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View article: The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies
The influence of HIV infection on myocardial fibrosis diagnosed by cardiac magnetic resonance imaging in adults: a systematic review and meta-analysis of observation studies Open
Introduction Human immunodeficiency virus (HIV) infection is linked to myocardial fibrosis. Observational studies using cardiac magnetic resonance (CMR) have explored this relationship but scarcity of data synthesis limits our understandin…
View article: Assessment of Workers’ Perception of Occupational Hazards at Nampundwe Mine in Zambia
Assessment of Workers’ Perception of Occupational Hazards at Nampundwe Mine in Zambia Open
Background The extent to which Mineworkers perceive hazards at the workplace is important to avoid Mine accidents and thus prevent damage to health, life, and property. However, Mine accidents have increased despite the large investments i…
View article: Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated <i>Plasmodium falciparum</i> infections
Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated <i>Plasmodium falciparum</i> infections Open
Artemisinin‐based combination therapy (ACT) is the first‐line recommended treatment for uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often based on small studies and need to be confirmed and validated in lar…
View article: Risk factors for household vector abundance using indoor CDC light traps in a high malaria transmission area of Northern Zambia
Risk factors for household vector abundance using indoor CDC light traps in a high malaria transmission area of Northern Zambia Open
Malaria transmission is dependent on the density and distribution of mosquito vectors, but drivers of vector abundance have not been adequately studied across a range of transmission settings. To inform intervention strategies for high-bur…
View article: The use of GPS data loggers to describe the impact of spatio-temporal movement patterns on malaria control in a high-transmission area of northern Zambia
The use of GPS data loggers to describe the impact of spatio-temporal movement patterns on malaria control in a high-transmission area of northern Zambia Open
Background: Human movement is a driver of malaria transmission and has implications for sustainable malaria control. However, little research has been done on the impact of fine-scale movement on malaria transmission and control in high-tr…
View article: The Impact of Household and Community Indoor Residual Spray Coverage with Fludora Fusion in a High Malaria Transmission Setting in Northern Zambia
The Impact of Household and Community Indoor Residual Spray Coverage with Fludora Fusion in a High Malaria Transmission Setting in Northern Zambia Open
Zambia’s National Malaria Elimination Program transitioned to Fludora Fusion in 2019 for annual indoor residual spraying (IRS) in Nchelenge District, an area with holoendemic malaria transmission. Previously, IRS was associated with reduct…
View article: Improving service delivery at primary healthcare facilities for achieving Universal Health Coverage: Examining the effects of insecurity in such facilities in Enugu State, Nigeria
Improving service delivery at primary healthcare facilities for achieving Universal Health Coverage: Examining the effects of insecurity in such facilities in Enugu State, Nigeria Open
Background: Availability of health services at the primary healthcare (PHC) level is crucial to the achievement of Universal Health Coverage (UHC). However, insecurity of PHC facilities inspires unavailability of health services. From pers…
View article: Effectiveness of two doses of Euvichol-plus oral cholera vaccine in response to the 2017/2018 outbreak: a matched case–control study in Lusaka, Zambia
Effectiveness of two doses of Euvichol-plus oral cholera vaccine in response to the 2017/2018 outbreak: a matched case–control study in Lusaka, Zambia Open
Introduction Zambia experienced a major cholera outbreak in 2017–2018, with more than 5905 cases reported countrywide, predominantly from the peri-urban slums of Lusaka city. The WHO recommends the use of oral cholera vaccines (OCVs) toget…
View article: Scientific Findings of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe
Scientific Findings of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe Open
For a decade, the Southern and Central Africa International Center of Excellence for Malaria Research has operated with local partners across study sites in Zambia and Zimbabwe that range from hypo- to holoendemic and vary ecologically and…
View article: Policy Implications of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe
Policy Implications of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe Open
The International Centers of Excellence for Malaria Research (ICEMR) were established by the National Institute of Allergy and Infectious Diseases more than a decade ago to provide multidisciplinary research support to malaria control prog…
View article: Whole Blood Transfusion for Severe Malarial Anemia in a High <i>Plasmodium falciparum</i> Transmission Setting
Whole Blood Transfusion for Severe Malarial Anemia in a High <i>Plasmodium falciparum</i> Transmission Setting Open
Background Severe malaria resulting from Plasmodium falciparum infection is the leading parasitic cause of death in children worldwide, and severe malarial anemia (SMA) is the most common clinical presentation. The evidence in support of c…
View article: Improving the availability of vaccines in primary healthcare facilities in South Africa: is the time right for a system redesign process?
