Manlio Palumbo
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View article: Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study
Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study Open
All cells secrete extracellular vesicles (EVs) containing nucleic acid cargo, including microRNAs (miRNAs), that regulate the function of receiving cells. G protein-coupled receptors (GPCRs) affect intracellular function via multiple signa…
View article: Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study
Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study Open
All cells secrete extracellular vesicles (EVs) containing nucleic acid cargo, including microRNAs (miRNAs), that regulate the function of receiving cells. G protein-coupled receptors (GPCRs) affect intracellular function via multiple signa…
View article: Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study
Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study Open
3. Abstract All cells secrete extracellular vesicles (EVs) containing nucleic acid cargo, including microRNAs (miRNAs), that regulate the function of receiving cells. G protein-coupled receptors (GPCRs) affect intracellular function via mu…
View article: Selective Ligands for Non-Canonical DNA Structures: Do They Have a Future in Medicinal Chemistry?
Selective Ligands for Non-Canonical DNA Structures: Do They Have a Future in Medicinal Chemistry? Open
Winning the war against cancer represents a major goal currently [...]
View article: Of magic bullets, multiple targets, and artificial intelligence. Are we all set to defeat cancer?
Of magic bullets, multiple targets, and artificial intelligence. Are we all set to defeat cancer? Open
Personalized medicine applied to patients with complex diseases, like cancer, grants a better quality of life and longer survival. However, in most instances it is not curative, due to the onset of two main obstacles represented by undesir…
View article: A Mycobacterial Systems Resource for the Research Community
A Mycobacterial Systems Resource for the Research Community Open
Diseases caused by mycobacterial species result in millions of deaths per year globally, and present a substantial health and economic burden, especially in immunocompromised patients. Difficulties inherent in working with mycobacterial pa…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
Maternal microbiome regulation prevents early allergic
View article: VP66.27: Ultrasound characteristics of pelvic lymphoma: not all pelvic masses are gynecological problems!
VP66.27: Ultrasound characteristics of pelvic lymphoma: not all pelvic masses are gynecological problems! Open
To describe sonographic features of pelvic lymphomas mimicking gynecological tumours. This is a retrospective single centre study. Patients who underwent transvaginal ultrasound followed by tru-cut biopsy of a pelvic mass with histological…
View article: Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules
Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules Open
G-quadruplexes are nucleic acids structures stabilized by physiological concentration of potassium ions. Because low stability G-quadruplexes are hardly detectable by mass spectrometry, we optimized solvent conditions: isopropanol in a tri…
View article: Screening of candidate G-quadruplex ligands for the human <i>c-KIT</i> promotorial region and their effects in multiple <i>in-vitro</i> models
Screening of candidate G-quadruplex ligands for the human <i>c-KIT</i> promotorial region and their effects in multiple <i>in-vitro</i> models Open
Stabilization of G-quadruplex (G4) structures in promoters is a novel promising strategy to regulate gene expression at transcriptional and translational levels. c-KIT proto-oncogene encodes for a tyrosine kinase receptor. It is involved i…
View article: CCDC 1006662: Experimental Crystal Structure Determination
CCDC 1006662: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1006663: Experimental Crystal Structure Determination
CCDC 1006663: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …