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View article: Assessing the impact of multidisciplinary team gynecological oncology care in Botswana: A potential model for low‐ and middle‐income countries
Assessing the impact of multidisciplinary team gynecological oncology care in Botswana: A potential model for low‐ and middle‐income countries Open
Background In Botswana, a multidisciplinary team (MDT) clinic was established in 2015 to streamline care for all patients with gynecological malignancies including cervical cancer, Botswana’s leading cause of cancer mortality. Methods Pati…
View article: Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Changes in the CD4:CD8 ratio before and after CRT. Frequency of CD4 and CD8 T-cell subsets by flow cytometry. Box plots overlay individual patient data points for CD4 frequency divided by CD8 frequency (CD4:CD8 ratio) over three longitudin…
View article: Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Correlation of the CD4:CD8 ratio with patient OS. Kaplan–Meier curves show OS probabilities by peripheral CD4:CD8 ratio for the total analyzed cohort and by HIV status. Ratios are designated as those lower than the mean (blue) vs. higher t…
View article: Supplementary Tables 1-5 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Tables 1-5 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Tables 1-5
View article: Supplementary Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 2
View article: Data from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Data from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
The global burden of cervical cancer is highest in low- and middle-income countries. Women living with human immunodeficiency virus (HIV) infection are particularly affected by cervical cancer despite availability and adherence to antiretr…
View article: Supplementary Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 1
View article: Supplementary Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 1
View article: Supplementary Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 4
View article: Table 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Table 1 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Clinical characteristics of study participants with locally advanced cervical cancer
View article: Supplementary Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 2
View article: Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Changes in T-cell cytokine expression before and after CRT by HIV status. A, CD8 T cells and (B) CD4 T cells were stained for four primary effector/cytokine markers (CD107a, IFNγ, TNFα, and IL-2). Box plots overlay individual…
View article: Supplementary Tables 1-5 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Tables 1-5 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Tables 1-5
View article: Supplementary Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 3
View article: Supplementary Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 4 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 4
View article: Supplementary Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Supplementary Figure 3 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Supplementary Figure 3
View article: Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Figure 2 from Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
Changes in T-cell subsets before and after CRT by HIV status. A, CD8 T cells and (B) CD4 T cells were stratified into four major subsets by two additional markers (CCR7 and CD45RA) to identify naïve (CD45RA+CCR7
View article: Impact of the COVID-19 Pandemic on Cervical Cancer Treatment Delays in Botswana
Impact of the COVID-19 Pandemic on Cervical Cancer Treatment Delays in Botswana Open
PURPOSE Although the majority of cervical cancer cases are in sub-Saharan Africa, little is known regarding how the COVID-19 pandemic affected cancer care in this context. Drawing from robust longitudinal data, this study aimed to assess c…
View article: Cervical cancer treatment outcomes and survival in Botswana by human immunodeficiency virus status: <i>Ipabalele</i> study results
Cervical cancer treatment outcomes and survival in Botswana by human immunodeficiency virus status: <i>Ipabalele</i> study results Open
Background Cervical cancer is a leading morbidity/mortality cause, frequently co-occurring with human immunodeficiency virus (HIV) positivity, in Botswana. We examined long-term outcomes for Ipabalele study participants receiving curative …
View article: Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation
Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation Open
The global burden of cervical cancer is highest in low- and middle-income countries. Women living with human immunodeficiency virus (HIV) infection are particularly affected by cervical cancer despite availability and adherence to antiretr…
View article: Longitudinal study on quality of life following cervical cancer treatment in Botswana
Longitudinal study on quality of life following cervical cancer treatment in Botswana Open
Purpose This study longitudinally assessed the quality of life (QoL) in patients who completed chemoradiation (CRT) for cervical cancer in Botswana and compared the QoL for those living with and without HIV infection. Methods Patients with…
View article: Quality of Life Gain Following Treatment Among Breast Cancer Survivors With and Without HIV
Quality of Life Gain Following Treatment Among Breast Cancer Survivors With and Without HIV Open
PURPOSE Women living with HIV (WLWH) experience decreased breast cancer survival. We sought to determine whether WLWH surviving breast cancer also experienced different quality of life (QOL) gain. METHODS Women who enrolled in the Thabatse…
View article: Significance of HIV status in cervical cancer patients receiving curative chemoradiation therapy, definitive radiation alone, or palliative radiation in Botswana
Significance of HIV status in cervical cancer patients receiving curative chemoradiation therapy, definitive radiation alone, or palliative radiation in Botswana Open
BACKGROUND Cervical cancer associated with human papillomavirus has the highest cancer incidence and mortality for women in Botswana because of a high HIV prevalence and limited screening. This study investigates the significance of HIV on…
View article: Efficacy of Induction Chemotherapy in the Treatment of Locally Advanced Cervical Cancer
Efficacy of Induction Chemotherapy in the Treatment of Locally Advanced Cervical Cancer Open
View article: Patterns of care and outcomes for endometrial and ovarian cancers in botswana 2015–2021
Patterns of care and outcomes for endometrial and ovarian cancers in botswana 2015–2021 Open
This study demonstrates that a large proportion of patients with ovarian and endometrial cancer in Botswana are diagnosed at an advanced stage, and many do not receive standard-of-care treatment. Further inquiry is required to characterize…
View article: Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa
Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa Open
View article: EP181/#465 Radiation uptake among patients with breast cancer in Botswana
EP181/#465 Radiation uptake among patients with breast cancer in Botswana Open
Objectives This study aims to determine what proportion of patients with breast cancer in Botswana who were eligible for radiation therapy (RT) initiated treatment. Methods We reviewed patient files from January 2015 to December 2019 from …
View article: EP047/#629 Response to treatment and overall survival of cervical cancer in women with and without HIV in Botswana: ipabalele study U54 CA190158-01
EP047/#629 Response to treatment and overall survival of cervical cancer in women with and without HIV in Botswana: ipabalele study U54 CA190158-01 Open
Objectives This study aimed to characterize factors associated with survival and response to treatment among women with cervical cancer in Botswana. Methods Patients with histologically confirmed cervical cancer were prospectively enrolled…
View article: Stage and outcomes of invasive cervical cancer patients in Botswana: A prospective cohort study from 2013 to 2020
Stage and outcomes of invasive cervical cancer patients in Botswana: A prospective cohort study from 2013 to 2020 Open
View article: Five-year overall survival following chemoradiation therapy for locally advanced cervical carcinoma in women living with and without HIV infection in Botswana
Five-year overall survival following chemoradiation therapy for locally advanced cervical carcinoma in women living with and without HIV infection in Botswana Open