Explanipedia

Switch-Peptides as Folding Precursors in Self-Assembling Peptides and Amyloid Fibrillogenesis Open

M. S. Camus, Richard Mimna, Adrien W. Schmid, Arunan Chandravarkar, Gabriele Tuchscherer , et al. · 2009

Water‐soluble prodrugs of cyclosporine A with tailored conversion rates Open

Arnaud Hamel, Francis Hubler, M. Mutter · 2005

A novel type of water‐soluble prodrugs of cyclosporine A (CsA) is described, featuring a modular system of an enzyme‐cleavable group, a solubilizing moiety and a chemodegradable spacer attached to the hydroxyl function of (4R)‐4‐[(E)‐2‐but…

Debio-025, a novel non-immunosuppressive cyclosporine analog with potent anti-human immunodeficiency virus type I activity: Pharmacological properties and mode of action Open

Brigitte Rosenwirth, MP de Béthune, RG Ptak, LA Pallansch, CA Stoddart , et al. · 2005

Reference LCBP-ARTICLE-2005-005View record in Web of Science Record created on 2006-02-09, modified on 2016-08-08

Conversion of cyclosporine A prodrugs in human tears vs rabbits tears Open

Frédéric Lallemand, O. Felt-Baeyens, Serge Rudaz, Arnaud Hamel, Francis Hubler , et al. · 2004

The aim of this study was to evaluate the rate and mechanism of conversion of two water-soluble prodrugs of cyclosporine A (CsA) intended for topical delivery to the eye. The new molecules were designed according to the double prodrug conc…

Cyclosporin A prodrugs: design, synthesis and biophysical properties Open

Arnaud Hamel, Francis Hubler, A. Carrupt, Roland M. Wenger, M. Mutter · 2004

The cyclic undecapeptide cyclosporin A (CsA) has a remarkable spectrum of diverse biological activities, including anti‐inflammatory, antifungal, antiparasitic as well as immunosuppressive activities. However, the low water solubility of t…

Contents of Next Issues · Themenvorschau Open

M. Korinth, C. Delonge, B.O. Hütter, J.M. Gilsbach, Y. Dencausse , et al. · 2002

Industrial Forum · Industrieforum Open

M. Korinth, C. Delonge, B.O. Hütter, J.M. Gilsbach, Y. Dencausse , et al. · 2002

Peptidomimetics for bridging structure and function: Pseudo-prolines (Psi Pro) in peptide synthesis, molecular recognition, and drug design Open

Gabriele Tuchscherer, M. Mutter · 2001

ABSTRACTS OF ORAL PRESENTATIONS Open

Dirk T. S. Rijkers, Hefziba T. ten Brink, Nourdin Ghalit, Jan Tois, Rob M. J. Liskamp , et al. · 2001

The right 3D-conformation of a peptide, is essential for its biological activity.Nature has found many elegant ways to reduce the flexibility of peptides/proteins in order to control their folding and shape for increasing affinity as well …

CCDC 147541: Experimental Crystal Structure Determination Open

Stéphane Peluso, Thomas Rückle, Christian H.K. Lehmann, M. Mutter, Cristina Peggion , et al. · 2001

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Extending the concept of template‐assembled synthetic proteins Open

Gabriele Tuchscherer, Daniel Grell, M. Mathieu, M. Mutter · 1999

The creation of native‐like macromolecules in copying nature’s way represents a fascinating challenge in protein chemistry today. In the absence of a detailed knowledge of the complex folding pathway the ultimate goal in protein de novo de…

The subtype 2 of angiotensin II receptors and pressure‐natriuresis in adult rat kidneys Open

K L Liu, Ming Lo, Eric Grouzmann, M. Mutter, J Sassard · 1999

The present work examined the effects of the subtype 2 of angiotensin II (AT 2 ) receptors on the pressure‐natriuresis using a new peptide agonist, and the possible involvement of cyclic guanosine 3′, 5′ monophosphate (cyclic GMP) in these…

Self-assembling functionalized templates in biosensor technology Open

Lukas Scheibler, Pascal Dumy, Dimitrios Stamou, Claus Duschl, Horst Vogel , et al. · 1998

Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist (vol 272, pg 7699, 1997) Open

Eric Grouzmann, Thierry Buclin, Maria Martire, Carla Cannizzaro, B. Dörner , et al. · 1998

