M. Paz Clares
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View article: A Mn (II) Quinoline Complex (4QMn) Mitigates Oxidative Damage Induced by Ultraviolet Radiation and Protein Aggregation
A Mn (II) Quinoline Complex (4QMn) Mitigates Oxidative Damage Induced by Ultraviolet Radiation and Protein Aggregation Open
Solar radiation, specifically ultraviolet radiation (UVR), is one of the harmful external factors that affect the integrity of the skin upon sun overexposure. Its detrimental effects include skin aging (photoaging), pigmentation disorders,…
View article: Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self‐ and Metal‐Induced α‐Synuclein Aggregation
Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self‐ and Metal‐Induced α‐Synuclein Aggregation Open
Despite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative syndromes, whose generation involves…
View article: Exo- or endo-1<i>H</i>-pyrazole metal coordination modulated by the polyamine chain length in [1 + 1] condensation azamacrocycles. Binuclear complexes with remarkable SOD activity
Exo- or endo-1<i>H</i>-pyrazole metal coordination modulated by the polyamine chain length in [1 + 1] condensation azamacrocycles. Binuclear complexes with remarkable SOD activity Open
Increasing the polyamine chain length changes the binding mode of pyrazole from exo to endo in Cu 2+ complexes of pyrazolacyclophanes, leading to outstanding SOD activity.
View article: Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice Open
Huntington’s disease (HD) is an inherited neurodegenerative disorder considered a rare disease with a prevalence of 5.7 per 100,000 people. It is caused by an autosomal dominant mutation consisting of expansions of trinucleotide repeats th…
View article: Transition Metals Meet Scorpiand-like Ligands
Transition Metals Meet Scorpiand-like Ligands Open
Scorpiand-like ligands combine the preorganization of the donor atoms of macrocycles and the degrees of freedom of the linear ligands. We prepared the complexes of several of these ligands with transition metal ions and made a crystallogra…
View article: The Bioactivity of Xylene, Pyridine, and Pyrazole Aza Macrocycles against Three Representative Leishmania Species
The Bioactivity of Xylene, Pyridine, and Pyrazole Aza Macrocycles against Three Representative Leishmania Species Open
Due to the urgent need for finding effective and free of secondary effect treatments for every clinical form of Leishmaniasis, a series of synthetic xylene, pyridine and, pyrazole azamacrocycles were tested against three Leishmania species…
View article: Identification of Aryl Polyamines Derivatives as Anti-Trypanosoma cruzi Agents Targeting Iron Superoxide Dismutase
Identification of Aryl Polyamines Derivatives as Anti-Trypanosoma cruzi Agents Targeting Iron Superoxide Dismutase Open
Chagas disease (CD) is a tropical and potentially fatal infection caused by Trypanosoma cruzi. Although CD was limited to Latin America as a silent disease, CD has become widespread as a result of globalization. Currently, 6–8 million peop…
View article: Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease
Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease Open
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder, of the so-called minority diseases, due to its low prevalence. It is caused by an abnormally long track of glutamines (polyQs) in mutant huntingtin (mHtt), whic…
View article: CCDC 2161485: Experimental Crystal Structure Determination
CCDC 2161485: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2161486: Experimental Crystal Structure Determination
CCDC 2161486: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Noncovalent Assembly and Catalytic Activity of Hybrid Materials Based on Pd Complexes Adsorbed on Multiwalled Carbon Nanotubes, Graphene, and Graphene Nanoplatelets
Noncovalent Assembly and Catalytic Activity of Hybrid Materials Based on Pd Complexes Adsorbed on Multiwalled Carbon Nanotubes, Graphene, and Graphene Nanoplatelets Open
Green catalysts with excellent performance in Cu-free Sonogashira coupling reactions can be prepared by the supramolecular decoration of graphene surfaces with Pd(II) complexes. Here we report the synthesis, characterization, and catalytic…
View article: Fluorescent Chemosensors Based on Polyamine Ligands: A Review
Fluorescent Chemosensors Based on Polyamine Ligands: A Review Open
Polyamine ligands are water-soluble receptors that are able to coordinate, depending on their protonation degree, either metal ions, anionic, or neutral species. Furthermore, the presence of fluorescent signaling units allows an immediate …
