Muthuvel Jayachandran
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View article: Longitudinal Study of the Vascular Glycocalyx and Urinary Podocyte Markers During Pregnancy
Longitudinal Study of the Vascular Glycocalyx and Urinary Podocyte Markers During Pregnancy Open
Background We aimed to assess the longitudinal changes of glycocalyx, a proteoglycan/glycoprotein layer that lines and protects endothelial cells in normotensive pregnancies (NPs); to correlate glycocalyx parameters with kidney injury mark…
View article: Association between Kidney Stones and CKD
Association between Kidney Stones and CKD Open
Key Points Common kidney stones are unlikely to be an independent and direct cause of CKD in the general population. CKD may protect against kidney stones because of changes in key urinary factors critical for stone formation. Background K…
View article: WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES
WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES Open
An anoctamin 4 (ANO4) mutation was identified in dogs with calcium oxalate (CaOx) stones via GWAS, and the content of ANO4 is decreased in urinary extracellular vesicles of human CaOx stone formers. ANO proteins are Ca2+-activated Clchanne…
View article: Circulating extracellular vesicles of neurovascular origin are elevated in women with severe preeclampsia years after their affected pregnancies
Circulating extracellular vesicles of neurovascular origin are elevated in women with severe preeclampsia years after their affected pregnancies Open
Background Preeclampsia (PE), a pregnancy specific hypertensive disorder, has been associated with elevated risk for strokes, cognitive decline, and smaller brain volumes later in life. As severe PE has been associated with the highest ris…
View article: Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers
Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers Open
Background: Low urine pH and volume are established risk factors for uric acid (UA) stone disease (UASD). Renal tubular epithelial cells exposed to an acidic pH and/or UA crystals can shed extracellular vesicles (EVs) into the tubular flui…
View article: Inflammatory Cells in Nephrectomy Tissue from Patients without and with a History of Urinary Stone Disease
Inflammatory Cells in Nephrectomy Tissue from Patients without and with a History of Urinary Stone Disease Open
Background and objectives Urinary stone disease has been associated with inflammation, but the specific cell interactions that mediate events remain poorly defined. This study compared calcification and inflammatory cell patterns in kidney…
View article: Correction to: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones
Correction to: Specific populations of urinary extracellular vesicles and proteins differentiate type 1 primary hyperoxaluria patients without and with nephrocalcinosis or kidney stones Open
An amendment to this paper has been published and can be accessed via the original article.
View article: Peripheral Markers of Neurovascular Unit Integrity and Amyloid-β in the Brains of Menopausal Women
Peripheral Markers of Neurovascular Unit Integrity and Amyloid-β in the Brains of Menopausal Women Open
Background: The identification of blood-borne biomarkers for the diagnosis and prognosis of Alzheimer’s disease and related dementias is more feasible at the population level than obtaining cerebrospinal fluid or neuroimaging markers. Obje…
View article: Menopausal hormone therapy, blood thrombogenicity, and development of white matter hyperintensities in women of the Kronos Early Estrogen Prevention Study
Menopausal hormone therapy, blood thrombogenicity, and development of white matter hyperintensities in women of the Kronos Early Estrogen Prevention Study Open
Objective: Development of white matter hyperintensities (WMH) in the brain is associated with blood thrombogenicity in recently menopausal women. This study examined the influence of menopausal hormone treatments (MHTs) on this association…
View article: Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls
Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls Open
Randall’s plaque (RP; subepithelial calcification) appears to be an important precursor of kidney stone disease. However, RP cannot be noninvasively detected. The present study investigated candidate biomarkers associated with extracellula…
View article: Risk factors of neurovascular ageing in women
Risk factors of neurovascular ageing in women Open
Biological sex and changes in sex hormones throughout life influence all aspects of health and disease. In women, changes in sex hormonal status reflect ovarian function, pregnancy and the use of exogenous hormonal treatments. Longitudinal…
View article: The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned? Open
Objective: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the prematur…
View article: Changes in carotid artery intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study
Changes in carotid artery intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study Open
Objective: Little is known regarding the progression of preclinical atherosclerosis upon cessation of menopausal hormone therapy (MHT). This study evaluated changes in carotid artery intima-media thickness (CIMT) in a subgroup of participa…
View article: Pregnancy history, coronary artery calcification and bone mineral density in menopausal women
Pregnancy history, coronary artery calcification and bone mineral density in menopausal women Open
Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history…
View article: Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of Preeclampsia
Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of Preeclampsia Open
Cerebrovascular reactivity (CVR) is reduced in patients with cognitive decline. Women with a history of preeclampsia are at increased risk for cognitive decline. This study examined an association between pregnancy history and CVR using a …
View article: Characterization of intravascular cellular activation in relationship to subclinical atherosclerosis in postmenopausal women
Characterization of intravascular cellular activation in relationship to subclinical atherosclerosis in postmenopausal women Open
Interactions among actived intravascular cells and their association with subclinical atherosclerosis differ in women depending upon their pregnancy histories.
View article: Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia
Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia Open
Renal histologic expression of the podocyte-specific protein, nephrin, but not podocin, is reduced in preeclamptic compared with normotensive pregnancies. We hypothesized that renal expression of podocyte-specific proteins would be reflect…
View article: Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1
Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1 Open
Background: Non-invasive biomarkers that detect occult pathology in patients with normal glomerular filtration rate (GFR) and normal urine albumin excretion may help identify patients at risk for chronic kidney diseases. Methods: Two promi…