Gabriele Morucci
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View article: Ultrastructural insights into early myoblast differentiation induced by shockwave stimulation
Ultrastructural insights into early myoblast differentiation induced by shockwave stimulation Open
Introduction Extracorporeal shockwave therapy (ESWT) is a non-invasive therapeutic modality that uses high-energy acoustic waves (shockwaves, SW) to restore local homeostasis and stimulate tissue healing and regeneration through mechanotra…
View article: Perception of physical therapists towards cadaver dissection: a qualitative survey study
Perception of physical therapists towards cadaver dissection: a qualitative survey study Open
A deep understanding of gross anatomy is imperative for healthcare professionals for clinical examination, diagnosis, and safe and effective treatment of their patients. In this regard, satisfactory assessment of musculoskeletal disorders …
View article: Long-Term Efficacy of Combined Focused and Radial Extracorporeal Shockwave Therapy for Gluteus Medius Tendon Pathology: A Pilot Study
Long-Term Efficacy of Combined Focused and Radial Extracorporeal Shockwave Therapy for Gluteus Medius Tendon Pathology: A Pilot Study Open
Background: Gluteus medius tendinopathy is amongst the most prevalent lower limb tendinopathies and is now recognized as the primary cause of insidious lateral hip pain. Typically affecting middle-aged women, this condition causes disabili…
View article: Pain-Relieving Effects of Shockwave Therapy for Ledderhose Disease: An Ultrasound-Based Study of an Unusual Bilateral Case
Pain-Relieving Effects of Shockwave Therapy for Ledderhose Disease: An Ultrasound-Based Study of an Unusual Bilateral Case Open
Ledderhose disease (LD, or plantar fibromatosis) is a rare, nodular, hyperproliferative condition affecting the plantar aponeurosis of the foot. At present, several conservative, non-surgical treatments have been documented, although with …
View article: Treatment of delayed union of the forearm with extracorporeal shockwave therapy: a case report and literature review
Treatment of delayed union of the forearm with extracorporeal shockwave therapy: a case report and literature review Open
Compared to other long bones, forearm fractures are particularly challenging due to the high rate of complications. These include malunion, delayed/nonunion, wrist and elbow movement reduction, and pain. Surgical procedure is considered th…
View article: Do the fasciae of the soleus have a role in plantar fasciitis?
Do the fasciae of the soleus have a role in plantar fasciitis? Open
Plantar fasciitis is a chronic, self‐limiting, and painful disabling condition affecting the inferomedial aspect of the heel, usually extending toward the metatarsophalangeal joints. There is compelling evidence for a strong correlation be…
View article: A Projected AR Serious Game for Shoulder Rehabilitation Using Hand-Finger Tracking and Performance Metrics: A Preliminary Study on Healthy Subjects
A Projected AR Serious Game for Shoulder Rehabilitation Using Hand-Finger Tracking and Performance Metrics: A Preliminary Study on Healthy Subjects Open
Research studies show that serious games can increase patient motivation regardless of age or illness and be an affordable and promising solution with respect to conventional physiotherapy. In this paper, we present the latest evolution of…
View article: Morphological and Functional Effects of Ultrasound on Blood–Brain Barrier Transitory Opening: An In Vitro Study on Rat Brain Endothelial Cells
Morphological and Functional Effects of Ultrasound on Blood–Brain Barrier Transitory Opening: An In Vitro Study on Rat Brain Endothelial Cells Open
With the recent advances in medicine, human life expectancy is increasing; however, the extra years of life are not necessarily spent in good health or free from disability, resulting in a significantly higher incidence of age-associated p…
View article: Effects of a 24-Week Exercise Program on Functional Fitness, Oxidative Stress, and Salivary Cortisol Levels in Elderly Subjects
Effects of a 24-Week Exercise Program on Functional Fitness, Oxidative Stress, and Salivary Cortisol Levels in Elderly Subjects Open
Background and Objectives: Aging is a biological and irreversible process characterized by physiological alterations resulting in a progressive decline in biological functions, decreased resistance or adaptability to stress, and increased …
View article: Effectiveness of Decision Support to Treat Complex Regional Pain Syndrome
Effectiveness of Decision Support to Treat Complex Regional Pain Syndrome Open
Background: Complex regional pain syndrome (CRPS) type 1 is a rare but disabling pain condition, usually involving distal extremities such as the wrist, hand, ankle, and foot due to either direct or indirect traumas. CRPS type 1 is charact…
View article: “Sport and Anatomy”: Teaching, Research, and Assistance at the University of Pisa
“Sport and Anatomy”: Teaching, Research, and Assistance at the University of Pisa Open
Introduction: Over the last decades, the university system has experienced huge growth, facing several challenges. Accordingly, the University of Pisa recognizes the value and opportunities deriving from research and fully supports collabo…
View article: Molecular Mechanisms Underlying the Pain-Relieving Effects of Extracorporeal Shock Wave Therapy: A Focus on Fascia Nociceptors
Molecular Mechanisms Underlying the Pain-Relieving Effects of Extracorporeal Shock Wave Therapy: A Focus on Fascia Nociceptors Open
In recent years, extracorporeal shock wave therapy (ESWT) has received increasing attention for its potential beneficial effects on various bone and soft-tissue pathologies, yielding promising outcomes for pain relief and functional recove…
View article: The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model
The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model Open
Cadmium (Cd) is a well-known occupational and environmental pollutant worldwide, and its toxicity is widely recognised. Cd is reported to increase the permeability of the blood–brain barrier (BBB) and to penetrate and accumulate in the bra…
View article: Spreading of Alpha Synuclein from Glioblastoma Cells towards Astrocytes Correlates with Stem-like Properties
