: a systematic review and meta-analysis
Psychiatric symptoms and syndromes in sarcoidosis: a systematic review and meta-analysis Open
Introduction Sarcoidosis is often associated with psychiatric symptoms and syndromes (PSS). This systematic review and meta-analysis aimed to summarize available literature on the prevalence of PSS in sarcoidosis, as well as their potentia…
View article: Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination
Dynamic immune dysregulation in severe mental illness: Exaggerated innate and attenuated adaptive immune responses following SARS-CoV-2 vaccination Open
Our findings provide in vivo evidence for exaggerated innate and attenuated adaptive immune responses to vaccination in SMI patients. The study underscores the need for longitudinal, experimental approaches in immunopsychiatry to better ch…
View article: Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review
Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review Open
View article: Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis
Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis Open
Electroconvulsive therapy (ECT) is an effective intervention for severe unipolar and bipolar depression, yet its drawbacks often lead to its underutilization. Accurate prediction of ECT outcomes is crucial for optimizing patient care and i…
View article: TSPO PET BRAIN INFLAMMATION IMAGING: A TRANSDIAGNOSTIC SYSTEMATIC REVIEW AND META-ANALYSIS OF 156 CASE-CONTROL STUDIES
TSPO PET BRAIN INFLAMMATION IMAGING: A TRANSDIAGNOSTIC SYSTEMATIC REVIEW AND META-ANALYSIS OF 156 CASE-CONTROL STUDIES Open
Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a molecular target for PET imaging of inflammatory responses in various CNS disorders, but its usefulness appears to vary greatly across disorders, disease s…
View article: Efficacy of inflammation-based stratification for add-on celecoxib or minocycline in major depressive disorder: Protocol of the INSTA-MD double-blind placebo-controlled randomised clinical trial
Efficacy of inflammation-based stratification for add-on celecoxib or minocycline in major depressive disorder: Protocol of the INSTA-MD double-blind placebo-controlled randomised clinical trial Open
View article: Immune-based Machine learning Prediction of Diagnosis and Illness State in Schizophrenia and Bipolar Disorder
Immune-based Machine learning Prediction of Diagnosis and Illness State in Schizophrenia and Bipolar Disorder Open
This study highlights the potential of using immune-based measures to build predictive classification models in schizophrenia and bipolar disorder, with IL-6, TNF-ɑ, IFN-γ, QUINO and PICO as key candidates. While machine learning models su…
View article: Anti-spike antibody responses to SARS-CoV-2 mRNA vaccines in people with schizophrenia and schizoaffective disorder
Anti-spike antibody responses to SARS-CoV-2 mRNA vaccines in people with schizophrenia and schizoaffective disorder Open
In this cohort study of individuals with SZ and a control group without psychiatric disorders, SZ was associated with lower SARS-CoV-2 anti-spike antibody levels following 2 doses of SARS-CoV-2 mRNA vaccination. This highlights the need fo…
View article: Motor learning and performance in schizophrenia and aging: two different patterns of decline
Motor learning and performance in schizophrenia and aging: two different patterns of decline Open
Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in schizophrenia has never been compared with the waning of motor learning ab…
View article: Case report: Psychosis with catatonia in an adult man: a presentation of neurosarcoidosis
Case report: Psychosis with catatonia in an adult man: a presentation of neurosarcoidosis Open
Introduction Sarcoidosis is a multisystem non-caseous granulomatous disease of unknown origin with predominant lung involvement and a variable clinical course. Although rare, neuropsychiatric manifestations such as confusion, problems in o…
View article: Unveiling Transitions in Disease States: Study of Depressive and Anxiety Symptom Networks over Time
Unveiling Transitions in Disease States: Study of Depressive and Anxiety Symptom Networks over Time Open
Background . Major depressive disorder (MDD) and anxiety disorders (AD) have high degrees of comorbidity and show great overlap in symptoms. The analysis of covarying depressive‐ and anxiety symptoms in longitudinal, sparse data panels has…
View article: High unrecognized SARS-CoV-2 exposure of newly admitted and hospitalized psychiatric patients
High unrecognized SARS-CoV-2 exposure of newly admitted and hospitalized psychiatric patients Open
Our work demonstrated a very high unrecognized exposure to SARS-CoV-2 among newly admitted and hospitalized psychiatric inpatients, which is cause for concern in the context of highly robust evidence of adverse outcomes following COVID-19 …
View article: An exploration of suicidal ideation and attempts, and care use and unmet need among suicide-ideators in a Belgian population study
An exploration of suicidal ideation and attempts, and care use and unmet need among suicide-ideators in a Belgian population study Open