View article: Heterocyclic Diamines with Leishmanicidal Activity
Heterocyclic Diamines with Leishmanicidal Activity Open
Leishmaniasis is one of the world's most neglected diseases with a worldwide prevalence of 12 million people. There are no effective human vaccines for its prevention, and outdated drugs hamper treatment. Therefore, research aimed at devel…
View article: Comprehensive &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; phenotypic-based screening for the identification of new &lt;em&gt;aza-scorpiand&lt;/em&gt; macrocycles agents against &lt;em&gt;T. cruzi&lt;/em&gt;
Comprehensive <em>in vitro</em> and <em>in vivo</em> phenotypic-based screening for the identification of new <em>aza-scorpiand</em> macrocycles agents against <em>T. cruzi</em> Open
Trypanosoma cruzi, the aetiological agent of Chagas disease, is a genuine parasite with a tremendous genetic diversity and a complex life cycle, causing complicated pathogenesis. The treatment of the disease has been studied by scientists …
View article: CCDC 1994845: Experimental Crystal Structure Determination
CCDC 1994845: Experimental Crystal Structure Determination Open
View article: CCDC 1994846: Experimental Crystal Structure Determination
CCDC 1994846: Experimental Crystal Structure Determination Open
View article: CCDC 1994844: Experimental Crystal Structure Determination
CCDC 1994844: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1994847: Experimental Crystal Structure Determination
CCDC 1994847: Experimental Crystal Structure Determination Open
View article: A Metal-Based Receptor for Selective Coordination and Fluorescent Sensing of Chloride
A Metal-Based Receptor for Selective Coordination and Fluorescent Sensing of Chloride Open
A scorpionate Zn2+ complex, constituted by a macrocyclic pyridinophane core attached to a pendant arm containing a fluorescent pyridyl-oxadiazole-phenyl unit (PyPD), has been shown to selectively recognize chloride anions, giving rise to c…
View article: Strong complexes bearing labile ligands: challenges in catalysis with supported metal complexes
Strong complexes bearing labile ligands: challenges in catalysis with supported metal complexes Open
Oral communication abstract about challenges in heterogeneous catalysis with supported Pd(II) complexes. The focus is on ligand geometry (linear, tripodal, macrocyclic) and the necessity of maintaining activated positions on the metal cent…
View article: CCDC 1990725: Experimental Crystal Structure Determination
CCDC 1990725: Experimental Crystal Structure Determination Open
View article: CCDC 1953930: Experimental Crystal Structure Determination
CCDC 1953930: Experimental Crystal Structure Determination Open
View article: CCDC 1953932: Experimental Crystal Structure Determination
CCDC 1953932: Experimental Crystal Structure Determination Open
View article: CCDC 1953933: Experimental Crystal Structure Determination
CCDC 1953933: Experimental Crystal Structure Determination Open
View article: CCDC 1953929: Experimental Crystal Structure Determination
CCDC 1953929: Experimental Crystal Structure Determination Open
View article: CCDC 1529591: Experimental Crystal Structure Determination
CCDC 1529591: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1952561: Experimental Crystal Structure Determination
CCDC 1952561: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Zn<sup>2+</sup>and Cu<sup>2+</sup>complexes of a fluorescent scorpiand-type oxadiazole azamacrocyclic ligand: crystal structures, solution studies and optical properties
Zn<sup>2+</sup>and Cu<sup>2+</sup>complexes of a fluorescent scorpiand-type oxadiazole azamacrocyclic ligand: crystal structures, solution studies and optical properties Open
This paper reports a new scorpiand-type fluorescent ligand able to sense Zn(ii) in aqueous solution at physiological pH 7.4.
View article: Influence of the chain length and metal : ligand ratio on the self-organization processes of Cu<sup>2+</sup>complexes of [1 + 1] 1<i>H</i>-pyrazole azamacrocycles
Influence of the chain length and metal : ligand ratio on the self-organization processes of Cu<sup>2+</sup>complexes of [1 + 1] 1<i>H</i>-pyrazole azamacrocycles Open
The great versatility of the pyrazole moiety combined with polyamines of different chain lengths gives rise to remarkable coordination features.
View article: CCDC 1912378: Experimental Crystal Structure Determination
CCDC 1912378: Experimental Crystal Structure Determination Open