Improving the availability of vaccines in primary healthcare facilities in South Africa: is the time right for a system redesign process? Open
An uninterrupted supply of vaccines at different supply chain levels is a basic component of a functional immunization programme and care service. There can be no progress toward achieving universal health coverage and sustainable developm…
View article: Safety and Efficacy of Intermittent Presumptive Treatment with Sulfadoxine-Pyrimethamine Using Rapid Diagnostic Test Screening and Treatment with Dihydroartemisinin-Piperaquine at the First Antenatal Care Visit (IPTp-SP+): Study Protocol for a Randomized Controlled Trial
Safety and Efficacy of Intermittent Presumptive Treatment with Sulfadoxine-Pyrimethamine Using Rapid Diagnostic Test Screening and Treatment with Dihydroartemisinin-Piperaquine at the First Antenatal Care Visit (IPTp-SP+): Study Protocol for a Randomized Controlled Trial Open
Background : Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organization for the prevention of malaria in pregnancy (MIP)-associated adverse outcomes in high bur…
View article: House Structure Is Associated with Malaria among Febrile Patients in a High-Transmission Region of Zambia
House Structure Is Associated with Malaria among Febrile Patients in a High-Transmission Region of Zambia Open
Since the late nineteenth century, the importance of house structure as a determinant of malaria risk has been recognized. Few studies to date have examined the association of housing and malaria in clinical populations. We conducted a cro…
View article: Improving service delivery at primary healthcare facilities for achieving Universal Health Coverage: Examining the effects of insecurity in such facilities in Enugu State, Nigeria
Improving service delivery at primary healthcare facilities for achieving Universal Health Coverage: Examining the effects of insecurity in such facilities in Enugu State, Nigeria Open
Background: Availability of health services at the primary healthcare (PHC) level is crucial to the achievement of Universal Health Coverage (UHC). However, insecurity of PHC facilities inspires unavailability of health services. From pers…
View article: Additional file 1 of Safety and efficacy of intermittent presumptive treatment with sulfadoxine-pyrimethamine using rapid diagnostic test screening and treatment with dihydroartemisinin-piperaquine at the first antenatal care visit (IPTp-SP+): study protocol for a randomized controlled trial
Additional file 1 of Safety and efficacy of intermittent presumptive treatment with sulfadoxine-pyrimethamine using rapid diagnostic test screening and treatment with dihydroartemisinin-piperaquine at the first antenatal care visit (IPTp-SP+): study protocol for a randomized controlled trial Open
Additional file 1. : Supplementary Table S1. SPIRIT figure
View article: The Impact of Three Years of Targeted Indoor Residual Spraying with Pirimiphos-Methyl on Household Vector Abundance in a High Malaria Transmission Area of Northern Zambia
The Impact of Three Years of Targeted Indoor Residual Spraying with Pirimiphos-Methyl on Household Vector Abundance in a High Malaria Transmission Area of Northern Zambia Open
The global malaria burden has decreased substantially, but gains have been uneven both within and between countries. In Zambia, the malaria burden remains high in northern and eastern regions of the country. To effectively reduce malaria t…
View article: The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC Open
The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, incl…
View article: Characteristics of people brought in dead at the Ndola Teaching Hospital in Zambia between 2012 and 2016
Characteristics of people brought in dead at the Ndola Teaching Hospital in Zambia between 2012 and 2016 Open
Background: Death is the end spectrum of everyone's life. From a policy maker's point of view, the cause of death and the place of death are important variables as they have a bearing on the diagnostic capacity of a health system and the l…
View article: Characteristics of people brought in dead at the Ndola Teaching Hospital in Zambia between 2012 and 2016
Characteristics of people brought in dead at the Ndola Teaching Hospital in Zambia between 2012 and 2016 Open
Background: Death is the end spectrum of everyone's life. From a policy maker's point of view, the cause of death and the place of death are important variables as they have a bearing on the diagnostic capacity of a health system and the l…
View article: High Plasmodium falciparum genetic diversity and temporal stability despite control efforts in high transmission settings along the international border between Zambia and the Democratic Republic of the Congo
High Plasmodium falciparum genetic diversity and temporal stability despite control efforts in high transmission settings along the international border between Zambia and the Democratic Republic of the Congo Open
Background While the utility of parasite genotyping for malaria elimination has been extensively documented in low to moderate transmission settings, it has been less well-characterized in holoendemic regions. High malaria burden settings …
View article: A cross-sectional study of the factors associated with male circumcision status among college youth in Ndola, Zambia, 2016
A cross-sectional study of the factors associated with male circumcision status among college youth in Ndola, Zambia, 2016 Open
Background: New cases of HIV are increasing among young adults in Zambia; yet voluntary medical male circumcision (VMMC) coverage as an HIV prevention measure remains low. Despite having the highest HIV burden in the province, Ndola distri…
View article: The Impact of Antimalarial Resistance on the Genetic Structure of<i>Plasmodium falciparum</i>in the DRC
The Impact of Antimalarial Resistance on the Genetic Structure of<i>Plasmodium falciparum</i>in the DRC Open
The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequenced 2537 Plasmodium falciparum infections, inc…
View article: Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial
Efficacy and safety of artemether–lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial Open
Background HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Artemether–lumefantrine (AL) is the most commonly used ACT for treatment of …
View article: Risk Factors for Household Vector Abundance Using Indoor CDC Light Traps in a High Malaria Transmission Area of Northern Zambia
Risk Factors for Household Vector Abundance Using Indoor CDC Light Traps in a High Malaria Transmission Area of Northern Zambia Open
Malaria transmission is dependent on the density and distribution of mosquito vectors, but drivers of vector abundance have not been adequately studied across a range of transmission settings. To inform intervention strategies for high-bur…
View article: The Impact of 3 Years of Targeted Indoor Residual Spraying With Pirimiphos-Methyl on Malaria Parasite Prevalence in a High-Transmission Area of Northern Zambia
The Impact of 3 Years of Targeted Indoor Residual Spraying With Pirimiphos-Methyl on Malaria Parasite Prevalence in a High-Transmission Area of Northern Zambia Open
Malaria transmission in northern Zambia has increased in the past decade, despite malaria control activities. Evidence-based intervention strategies are needed to effectively reduce malaria transmission. Zambia’s National Malaria Control C…