Jing Wang
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Efficacy and safety of flumatinib in adults with Ph-positive ALL: a prospective observational study Open
Objective To evaluate the efficacy and safety of flumatinib, a second-generation tyrosine kinase inhibitor (TKI), combined with chemotherapy in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), and t…
Mesenchymal stem cell-derived exosomes ameliorate gentamicin-induced vestibular hair cell injury by regulating the SNARE pathway and enhancing autophagy Open
hucMSC-EXOs delivered via intratympanic injection effectively target vestibular sensory epithelia, significantly suppressing gentamicin-induced balance dysfunction and high-frequency hearing loss, with superior efficacy in partial indicato…
Heterogeneous TP53 mutation subtypes define prognostic classification in Mantle Cell Lymphoma Open
Background: Mantle cell lymphoma (MCL) is a biologically aggressive B-cell malignancy with marked clinical variability. Among its molecular drivers, mutations in the TP53 gene have emerged as pivotal determinants of disease behavior and th…
Delivery of 5-fluorouracil modified MicroRNAs by fucoidan-based magnetic nanoparticles to enhances tumor-localized immunotherapy and chemotherapy Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with an exceedingly low survival rate. It is characterized by a dense fibrotic stroma that impedes drug penetration and limits the efficacy of conventional therapies…
View article: Sotatercept Improves Small Airway Disease and Hyperinflation in Patients with Pulmonary Hypertension
Sotatercept Improves Small Airway Disease and Hyperinflation in Patients with Pulmonary Hypertension Open
Rationale Small airways disease (SAD) and hyperinflation are common in precapillary pulmonary hypertension (PH). Activin signaling plays an important role in airway and bronchial function. Objective To determine whether treatment with sota…
RETRACTED: Bioengineered α-Hairpin Peptide TKH with GKG Linker: A LLPS-Mediated Biomimetic Mineralization System for Intrafibrillar Remineralization and Deep Dentin Tubule Occlusion Open
The authors have requested that this preprint be removed from Research Square.
Unveiling Gastrointestinal Involvement in Hypopituitarism: Clinical Features and Treatment Approaches Open
Background Hypopituitarism, characterized by the deficiency of one or more pituitary hormones, can lead to diverse gastrointestinal (GI) manifestations that are often under‐recognized, particularly in elderly patients. These symptoms, rang…
Safety and clinical efficacy of immune checkpoint inhibitors in pediatric hepatocellular carcinoma: a case report and review of the literature Open
Background Pediatric hepatocellular carcinoma (HCC) is rare, with surgical resection and liver transplantation as primary treatments. No standard options exist for unresectable/metastatic disease. Although immune checkpoint inhibitors (ICI…
Diagnostic Classification of Mild Cognitive Impairment in Parkinson’s Disease Using Subject-Level Stratified Machine-Learning Analysis Open
Background: The timely identification of mild cognitive impairment (MCI) in Parkinson’s disease (PD) is essential for early intervention and clinical management, yet it remains a challenge in practice. Methods: We conducted an analysis of …
View article: To MRAs treatment or not? evidence from a meta-analysis of randomized controlled trials of different MRAs on cardiovascular health in heart failure
To MRAs treatment or not? evidence from a meta-analysis of randomized controlled trials of different MRAs on cardiovascular health in heart failure Open
Background Mineralocorticoid receptor antagonists (MRAs) are pivotal in heart failure (HF) management. Objectives This study evaluates their impact on adverse cardiovascular events and left ventricular ejection fraction (LVEF) in HF patien…
View article: Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms
Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms Open
Purpose: Intracranial aneurysm (IA) is characterized by localized dilation or ballooning of a blood vessel in the brain with life‐threatening consequences. This study set out to investigate the value of Long noncoding RNA myocardial infarc…
Epigastric pain of unknown origin, esophageal and gastric involvement: a Henoch-Schönlein Purpura case report Open
