Donald Peebles
YOU?
Author Swipe
View article: Parvovirus: Conservative management of fetal anemia and hydrops
Parvovirus: Conservative management of fetal anemia and hydrops Open
Following the COVID‐19 pandemic, Northwestern Europe has experienced a marked increase in congenital parvovirus infections. This rise is attributed to social distancing measures which disrupted the usual seasonal variation of parvovirus B1…
View article: Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study
Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study Open
Objective Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early‐onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage.…
View article: Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity
Ascending Vaginal Infection in Mice Induces Preterm Birth and Neonatal Morbidity Open
Preterm birth (PTB; delivery before 37 weeks), the main cause of neonatal death worldwide, can lead to adverse neurodevelopmental outcomes, as well as lung and gut pathology. PTB can be associated with ascending vaginal infection. Ascendin…
View article: Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs
Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs Open
Fetal growth restriction (FGR) is associated with uteroplacental insufficiency, and neurodevelopmental and structural brain deficits in the infant. It is currently untreatable. We hypothesised that treating the maternal uterine artery with…
View article: Measuring proximity to standard planes during fetal brain ultrasound scanning
Measuring proximity to standard planes during fetal brain ultrasound scanning Open
This paper introduces a novel pipeline designed to bring ultrasound (US) plane pose estimation closer to clinical use for more effective navigation to the standard planes (SPs) in the fetal brain. We propose a semi-supervised segmentation …
View article: Ultrasound Plane Pose Regression: Assessing Generalized Pose Coordinates in the Fetal Brain
Ultrasound Plane Pose Regression: Assessing Generalized Pose Coordinates in the Fetal Brain Open
In obstetric ultrasound (US) scanning, the learner's ability to mentally build a three-dimensional (3D) map of the fetus from a two-dimensional (2D) US image represents a significant challenge in skill acquisition. We aim to build a US pla…
View article: Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction
Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction Open
BACKGROUNDSevere, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate pati…
View article: Ascending vaginal infection in mice induces preterm birth and neonatal morbidity
Ascending vaginal infection in mice induces preterm birth and neonatal morbidity Open
Preterm birth (PTB; delivery <37 weeks), the main cause of neonatal death worldwide, can lead to adverse neurodevelopmental outcomes, as well as lung and gut pathology. PTB is commonly associated with ascending vaginal infection. Previousl…
View article: Antenatal detection of large‐for‐gestational‐age fetuses following implementation of the Growth Assessment Protocol: secondary analysis of a randomised control trial
Antenatal detection of large‐for‐gestational‐age fetuses following implementation of the Growth Assessment Protocol: secondary analysis of a randomised control trial Open
Objective To determine whether the Growth Assessment Protocol (GAP) affects the antenatal detection of large for gestational age (LGA) or maternal and perinatal outcomes amongst LGA babies. Design Secondary analysis of a pragmatic open ran…
View article: Management of late‐onset fetal growth restriction: pragmatic approach
Management of late‐onset fetal growth restriction: pragmatic approach Open
Objectives There is limited prospective evidence to guide the management of late‐onset fetal growth restriction (FGR) and its differentiation from small‐for‐gestational age. The aim of this study was to assess prospectively a novel protoco…
View article: Ultrasound and biochemical predictors of pregnancy outcome at diagnosis of early-onset fetal growth restriction
Ultrasound and biochemical predictors of pregnancy outcome at diagnosis of early-onset fetal growth restriction Open
Background Severe early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, preventing accurate patient c…
View article: Ultrasound Plane Pose Regression: Assessing Generalized Pose Coordinates in the Fetal Brain
Ultrasound Plane Pose Regression: Assessing Generalized Pose Coordinates in the Fetal Brain Open
In obstetric ultrasound (US) scanning, the learner's ability to mentally build a three-dimensional (3D) map of the fetus from a two-dimensional (2D) US image represents a significant challenge in skill acquisition. We aim to build a US pla…
View article: Improving antenatal detection of small‐for‐gestational‐age fetus: economic evaluation of Growth Assessment Protocol
Improving antenatal detection of small‐for‐gestational‐age fetus: economic evaluation of Growth Assessment Protocol Open
Objective To determine whether the Growth Assessment Protocol ( GAP ), as implemented in the DESiGN trial, is cost‐effective in terms of antenatal detection of small‐for‐gestational‐age ( SGA ) neonate, when compared with standard care. Me…
View article: Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial
Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial Open
Background Antenatal detection and management of small for gestational age (SGA) is a strategy to reduce stillbirth. Large observational studies provide conflicting results on the effect of the Growth Assessment Protocol (GAP) in relation …
View article: Development of standard definitions and grading for Maternal and Fetal Adverse Event Terminology
Development of standard definitions and grading for Maternal and Fetal Adverse Event Terminology Open
Objective Adverse event (AE) monitoring is central to assessing therapeutic safety. The lack of a comprehensive framework to define and grade maternal and fetal AEs in pregnancy trials severely limits understanding risks in pregnant women.…
View article: Dimensionless squared jerk: An objective differential to assess experienced and novice probe movement in obstetric ultrasound
Dimensionless squared jerk: An objective differential to assess experienced and novice probe movement in obstetric ultrasound Open
Objective Widely accepted, validated and objective measures of ultrasound competency have not been established for clinical practice. Outcomes of training curricula are often based on arbitrary thresholds, such as the number of clinical ca…
View article: VP34.01: Dimensionless jerk: an objective differential to assess experienced and novice ultrasound operators in a clinical setting
VP34.01: Dimensionless jerk: an objective differential to assess experienced and novice ultrasound operators in a clinical setting Open
Ultrasound is a dynamic, real-time imaging modality that is widely used in clinical obstetrics. Widely accepted, validated and objective measures of ultrasound competency have not been established for clinical practice. Simulation has been…
View article: Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency
Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency Open
Severe fetal growth restriction (FGR) affects 1:500 pregnancies, is untreatable and causes serious neonatal morbidity and death. Reduced uterine blood flow (UBF) and lack of bioavailable VEGF due to placental insufficiency is a major cause…
View article: A Systematic Review and Meta-analysis of the Use of High-Fidelity Simulation in Obstetric Ultrasound
A Systematic Review and Meta-analysis of the Use of High-Fidelity Simulation in Obstetric Ultrasound Open
Summary Statement There is little global consensus on how to train, assess, and evaluate skills in obstetric ultrasound. The outcomes of curricula, where present, are often based on the number of clinical cases completed, rather than objec…
View article: Cervical Gene Delivery of the Antimicrobial Peptide, Human β-Defensin (HBD)-3, in a Mouse Model of Ascending Infection-Related Preterm Birth
Cervical Gene Delivery of the Antimicrobial Peptide, Human β-Defensin (HBD)-3, in a Mouse Model of Ascending Infection-Related Preterm Birth Open
Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important com…
View article: EP19.17: Late fetal growth restriction management: impact of an evidence‐based approach
EP19.17: Late fetal growth restriction management: impact of an evidence‐based approach Open
To assess the impact of a novel ultrasound protocol for the management of babies with late fetal growth restriction (FGR) and to compare the outcome if the condition is diagnosed before or after birth. In February 2018, at University Colle…
View article: Predictive value of cervical cytokine, antimicrobial and microflora levels for pre-term birth in high-risk women
Predictive value of cervical cytokine, antimicrobial and microflora levels for pre-term birth in high-risk women Open
Spontaneous preterm birth (sPTB, delivery <37 weeks gestation), accounts for approximately 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infection being one contributing factor. This study aimed to determine …