Michael T. Nurmohamed
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View article: 10 Managing lupus and cardiovascular disease
10 Managing lupus and cardiovascular disease Open
View article: Correction: Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort
Correction: Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort Open
View article: Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis
Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis Open
Objective To determine whether baseline CD4 + T helper (Th) cell subset proportions in blood may serve as predictive biomarkers for achieving remission 48 weeks after initiating CTLA-4Ig, anti-tumor necrosis factor (TNF), or anti-interleuk…
View article: Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint
Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint Open
Acylcarnitine accumulation is a characteristic of RA FLS metabolic fingerprint and could be linked to mitochondrial dysfunction. In patients with early RA, acylcarnitine content in serum decreases after successful anti-rheumatic treatment.…
View article: Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort
Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort Open
View article: Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial
Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial Open
Background Rheumatoid arthritis elevates cardiovascular disease risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a regulator of low-density lipoprotein (LDL) metabolism, increases LDL-receptor breakdown in the liver, which elev…
View article: POS0410-HPR GLOBAL AWARENESS AMONG HEALTHCARE PROVIDERS OF EULAR RECOMMENDATIONS ON CARDIOVASCULAR RISK MANAGEMENT IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - A SURVEY STUDY
POS0410-HPR GLOBAL AWARENESS AMONG HEALTHCARE PROVIDERS OF EULAR RECOMMENDATIONS ON CARDIOVASCULAR RISK MANAGEMENT IN PEOPLE WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - A SURVEY STUDY Open
View article: ABS0862 SUPERIOR EFFICACY OF BIOLOGICALS DRIVES HIGHER RETENTION RATE OF FIRST bDMARD IN PATIENTS WITH PSORIATIC ARTHRITIS COMPARED TO AXIAL SPONDYLOARTHRITIS: A REAL-WORLD ANALYSIS
ABS0862 SUPERIOR EFFICACY OF BIOLOGICALS DRIVES HIGHER RETENTION RATE OF FIRST bDMARD IN PATIENTS WITH PSORIATIC ARTHRITIS COMPARED TO AXIAL SPONDYLOARTHRITIS: A REAL-WORLD ANALYSIS Open
View article: Epitopes targeted by autoantibodies in presymptomatic individuals predict early rheumatoid arthritis
Epitopes targeted by autoantibodies in presymptomatic individuals predict early rheumatoid arthritis Open
View article: Transitional and CD21− PD-1+ B cells are associated with remission in early rheumatoid arthritis
Transitional and CD21− PD-1+ B cells are associated with remission in early rheumatoid arthritis Open
Background Early initiation of effective treatment is associated with positive long-term prognosis for patients with rheumatoid arthritis (RA). Currently, there are no biomarkers in clinical use to predict treatment response. A predictor o…
View article: Plasma proteome analysis of rheumatic patients reveals differences in fingerprints based on cardiovascular history: a pilot study
Plasma proteome analysis of rheumatic patients reveals differences in fingerprints based on cardiovascular history: a pilot study Open
View article: Acylcarnitine Enrichment as a Characteristic of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Metabolic Fingerprint
Acylcarnitine Enrichment as a Characteristic of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Metabolic Fingerprint Open
View article: Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study
Impaired coagulation parameters in early RA are restored by effective antirheumatic therapy: a prospective pilot study Open
Objectives To assess the effect of treatment on haemostatic parameters in patients with early rheumatoid arthritis (RA). Methods Patients with newly diagnosed RA started methotrexate and were randomised to additional conventional treatment…
View article: Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis
Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis Open
Objective The objective of this study was to determine if baseline adiponectin, leptin, and resistin levels are associated with response to antirheumatic treatment in early rheumatoid arthritis (RA). Methods This study included 341 partici…
View article: Circulating Baseline <scp>CXCR3</scp><sup>+</sup>Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis
Circulating Baseline <span>CXCR3</span><sup>+</sup>Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis Open
Objective The high prevalence of osteoporosis in rheumatoid arthritis (RA) is due to inflammation that stimulates differentiation of osteoclasts, a process involving circulating monocytes and T cell–derived factors. The aim of this study w…
View article: Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritis: data from a randomised controlled trial Open
View article: Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data Open
View article: Patient-perspective and feasibility of home finger-prick testing to complement and facilitate large-scale research in rheumatology
Patient-perspective and feasibility of home finger-prick testing to complement and facilitate large-scale research in rheumatology Open
Background During the COVID-19 pandemic, we developed a digital research platform to longitudinally investigate COVID-19-related outcomes in patients with rheumatic diseases and healthy controls. We used home finger-prick testing in order …
View article: Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: a NORD-STAR study
Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: a NORD-STAR study Open
Objective This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response to conventional and biological antirheumatic treatment in early rheumatoid …
View article: Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis Open
Background Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoids, encompassing pr…
View article: Lipid profile and NT-proBNP changes from pre-clinical to established rheumatoid arthritis: A 12 years follow-up explorative study
Lipid profile and NT-proBNP changes from pre-clinical to established rheumatoid arthritis: A 12 years follow-up explorative study Open
Changes in the lipid profile and NT-proBNP in RA patients seem to be related to inflammation, with changes reflecting an increase in CVD risk occurring along with rises in CRP levels. These changes seem to already be present at diagnosis, …
View article: Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients
Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients Open
Background and aims Rheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα). Currently, there are no biomarkers to predict therapy respon…
View article: Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated
Cardiovascular disease risk in patients with inflammatory arthritis nowadays still substantially elevated Open
Objectives This study aims to assess current cardiovascular disease risk and prevalence of risk factors in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (SpA). Methods 2050 consecutive patie…
View article: Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritis: results from the EuroSpA Research Collaboration Network
Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritis: results from the EuroSpA Research Collaboration Network Open
Objective Evidence indicates reduced treatment effectiveness of TNFi in women with axial spondyloarthritis (axSpA) compared with men. We aimed to investigate sex differences in treatment response and retention rates over 24 months of follo…
View article: Methotrexate Safety and Efficacy in Combination Therapies in Patients With Early Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial
Methotrexate Safety and Efficacy in Combination Therapies in Patients With Early Rheumatoid Arthritis: A Post Hoc Analysis of a Randomized Controlled Trial Open
Objective We investigated methotrexate safety and the influence of dose on efficacy outcomes in combination with three different biologic treatments and with active conventional treatment (ACT) in early rheumatoid arthritis (RA). Methods T…
View article: Oral Versus Subcutaneous Methotrexate in Immune-Mediated Inflammatory Disorders: an Update of the Current Literature
Oral Versus Subcutaneous Methotrexate in Immune-Mediated Inflammatory Disorders: an Update of the Current Literature Open
View article: Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies
Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies Open
Importance There are conflicting data on the association of antidrug antibodies with response to biologic disease–modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA). Objective To analyze the association of antidrug antibo…
View article: Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial Open
View article: Improvement in patient-reported outcomes and work productivity following 3-year ustekinumab or tumour necrosis factor inhibitor treatment in patients with psoriatic arthritis: results from the PsABio real-world study
Improvement in patient-reported outcomes and work productivity following 3-year ustekinumab or tumour necrosis factor inhibitor treatment in patients with psoriatic arthritis: results from the PsABio real-world study Open
View article: Male rheumatoid arthritis patients at substantially higher risk for cardiovascular mortality in comparison to women
Male rheumatoid arthritis patients at substantially higher risk for cardiovascular mortality in comparison to women Open
An increased cardiovascular disease risk is often present in newly diagnosed RA patients, especially male patients, with a large proportion having undiagnosed and untreated hypertension and hypercholesterolemia. Even with structural screen…