Henoch-Schönlein Purpura (HSP) is an acute systemic vasculitis that primarily affects the skin, gastrointestinal tract, kidneys and joints. It predominantly occurs in children but can occur at any age. We report a case of 48-year-old male …
LY6E as a new prognostic biomarker of multiple myeloma-related bone disease Open
Osteolytic bone disease, which deteriorates the quality of life, is a prevalent complication of multiple myeloma (MM). In this study, we utilized bioinformatics analysis to identify the differentially expressed genes (DEGs) associated with…
View article: Comparison of clinicopathologic features and prognosis between surgically resected pulmonary large-cell neuroendocrine carcinoma and small-cell lung cancer
Comparison of clinicopathologic features and prognosis between surgically resected pulmonary large-cell neuroendocrine carcinoma and small-cell lung cancer Open
LCNEC and SCLC, as well as their subtypes, have distinct clinical features and survival outcomes. SCLC exhibited more malignant biological behavior and was associated with a worse prognosis compared to LCNEC. Postoperative chemotherapy is …
A Survey of Circuit Foundation Model: Foundation AI Models for VLSI Circuit Design and EDA Open
Artificial intelligence (AI)-driven electronic design automation (EDA) techniques have been extensively explored for VLSI circuit design applications. Most recently, foundation AI models for circuits have emerged as a new technology trend.…
Clinical outcomes and therapeutic modalities in older Chinese patients with MCL: a multi-center real-world retrospective study Open
ECOG ≥ 2, high MIPI score, and absence of maintenance therapy were associated with poorer survival outcomes for older Chinese MCL patients. Maintenance therapy and BTKi-containing regimens have been shown to increase the survival rate of o…
Correlation Between Meckel’s Cave Size and lohexol Dosage in Percutaneous Microballoon Compression for Trigeminal Neuralgia of Aged Patients Open
BACKGROUND: Percutaneous microballoon compression (PMC) is a safe and effective method (1) for treating trigeminal neuralgia (TN). Though many surgeons have carried out this kind of surgery, practitioners who lack sufficient surgical exper…
View article: WGCNA and ferroptosis genes in OSCC: unraveling prognostic biomarkers and therapeutic targets
WGCNA and ferroptosis genes in OSCC: unraveling prognostic biomarkers and therapeutic targets Open
Our study presents a novel prognostic model for OSCC patients based on ferroptosis-related genes, which not only predicts survival but also identifies potential therapeutic targets. The model's predictive accuracy and clinical relevance we…
A Theoretical Approach in Applying High-Frequency Acoustic and Elasticity Microscopy to Assess Cells and Tissues Open
Medical ultrasound is a diagnostic imaging modality used for visualizing internal organs; the frequencies typically used are 2–10 MHz. Scanning acoustic microscopy (SAM) is a form of ultrasound where frequencies typically exceed 50 MHz. In…
View article: Predictors of para-aortic lymph node metastasis based on pathological diagnosis via surgical staging in patients with locally advanced cervical cancer: A multicenter study
Predictors of para-aortic lymph node metastasis based on pathological diagnosis via surgical staging in patients with locally advanced cervical cancer: A multicenter study Open
Para-aortic lymph node (PALN) metastasis of patients with locally advanced cervical cancer (LACC) is associated with multiple risk factors. This study aimed to identify risk factors and develop a predictive model for PALN metastasis based …
A two-stage dual-task learning strategy for early prediction of pathological complete response to neoadjuvant chemotherapy for breast cancer using dynamic contrast-enhanced magnetic resonance images Open
Rationale and Objectives: Early prediction of pathological complete response (pCR) can facilitate personalized treatment for breast cancer patients. To improve prediction accuracy at the early time point of neoadjuvant chemotherapy, we pro…
Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles Open
In this study, we designed a nanoscale platform for sustained amino acid delivery to support transplanted pancreatic islets. The platform features mesoporous silica nanoparticles (MSNPs) loaded with glutamine (G), an essential amino acid r…