Non-natural architectures in protein design: TASP molecules as receptor mimetics Open

M. Mutter, Pascal Dumy, Patrick Garrouste, Christian W. Lehmann, Cristina Peggion , et al. · 1997

Non-natural architectures in protein design and mimicry. Open

M. Mutter, Pascal Dumy, Christian W. Lehmann, Gabriele Tuchscherer · 1997

Additions and Correction to: Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist. (vol 272, pg 7699, 1997) Open

Eric Grouzmann, Thierry Buclin, Maria Martire, Carla Cannizzaro, B. Dörner , et al. · 1997

Non-active architectures in protein design: The zinc finger motif as locked-in tertiary fold Open

Gabriele Tuchscherer, M. Mathieu, R. Jaquet, Ivan M. Lang, Christian W. Lehmann , et al. · 1997

Non-native architectures in protein design and mimicry Open

M. Mutter, Gabriele Tuchscherer · 1997

Template-assisted protein design: Chimeric TASP by chemoselective ligation Open

Stefano E. Cervigni, Pascal Dumy, Pravin T. P. Kaumaya, M. Mathieu, Origène Nyanguile , et al. · 1996

This symposium report discusses the recent progress in template-assisted protein de novo design. A no. of chemoselective ligation methods have been evaluated for use in TASP (TASP = template-assembled synthetic proteins) design. Such proce…

Template assisted protein de novo design Open

G. Tuschscherer, M. Mutter · 1996

Templates in protein de novo design Open

Gabriele Tuchscherer, M. Mutter · 1995

A convenient synthesis of cyclic peptides as regioselectively addressable functionalized templates (RAFT) Open

Pascal Dumy, Ian M. Eggleston, Stefano E. Cervigni, U. Sila, Xicheng Sun , et al. · 1995

Polyethylene glycol bound benzyl- and fluorenyl derivatives as solubilizing side-chain protecting groups in peptide synthesis Open

A. Zier, Declan Ryan, M. Mutter · 1994

Chemical synthesis and functional characterization of melittin-TASP molecules Open

Boopathy Dhanapal, Ulrich Meseth, Michael Pawlak, Gabriele Tuchscherer, Hans J. Vogel , et al. · 1994

A symposium report. The total synthesis of melittin-TASP, T4-(4a26) (TASP = template assembled synthetic proteins) is described together with its structural and ion-channel forming properties in planar lipid bilayers. A voltage-dependent c…

The TASP concept : Mimetics of peptide ligands, protein surfaces and folding units Open

Gabriele Tuchscherer, B. Dömer, U. Sila, B. Kamber, M. Mutter · 1993

Prospects and progress in drug design based on peptides and proteins Open

M. Mutter, B. Dörner, C. Sigel, Rainer Floegel, Catherine Servis , et al. · 1993

Non coded C<sup>α,α</sup>‐disubstituted amino acids Open

Vincenzo Pavone, Benedetto Di Blasio, Angela Lombardi, Ornella Maglio, C. ISERNIAI , et al. · 1993

The crystal and molecular structure of the fully protected dipeptide Boc‐Val‐(S)‐α‐MeSer‐OMe has been determined by X‐ray diffraction techniques. Crystals grown from ethyl acetate/n‐pentane mixtures are tetragonal, space group 14 1 , with …

Total chemical synthesis, characterization, and immunological properties of an MHC class I model using the TASP concept for protein de novo design Open

Gabriele Tuchscherer, Catherine Servis, G Corradin, Udo Blum, J. Rivier , et al. · 1992

The design, total chemical synthesis, and immunological properties of a four‐ α ‐helix bundle template‐assembled synthetic protein (TASP) mimicking some of the structural features of the major histocompatibility complex (MHC) class I is de…

Structural versatility of peptides from C<sup>α,α</sup>‐disubstituted glycines: Preferred conformation of the chiral isovaline residue Open

Kurt Nebel, Eva Altmann, M. Mutter, R. Bardi, A. M. Piazzesi , et al. · 1991

The molecular structures of four protected isovaline‐ (Iva‐) containing peptides to the pentamer level have been determined by x‐ray diffraction. The peptides are t ‐Boc‐Ala‐(S)‐Iva‐Ala‐OMe ( t ‐Boc : tert ‐butyloxycarbonyl; OMe : methoxy)…

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