Milica Perišić Nanut
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View article: Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models
Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models Open
Introduction Glioblastoma (GBM) is a highly invasive brain tumor with limited treatment options and poor prognosis. Natural killer (NK) cells are key effectors of antitumor immunity, capable of eliminating cancer stem-like cells. However, …
View article: Osteoclast-expanded supercharged NK cells perform superior antitumour effector functions
Osteoclast-expanded supercharged NK cells perform superior antitumour effector functions Open
Objective Natural killer (NK) cells are the largest innate lymphocyte subset with potent antitumour and antiviral functions. However, clinical utilisation of human NK cells is hampered due to a lack of reliable methods to augment their ant…
View article: Exposure to specific fungal lectins during adhesion impairs biofilm formation of <i>Listeria</i> on polystyrene
Exposure to specific fungal lectins during adhesion impairs biofilm formation of <i>Listeria</i> on polystyrene Open
Listeria monocytogenes is a pathogenic bacterium that can form biofilms in food processing plants, allowing the bacteria to survive despite the control measures applied. As the surface of the bacteria is covered with versatile polysacchari…
View article: Application model of MCDM for selection of automatic rifle
Application model of MCDM for selection of automatic rifle Open
The paper presents a selection of the best automatic rifle of domestic production. The complexity of the problem is conditioned by the different constructional characteristics of automatic rifles, which is why the application of multi-crit…
View article: Editorial: Lysosomal peptidases in tumor immunity
Editorial: Lysosomal peptidases in tumor immunity Open
EDITORIAL article Front. Immunol., 14 March 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1176736
View article: Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders
Cysteine Cathepsins as Therapeutic Targets in Immune Regulation and Immune Disorders Open
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism.…
View article: Cocaprins, β-Trefoil Fold Inhibitors of Cysteine and Aspartic Proteases from Coprinopsis cinerea
Cocaprins, β-Trefoil Fold Inhibitors of Cysteine and Aspartic Proteases from Coprinopsis cinerea Open
We introduce a new family of fungal protease inhibitors with β-trefoil fold from the mushroom Coprinopsis cinerea, named cocaprins, which inhibit both cysteine and aspartic proteases. Two cocaprin-encoding genes are differentially expresse…
View article: Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration Open
Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular…
View article: Antimicrobial activity of piezoelectric polymer: piezoelectricity as the reason for damaging bacterial membrane
Antimicrobial activity of piezoelectric polymer: piezoelectricity as the reason for damaging bacterial membrane Open
Piezoelectric poly- l -lactide nanotubes mechanically deformed with ultrasound selectively destroy bacterial membranes, exhibiting a contact-based antimicrobial effect.
View article: Human CD4+ T-Cell Clone Expansion Leads to the Expression of the Cysteine Peptidase Inhibitor Cystatin F
Human CD4+ T-Cell Clone Expansion Leads to the Expression of the Cysteine Peptidase Inhibitor Cystatin F Open
The existence of CD4+ cytotoxic T cells (CTLs) at relatively high levels under different pathological conditions in vivo suggests their role in protective and/or pathogenic immune functions. CD4+ CTLs utilize the fundamental cytotoxic effe…
View article: Targeting of fluorescent <i>Lactococcus lactis</i> to colorectal cancer cells through surface display of tumour‐antigen binding proteins
Targeting of fluorescent <i>Lactococcus lactis</i> to colorectal cancer cells through surface display of tumour‐antigen binding proteins Open
Summary Development of targeted treatment for colorectal cancer is crucial to avoid side effects. To harness the possibilities offered by microbiome engineering, we prepared safe multifunctional cancer cell‐targeting bacteria Lactococcus l…
View article: The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function
The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function Open
Cysteine cathepsins are primarily involved in the degradation and recycling of proteins in endo-lysosomal compartments but are also gaining recognition as pivotal proteolytic contributors to various immune functions. Through their extracel…
View article: Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity Open
Cystatin F is a protein inhibitor of cysteine cathepsins, peptidases involved in the activation of the effector molecules of the perforin/granzyme pathway. Cystatin F was previously shown to regulate natural killer cell cytotoxicity. Here,…
View article: The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors
The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors Open
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into humans, causing highly prevalent and severe respiratory diseases, often with fatal outcomes. CoVs are a large group of enveloped, single-stranded, …
View article: Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells
Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells Open
Background Cystatin F is a protein inhibitor of cysteine peptidases, expressed predominantly in immune cells and localised in endosomal/lysosomal compartments. In cytotoxic immune cells cystatin F inhibits both the major pro-granzyme conve…
View article: The Carboxypeptidase Activity of Cathepsin X is not Controlled by Endogenous Inhibitors
The Carboxypeptidase Activity of Cathepsin X is not Controlled by Endogenous Inhibitors Open
Cysteine cathepsins are peptidases with housekeeping functions that play different specific roles in different tissues. Endogenous peptidase inhibitors, such as cystatins and thyropins are the ultimate way of controlling their activity. It…
View article: Cystatin F Affects Natural Killer Cell Cytotoxicity
Cystatin F Affects Natural Killer Cell Cytotoxicity Open
Cystatin F is a cysteine peptidase inhibitor which, unlike other cystatin family members, is targeted to endosomal/lysosomal compartments. It is synthesized as an inactive disulfide-linked dimer which is then converted to an active monomer…
View article: Cystatins, cysteine peptidase inhibitors, as regulators of immune cell cytotoxicity
Cystatins, cysteine peptidase inhibitors, as regulators of immune cell cytotoxicity Open
Cystatins comprise a superfamily of evolutionarily related proteins, present in all living organisms, from protozoa to mammals. They act as inhibitors of cysteine peptidases although they can also function independently of their inhibitory…
View article: Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting
Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting Open
Lectins have been recognized as promising carrier molecules for targeted drug delivery. They specifically bind carbohydrate moieties on cell membranes and trigger cell internalization. Fungal lectin MpL (Macrolepiota procera lectin) does n…
View article: Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit
Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit Open
Infections with shiga toxin-producing bacteria, like enterohemorrhagic Escherichia coli and Shigella dysenteriae, represent a serious medical problem. No specific and effective treatment is available for patients with these infections, cre…