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View article: Magnetic Cationic Liposomes-Based Delivery System Reduces Drug-Induced Cytotoxicity in an In Vitro Model of Hearing Loss
Magnetic Cationic Liposomes-Based Delivery System Reduces Drug-Induced Cytotoxicity in an In Vitro Model of Hearing Loss Open
Hearing loss is a major health burden, often caused by ototoxic drugs such as cisplatin and gentamicin. Effective therapy is limited by the poor penetrability of drugs into inner ear compartments. This study aimed to develop and test magne…
View article: Development of an Innovative Nanosystem Based on Functionalized Albumin and Oxidized Gellan for the Synergistic Delivery of Curcumin and Temozolomide in the Treatment of Brain Cancer
Development of an Innovative Nanosystem Based on Functionalized Albumin and Oxidized Gellan for the Synergistic Delivery of Curcumin and Temozolomide in the Treatment of Brain Cancer Open
Treating brain cancer remains challenging due to the blood–brain barrier (BBB) and the systemic toxicity of chemotherapy. This study focuses on developing human serum albumin (HSA) nanoparticles modified with low-molecular-weight protamine…
View article: Metronidazole-Loaded Chitosan Nanoparticles with Antimicrobial Activity Against Clostridium perfringens
Metronidazole-Loaded Chitosan Nanoparticles with Antimicrobial Activity Against Clostridium perfringens Open
Background/Objectives: Even with improvements in surgical techniques and the application of appropriate antibiotic prophylaxis, wound infections are still major public health problems in low- and middle-income countries. This study propose…
View article: Markedly Enhanced Photoluminescence of Carbon Dots Dispersed in Deuterium Oxide
Markedly Enhanced Photoluminescence of Carbon Dots Dispersed in Deuterium Oxide Open
In this work, we report some surprisingly interesting results in our pursuit to improve the photoluminescent emission of Carbon Dots (CDs) prepared from various precursors. By simply replacing the regular water with deuterium oxide (D2O) a…
View article: Double Peptide-Functionalized Carboxymethyl Chitosan-Coated Liposomes Loaded with Dexamethasone as a Potential Strategy for Active Targeting Drug Delivery
Double Peptide-Functionalized Carboxymethyl Chitosan-Coated Liposomes Loaded with Dexamethasone as a Potential Strategy for Active Targeting Drug Delivery Open
Liposomes are intensively used as nanocarriers for biology, biochemistry, medicine, and in the cosmetics industry and their non-toxic and biocompatible nature makes these vesicles attractive systems for biomedical applications. Moreover, t…
View article: In Vivo Assessment of Healing Potential of Ointments Containing Bee Products, Vegetal Extracts, and Polymers on Skin Lesions
In Vivo Assessment of Healing Potential of Ointments Containing Bee Products, Vegetal Extracts, and Polymers on Skin Lesions Open
Background/Objectives: The present experiment aimed to formulate four ointments that included mixtures of plant extracts (Hippophae rhamnoides, Calendula officinalis, Arctium lappa, and Achillea millefolium), apitherapy products (honey, pr…
View article: Developing and Characterizing a Biocompatible Hydrogel Obtained by Cross-Linking Gelatin with Oxidized Sodium Alginate for Potential Biomedical Applications
Developing and Characterizing a Biocompatible Hydrogel Obtained by Cross-Linking Gelatin with Oxidized Sodium Alginate for Potential Biomedical Applications Open
The main goal of this research was to create biocompatible hydrogels using gelatin and a double cross-linking technique involving both covalent and ionic bonds to immobilize propolis. The covalent bonds were formed through Schiff base cros…
View article: A Natural Carbon Encapsulated in Gellan-Based Hydrogel Particles Designed for Environmental Challenges
A Natural Carbon Encapsulated in Gellan-Based Hydrogel Particles Designed for Environmental Challenges Open
This article reports the obtention of a new gellan-based hydrogel linked with Fe3+ and loaded with a natural micro/nanostructured carbon designed as a contaminant’s removal from wastewater. Hydrogels are known for their water-retaining pro…
View article: Developing and Characterizing a Biocompatible Hydrogel Obtained by Cross-Linking Gelatin with Oxidized Sodium Alginate for Potential Biomedical Applications
Developing and Characterizing a Biocompatible Hydrogel Obtained by Cross-Linking Gelatin with Oxidized Sodium Alginate for Potential Biomedical Applications Open