Spreading of Alpha Synuclein from Glioblastoma Cells towards Astrocytes Correlates with Stem-like Properties Open
Evidence has been recently provided showing that, in baseline conditions, GBM cells feature high levels of α-syn which are way in excess compared with α-syn levels measured within control astrocytes. These findings are consistent along var…
View article: Occurrence of Total and Proteinase K-Resistant Alpha-Synuclein in Glioblastoma Cells Depends on mTOR Activity
Occurrence of Total and Proteinase K-Resistant Alpha-Synuclein in Glioblastoma Cells Depends on mTOR Activity Open
Alpha-synuclein (α-syn) is a protein considered to be detrimental in a number of degenerative disorders (synucleinopathies) of which α-syn aggregates are considered a pathological hallmark. The clearance of α-syn strongly depends on autoph…
View article: The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease
The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease Open
The gastrointestinal (GI) tract is provided with a peculiar nervous network, known as the enteric nervous system (ENS), which is dedicated to the fine control of digestive functions. This forms a complex network, which includes several typ…
View article: Norepinephrine Protects against Methamphetamine Toxicity through β2-Adrenergic Receptors Promoting LC3 Compartmentalization
Norepinephrine Protects against Methamphetamine Toxicity through β2-Adrenergic Receptors Promoting LC3 Compartmentalization Open
Norepinephrine (NE) neurons and extracellular NE exert some protective effects against a variety of insults, including methamphetamine (Meth)-induced cell damage. The intimate mechanism of protection remains difficult to be analyzed in viv…
View article: Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study
Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study Open
In recent years, alcohol abuse has dramatically grown with deleterious consequence for people’s health and, in turn, for health care costs. It has been demonstrated, in humans and animals, that alcohol intoxication induces neuroinflammatio…
View article: Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier
Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier Open
Cadmium (Cd) is a highly toxic environmental pollutant released from the smelting and refining of metals and cigarette smoking. Oral exposure to cadmium may result in adverse effects on a number of tissues, including the central nervous sy…
View article: Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium
Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium Open
The protective effect of cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, against neuronal toxicity induced by cadmium chloride (CdCl2 10 μM) was investigated in a retinoic acid (RA)-differentiated SH-SY5Y neuroblastom…
View article: Aortic arch branching pattern variation: its incidence on a 20030 cases review
Aortic arch branching pattern variation: its incidence on a 20030 cases review Open
Aim of the study: the main objective of this work was to study the frequency of variation of the aortic arch branching pattern in a wide and varied population. Introduction: Variations in the branching pattern of the aortic arch are clinic…
View article: Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation
Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation Open
Interaction between intestinal epithelial cells (IECs) and the underlying immune systems is critical for maintaining intestinal immune homeostasis and mounting appropriate immune responses. We have previously showed that the T helper type …
View article: Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity
Oxaliplatin-induced blood brain barrier loosening: a new point of view on chemotherapy-induced neurotoxicity Open
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its beneficial effects in tumor reduction, the most prevalent side-effect of oxaliplatin treatment is a chemotherapy-induced neuropathy that frequ…
View article: Cadmium-induced neurotoxicity: still much ado
Cadmium-induced neurotoxicity: still much ado Open
Cadmium (Cd) is a highly toxic heavy metal that accumulates in living system and as such is currently one of the most important occupational and environmental pollutants. Cd reaches into the environment by anthropogenic mobilization and it…
View article: Cadmium-induced neurotoxicity: impairment of the blood brain barrier
Cadmium-induced neurotoxicity: impairment of the blood brain barrier Open
Cadmium (Cd), an ubiquitous heavy metal, known to be accumulated outside of the blood–brain barrier (1) and to cause neurotoxicity, has also been demonstrated to induce an increase in the blood–brain barrier (BBB) permeability (2). Key com…
View article: New therapeutic applications of ultrasounds: a preliminary study
New therapeutic applications of ultrasounds: a preliminary study Open
Ultrasound is well known for its imaging role in medicine. Recently, a new role of non-thermal ultrasound has been investigated concerning the central nervous system. Effectively, ultrasound treatment is able to modulate brain functions in…
View article: Protective effect of selenium and zinc against cadmium toxicity in SHSY-5Y neurons
Protective effect of selenium and zinc against cadmium toxicity in SHSY-5Y neurons Open
Cadmium is a widespread heavy metal environmental toxicant and pollutant. Cadmium toxicity affects many tissues and organs including the central nervous system and cadmium exposure has been related to many neurodegenerative diseases (1). C…
View article: Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study
Zinc protection in cadmium-induced Blood Brain Barrier permeability: a metabolic and morphological in vitro study Open
Cadmium (Cd) is a worldwide occupational and environmental pollutant [1]. Cd toxicity is widely known and studied in many tissues and organs such as testis, kidney, liver, lung and brain [2,3]. On the other hand, zinc (Zn) is a trace eleme…
View article: Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier
Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier Open
Due to its high permeability to blood-brain barrier (BBB), cadmium (Cd) has been regarded as a possible etiological factor for human neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease [1]…