Mark H. Pollack
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View article: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104 Open
Background: This study is the first to formally evaluate in humans the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of RE104, a prodrug of the synthetic psychedelic known as 4-hydroxy-N,N-diisopropyltryptamine or 4-OH-…
View article: Exploring study dropout in drug trials for adults with PTSD: insights from a conventional and individual participant data meta-analysis
Exploring study dropout in drug trials for adults with PTSD: insights from a conventional and individual participant data meta-analysis Open
Background: Dropout rates and factors contributing to dropout in drug and placebo groups in pharmacotherapy trials for posttraumatic stress disorder (PTSD) are not well understood.Objective: This study aimed to examine differences in all-c…
View article: Zuranolone, a Positive Allosteric Modulator of the GABA<sub>A</sub> Receptor: Hypothesized Mechanism of Action in Major Depressive Disorder
Zuranolone, a Positive Allosteric Modulator of the GABA<sub>A</sub> Receptor: Hypothesized Mechanism of Action in Major Depressive Disorder Open
Major depressive disorder (MDD) is a heterogeneous condition characterized by depressed mood and/or loss of interest/pleasure in activities, among other symptoms. Most currently available treatments for depression were developed on the hyp…
View article: Zuranolone, a positive allosteric modulator of the GABAA receptor and a neuroactive steroid: hypothesized mechanism of action in depression
Zuranolone, a positive allosteric modulator of the GABAA receptor and a neuroactive steroid: hypothesized mechanism of action in depression Open
International audience
View article: Protocol for a multi-site randomized controlled trial of a stepped-care intervention for emergency department patients with panic-related anxiety
Protocol for a multi-site randomized controlled trial of a stepped-care intervention for emergency department patients with panic-related anxiety Open
Background Approximately 40% of Emergency Department (ED) patients with chest pain meet diagnostic criteria for panic-related anxiety, but only 1–2% are correctly diagnosed and appropriately managed in the ED. A stepped-care model, which f…
View article: Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms
Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms Open
This study confirms an abnormal intestinal environment is present in subjects with PTSD. This study adds to what is already known by examining the intestinal barrier and evaluating the relationship between intestinal readouts and PTSD symp…
View article: Sleep quality and outcome of exposure therapy in adults with social anxiety disorder
Sleep quality and outcome of exposure therapy in adults with social anxiety disorder Open
We replicated and extended findings indicating that poor sleep quality is associated with poorer exposure therapy outcomes for SAD. Assessing for sleep difficulties before treatment initiation and incorporating sleep interventions into tre…
View article: Impact of intensive treatment programs for posttraumatic stress disorder on suicidal ideation in veterans and service members.
Impact of intensive treatment programs for posttraumatic stress disorder on suicidal ideation in veterans and service members. Open
Intensive treatment programs (ITPs) are treating veterans with posttraumatic stress disorder (PTSD) and suicidal ideation (SI). The reduction of SI is a target to the abatement of suicide risk. This study examined whether ITPs utilizing PT…
View article: Maintenance of treatment gains up to 12-months following a three-week cognitive processing therapy-based intensive PTSD treatment programme for veterans
Maintenance of treatment gains up to 12-months following a three-week cognitive processing therapy-based intensive PTSD treatment programme for veterans Open
Overall maintenance of treatment gains long-term suggests veterans may be able to apply skills acquired during the ITP following treatment. These findings further support the feasibility and effectiveness of intensive, trauma-focused, evid…
View article: Dose Timing of <scp>D</scp>-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder
Dose Timing of <span>D</span>-Cycloserine to Augment Exposure Therapy for Social Anxiety Disorder Open
ClinicalTrials.gov Identifier: NCT02066792.
View article: Examining Insomnia During Intensive Treatment for Veterans with Posttraumatic Stress Disorder: Does it Improve and Does it Predict Treatment Outcomes?
Examining Insomnia During Intensive Treatment for Veterans with Posttraumatic Stress Disorder: Does it Improve and Does it Predict Treatment Outcomes? Open
Previous research has demonstrated that sleep disturbances show little improvement with evidence‐based psychotherapy for posttraumatic stress disorder (PTSD); however, sleep improvements are associated with PTSD treatment outcomes. The goa…
View article: Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone <i>vs</i> placebo for the treatment of patients with post-traumatic stress disorder and insomnia
Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone <i>vs</i> placebo for the treatment of patients with post-traumatic stress disorder and insomnia Open
Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturbance.
View article: The Postencounter Form System: Viewpoint on Efficient Data Collection Within Electronic Health Records
The Postencounter Form System: Viewpoint on Efficient Data Collection Within Electronic Health Records Open
Electronic health records (EHRs) offer opportunities for research and improvements in patient care. However, challenges exist in using data from EHRs due to the volume of information existing within clinical notes, which can be labor inten…
View article: Examining the Impact of Sexual Revictimization in a Sample of Veterans Undergoing Intensive PTSD Treatment
Examining the Impact of Sexual Revictimization in a Sample of Veterans Undergoing Intensive PTSD Treatment Open
Sexual revictimization refers to exposure to more than one incident of rape and is a known risk factor for poor mental health among civilians. This construct has been understudied among veterans. In addition, although individuals who have …
View article: The Postencounter Form System: Viewpoint on Efficient Data Collection Within Electronic Health Records (Preprint)
The Postencounter Form System: Viewpoint on Efficient Data Collection Within Electronic Health Records (Preprint) Open
UNSTRUCTURED Electronic health records (EHRs) offer opportunities for research and improvements in patient care. However, challenges exist in using data from EHRs due to the volume of information existing within clinical notes, which can …
View article: Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder Open
Preclinical and clinical data have shown that D-cycloserine (DCS), a partial agonist at the N-methyl-d-aspartate receptor complex, augments the retention of fear extinction in animals and the therapeutic learning from exposure therapy in h…
View article: Feasibility of a 3-week intensive treatment program for service members and veterans with PTSD.
Feasibility of a 3-week intensive treatment program for service members and veterans with PTSD. Open
The present study demonstrates that ITP formats for PTSD are of interest and acceptable to veterans, and this format allows individuals to receive high doses of evidence-based treatments in a short amount of time. (PsycInfo Database Record…
View article: Collaborative Care for Depression of Adults and Adolescents: Measuring the Effectiveness of Screening and Treatment Uptake
Collaborative Care for Depression of Adults and Adolescents: Measuring the Effectiveness of Screening and Treatment Uptake Open
The intervention shows promise in expanding access to care and reducing disparities. Greater access to psychotherapies and innovative treatment modalities, particularly for adolescents, may improve overall treatment uptake.
View article: A placebo‐controlled pilot study of a wearable morning bright light treatment for probable PTSD
A placebo‐controlled pilot study of a wearable morning bright light treatment for probable PTSD Open
The Re-timer® was well tolerated and the perceived benefit was high, though treatment adherence was only moderate. Those in the active group were more likely to achieve a minimal clinically important change in PTSD and depression symptoms …
View article: 0863 Morning Bright Light Treatment Improves Function and Reduces Pain Sensitivity in Veterans with Chronic Low Back Pain
0863 Morning Bright Light Treatment Improves Function and Reduces Pain Sensitivity in Veterans with Chronic Low Back Pain Open
There is an urgent need to develop readily available and safe non-pharmacological treatments for chronic pain. This is particularly the case for US military veterans, of which ~50% report experiencing chronic pain, most commonly in the bac…