Barbara Obermayer‐Pietsch

Maternal Galectins and Glucose Regulation in Pregnancy: Chronic vs. Acute Metabolic Adaptations Open

Ebba Hamann, Evelyn A. Huhn, Pia Roser, Barbara Obermayer‐Pietsch, Herbert Fluhr , et al. · 2025

Galectins exhibited distinct patterns of association with glucose homeostasis during the second trimester of pregnancy. Gal-3 and gal-9 are associated with chronic conditions such as pre-pregnancy obesity and insulin resistance, whereas ga…

Acute Effects of Whole-Body Electromyostimulation Versus High-Intensity Resistance Training on Markers of Bone Turnover in Young Females—A Randomized Controlled Cross-Over Trial Open

Sarah Stimpfig, Robert Kob, Matthias Kohl, Simon von Stengel, Barbara Obermayer‐Pietsch , et al. · 2025

The present study aimed to determine the acute effects of high-intensity dynamic resistance training (HI-DRT) and whole-body electromyostimulation (WB-EMS) on markers of bone formation and resorption in young healthy women. Using a crossov…

MON-185 PCOS in Adolescent Girls versus Young Women: Similar Distribution of Body Fat, Different Severity of PCOS Phenotype Open

Lourdes Ibáñez, Cristina García-Beltrán, Marianne Andersen, Firdevs Baş, Judit Bassols , et al. · 2025

Disclosure: L. Ibanez: None. C. Garcia-Beltran: None. M. Andersen: None. F. Bas: None. J. Bassols: None. F. Darendeliler: None. F. Fanelli: None. E. Fröhlich-Reiterer: None. A. Gambineri: None. D. Glintborg: None. A. Lopez-Bermejo: None. S…

Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool Open

Eugène McCloskey, Helena Johansson, Enwu Liu, Kristina Åkesson, Fred Anderson , et al. · 2025

A family history of fracture is confirmed as a significant BMD-independent predictor of future fracture risk. While parental hip fracture appears the strongest factor for future hip fracture, a family history of other fractures might be ap…

Body mass index and subsequent fracture risk: a meta-analysis to update FRAX Open

Nicholas C. Harvey, Helena Johansson, Eugène McCloskey, Enwu Liu, Kristina Åkesson , et al. · 2025

The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 co…

Pregnancy shifts endothelial progenitor cell morphology and function: Role of metabolism, pro‐inflammatory cytokines and fetal sex Open

Marie‐Therese Weiser‐Fuchs, Andreas Jantscher, Simone Tischler, Elena Osto, Lusik Balayan , et al. · 2025

Endothelial colony forming cells (ECFCs) are circulating progenitor cells essential for angiogenesis and vascular remodelling in pregnancy. ECFC numbers and outgrowth are often reduced with metabolic diseases and conditions associated with…

Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis: A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement Open

Dalal S. Ali, Aliya Khan, Archibald Morrison, Sotirios Tetradis, Reza Mirza , et al. · 2025

Genetic variation in the INMT gene strongly impacts the production of trimethylsulfonium in humans Open

Olivia Trummer, Carina Maria Laglstorfer, Christoph Haudum, Cornelia Missbrenner, Walter Goessler , et al. · 2025

We previously identified the trimethylsulfonium ion (TMS) in human urine and highlighted its potential as a novel H₂S biomarker but observed significant inter-individual variability in its urinary excretion. In this work we inve…

Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure—A prospective cohort study Open

Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik, David Zach , et al. · 2025

Aims Heart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) and appendicular skeletal muscle index (…

High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial Open

Verena Theiler‐Schwetz, Georg Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer‐Pietsch , et al. · 2025

High-dose glucocorticoid treatment was not effective in restoring adrenal function and leads to adverse effects on glucose metabolism. We therefore do not recommend its use for the treatment of ICI associated hypophysitis, except for compr…

Steroid Profiles and Precursor-to-Product Ratios Are Altered in Pregnant Women with Preeclampsia Open

Olivia Trummer, Christina Stern, Sharmaine Reintar, K Mayer-Pickel, M Cervar-Zivkovic , et al. · 2024

Steroid hormone imbalance is associated with the pathogenesis of preeclampsia. However, affected enzymes of steroid metabolism and gene and protein expression in serum and placenta have not been elucidated yet. We aimed to investigate ster…

CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration Open

Tarek Eissa, Marinus Huber, Barbara Obermayer‐Pietsch, Birgit Linkohr, Annette Peters , et al. · 2024

Molecular analytics increasingly utilize machine learning (ML) for predictive modeling based on data acquired through molecular profiling technologies. However, developing robust models that accurately capture physiological phenotypes is c…

MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics Open

Rubén Gil‐Redondo, Ricardo Conde, Chiara Bruzzone, María Luisa Seco, Maider Bizkarguenaga , et al. · 2024

Background Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the risk of developing cardiometabolic health problems. The specific criteria for diagnosing MetS va…

CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration Open

Tarek Eissa, Marinus Huber, Barbara Obermayer‐Pietsch, Birgit Linkohr, Annette Peters , et al. · 2024

Molecular analytics increasingly utilize machine learning (ML) for predictive modeling based on data acquired through molecular profiling technologies. However, developing robust models that accurately capture physiological phenotypes is c…

No requirement of perioperative glucocorticoid replacement in patients with endogenous Cushing’s syndrome – a pilot study Open