View article: TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies
TSPO PET brain inflammation imaging: A transdiagnostic systematic review and meta-analysis of 156 case-control studies Open
This study is the first overarching transdiagnostic meta-analysis of case-control TSPO PET findings in humans across several brain regions. We observed robust increases in the TSPO signal for specific types of disorders, which were widespr…
View article: The sociodemographic factors associated with suicidal ideation and attempts, and care use and unmet need among suicide-ideators in a Belgian population study
The sociodemographic factors associated with suicidal ideation and attempts, and care use and unmet need among suicide-ideators in a Belgian population study Open
Background Suicidal ideation, or thinking about death and suicide, is common across all layers of society. The aim of this paper is to add to the understanding of suicidal ideation in the general population, as well as help-seeking behavio…
View article: Choice of Outcome Measure Predicts Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder [Letter]
Choice of Outcome Measure Predicts Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder [Letter] Open
View article: Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel: a large-scale, open-label, randomised trial (EULAST)
Efficacy of oral versus long-acting antipsychotic treatment in patients with early-phase schizophrenia in Europe and Israel: a large-scale, open-label, randomised trial (EULAST) Open
View article: The attitude of healthcare providers towards medication self‐management in hospitalized patients diagnosed with schizophrenia or bipolar disorders
The attitude of healthcare providers towards medication self‐management in hospitalized patients diagnosed with schizophrenia or bipolar disorders Open
Background Medication self‐management (MSM) is considered an important aspect of pharmacotherapy and plays an essential role in the treatment of various illnesses. To date, research into the willingness and attitude of psychiatric healthca…
View article: Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder
Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder Open
View article: Cov-N-Psy: Neurobiological underpinnings of long Covid neuropsychological consequences
Cov-N-Psy: Neurobiological underpinnings of long Covid neuropsychological consequences Open
View article: Association between gender ratio and inflammatory biomarkers in major depressive disorder: a systematic review and meta-analysis
Association between gender ratio and inflammatory biomarkers in major depressive disorder: a systematic review and meta-analysis Open
View article: Contributions of age and clinical depression to metacognitive performance
Contributions of age and clinical depression to metacognitive performance Open
View article: Akathisia after chronic usage of synthetic cathinones: A case study
Akathisia after chronic usage of synthetic cathinones: A case study Open
Introduction Synthetic cathinones are a heterogenous group of new psychoactive substances (NPS) with a surging prevalence of use. They are sold under the name of “Bath Salts,” “Legal Highs” or “Research Chemical.” It is a heterogeneous gro…
View article: The psychology of kink: A survey study investigating stigma and psychological mechanisms in BDSM
The psychology of kink: A survey study investigating stigma and psychological mechanisms in BDSM Open
Introduction The past years BDSM (an acronym for bondage and discipline, dominance and submission, and sadism and masochism) has gained a significant amount of attention and popularity in the general population, portraying an inaccurate im…
View article: The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis
The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis Open
Background In psychotic and mood disorders, immune alterations are hypothesized to underlie cognitive symptoms, as they have been associated with elevated blood levels of inflammatory cytokines, kynurenine metabolites, and markers of micro…
View article: Medication Self-Management in Hospitalised Patients with Schizophrenia or Bipolar Disorder: The Perceptions of Patients and Healthcare Providers
Medication Self-Management in Hospitalised Patients with Schizophrenia or Bipolar Disorder: The Perceptions of Patients and Healthcare Providers Open
Aim(s): The aim of the study was to explore perspectives of hospitalised patients with schizophrenia or a bipolar disorder and their healthcare providers on medication self-management. Methods: In a qualitative descriptive design, semi-str…
View article: LC-MS biomarker diagnostics for neuroinflammatory disorders
LC-MS biomarker diagnostics for neuroinflammatory disorders Open
View article: Association between serum lithium level and incidence of COVID-19 infection
Association between serum lithium level and incidence of COVID-19 infection Open
Summary An antiviral effect of lithium has been proposed, but never investigated for coronavirus disease 2019 (COVID-19). Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, we show …