Christian Trummer, Marlene Pandis, Verena Theiler‐Schwetz, Lisa Schmitt, Barbara Obermayer‐Pietsch , et al. · 2024

A perspective on muscle phenotyping in musculoskeletal research Open

Ines Foessl, Cheryl L. Ackert‐Bicknell, Érika Kague, Faidra Laskou, Franz Jakob , et al. · 2024

Serum Expression of miR-23a-3p and miR-424-5p Indicate Specific Polycystic Ovary Syndrome Phenotypes: A Pilot Study Open

Olivia Trummer, Jonas Hoeller, Sharmaine Reintar, Veronika Tandl, Ines Foessl , et al. · 2024

MicroRNAs (miRNAs) are single-stranded, non-coding RNAs that regulate mRNA expression on a post-transcriptional level. Observational studies suggest an association of serum miRNAs and polycystic ovary syndrome (PCOS), a common heterogeneou…

Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction Open

Nicolas Verheyen, Johannes Schmid, Ewald Kolesnik, Nora Schwegel, J. Späth , et al. · 2024

Aims Chronic heart failure is associated with a bone‐catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to a…

Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry Open

Kharis Burns, Benjamin H. Mullin, Loes M E Moolhuijsen, Triin Laisk, Jaakko Tyrmi , et al. · 2024

Background Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are heterogeneous with notable differences between lean and obese women, im…

First clinical evidence that trimethylsulfonium can serve as a biomarker for the production of the signaling molecule hydrogen sulfide Open

Francesca Antonaros, Barbara Obermayer‐Pietsch, Giuseppe Ramacieri, Beatrice Vione, Chiara Locatelli , et al. · 2024

A meta-analysis of previous falls and subsequent fracture risk in cohort studies Open

Liesbeth Vandenput, Helena Johansson, Eugène McCloskey, Enwu Liu, Marian Schini , et al. · 2024

Protocol for preliminary, multicenteric validation of “PoCOsteo device”: A point of care tool for proteomic and genomic study of osteoporosis Open

Farideh Razi, Afshin Ostovar, Noushin Fahimfar, Mahsa M. Amoli, Saeed Ebrahimi Fana , et al. · 2024

One of the goals of the HORIZON 2020 project PoCOsteo was to develop a medical device, which would measure and/or quantify proteomic as well as genomic factors as present in whole blood samples collected through finger prick. After validat…

Physical capacity determines physical and mental health in patients with chronic heart failure - a case control study Open

Stefan Winter, Katharina Eberhard, Ewald Kolesnik, Caterina Colantonio, Andreas Baranyi , et al. · 2023

Background Chronic heart failure (CHF) is associated with reduced quality of life (QoL), but underlying mechanisms are incompletely understood. In this study we aimed to assess determinants of both physical and mental functioning in patien…

Corrigendum to “A time-course investigation of the human urinary excretion of the hydrogen sulfide biomarker trimethylsulfonium” [Environ. Toxicol. Pharmacol. 100 (2023) 104162] Open

Bassam Lajin, Barbara Obermayer‐Pietsch, Renato Somma, Walter Goessler · 2023

OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles. Open

Thaís Rocha, Eka Melson, Roland J. Veen, Lida Abdi, Tara McDonnell , et al. · 2023

Disclosure: T.P. Rocha: None. E. Melson: None. R.J. Veen: None. L. Abdi: None. T. McDonnell: None. V. Tandl: None. J. Hawley: None. L. Wittemans: None. A. Anthony: None. L. Gilligan: None. F. Shaheen: None. P. Kempegowda: None. C.D. Gillet…

PCO-Syndrom in der Adoleszenz – neue Therapiemöglichkeiten Open

Hildegard Jasser‐Nitsche, Elke Fröhlich‐Reiterer, Barbara Obermayer‐Pietsch · 2023

Human Milk Oligosaccharides in Maternal Serum Respond to Oral Glucose Load and Are Associated with Insulin Sensitivity Open

Marie‐Therese Weiser‐Fuchs, Elena Maggauer, Mireille N. M. van Poppel, B Csapó, Gernot Desoyé , et al. · 2023

(1) Background: Pregnancy presents a challenge to maternal glucose homeostasis; suboptimal adaptations can lead to gestational diabetes mellitus (GDM). Human milk oligosaccharides (HMOs) circulate in maternal blood in pregnancy and are alt…

Semiautomated Electrochemical Melting Curve Analysis Device for the Detection of an Osteoporosis Associated Single Nucleotide Polymorphism in Blood Open

Cansu Pinar Yenice, Nassif Chahin, Miriam Jauset‐Rubio, Matthew S. Hall, Phil Biggs , et al. · 2023

The detection of single nucleotide polymorphisms (SNPs) is of increasing importance in many areas including clinical diagnostics, patient stratification for pharmacogenomics, and advanced forensic analysis. In the work reported, we apply a…

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX Open

John А. Kanis, Helena Johansson, Eugène McCloskey, Enwu Liu, Kristina Åkesson , et al. · 2023

Identification of Novel Intronic SNPs in Transporter Genes Associated with Metformin Side Effects Open

Natascha Schweighofer, Moritz Strasser, Anna Obermayer, Olivia Trummer, Harald Sourij , et al. · 2023

Metformin is a widely used and effective medication in type 2 diabetes (T2DM) as well as in polycystic ovary syndrome (PCOS). Single nucleotide polymorphisms (SNPs) contribute to the occurrence of metformin side effects. The aim of the pre…

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