The main goal of this research is to create biocompatible hydrogels using gelatin and a double cross-linking technique involving both covalent and ionic bonds to immobilize propolis. Covalent bonds are formed through Schiff base cross-link…
View article: Comparative In Vitro Study between Biocompatible Chitosan-Based Magnetic Nanocapsules and Liposome Formulations with Potential Application in Anti-Inflammatory Therapy
Comparative In Vitro Study between Biocompatible Chitosan-Based Magnetic Nanocapsules and Liposome Formulations with Potential Application in Anti-Inflammatory Therapy Open
This study describes the comparison between the interaction of a series of peptide-functionalized chitosan-based nanocapsules and liposomes with two cell lines, i.e., mouse macrophages RAW 264.7 and human endothelial cells EA.hy926. Both t…
View article: Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications
Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications Open
Adding carbonyl groups into the hydrogel matrix improves the stability and biocompatibility of the hydrogels, making them suitable for different biomedical applications. In this review article, we will discuss the use of hydrogels based on…
View article: Albumin-Based Hydrogel Films Covalently Cross-Linked with Oxidized Gellan with Encapsulated Curcumin for Biomedical Applications
Albumin-Based Hydrogel Films Covalently Cross-Linked with Oxidized Gellan with Encapsulated Curcumin for Biomedical Applications Open
Bovine serum albumin (BSA) hydrogels are non-immunogenic, low-cost, biocompatible, and biodegradable. In order to avoid toxic cross-linking agents, gellan was oxidized with NaIO4 to obtain new functional groups like dialdehydes for protein…
View article: DRUG DELIVERY SYSTEMS BASED ON GELLAN DERIVATIVES
DRUG DELIVERY SYSTEMS BASED ON GELLAN DERIVATIVES Open
This paper proposes a review of the literature that reports valuable and interesting results regarding the biomedical applications of gellan and its derivatives. The different types of formulations for which this microbial exopolysaccharid…
View article: Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics
Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics Open
Nanotechnology is the science of creating materials at the nanoscale by using various devices, structures, and systems that are often inspired by nature. Micro- and nanoparticles (MPs, NPs) are examples of such materials that have unique p…
View article: Peptide-Functionalized Magnetic Micro/Nanocapsules Loaded with Dexamethasone for Dual Active Targeted Treatment of Inner Ear Inflammation
Peptide-Functionalized Magnetic Micro/Nanocapsules Loaded with Dexamethasone for Dual Active Targeted Treatment of Inner Ear Inflammation Open
View article: ELECTRO-FENTON PROCESS FOR DIBUTYL PHTHALATE DEGRADATION: TOWARD LANDFILLS LEACHATE TREATMENT
ELECTRO-FENTON PROCESS FOR DIBUTYL PHTHALATE DEGRADATION: TOWARD LANDFILLS LEACHATE TREATMENT Open
View article: Photoluminescence of Argan-Waste-Derived Carbon Nanodots Embedded in Polymer Matrices
Photoluminescence of Argan-Waste-Derived Carbon Nanodots Embedded in Polymer Matrices Open
In this work, photoluminescent (PL) carbon nano dots (CNDs) prepared from argan waste were embedded in highly optical transparent poly(styrene-co-acrylonitrile) (PSA) and cyclo-olefin copolymer (COC) matrices, which were further processed …
View article: Superparamagnetic Hybrid Nanospheres Based on Chitosan Obtained by Double Crosslinking in a Reverse Emulsion for Cancer Treatment
Superparamagnetic Hybrid Nanospheres Based on Chitosan Obtained by Double Crosslinking in a Reverse Emulsion for Cancer Treatment Open
Nowadays, the Magnetically Targeted Drug Delivery System (MTDDS) is among the most attractive and promising strategies for delivering drugs to the target site. The present study aimed to obtain a biopolymer–magnetite–drug nanosystem via a …
View article: Recent Advancements and Strategies for Overcoming the Blood–Brain Barrier Using Albumin-Based Drug Delivery Systems to Treat Brain Cancer, with a Focus on Glioblastoma
Recent Advancements and Strategies for Overcoming the Blood–Brain Barrier Using Albumin-Based Drug Delivery Systems to Treat Brain Cancer, with a Focus on Glioblastoma Open
Glioblastoma multiforme (GBM) is a highly aggressive malignant tumor, and the most prevalent primary malignant tumor affecting the brain and central nervous system. Recent research indicates that the genetic profile of GBM makes it resista…
View article: An Accessible Method to Improve the Stability and Reusability of Porcine Pancreatic α-Amylase via Immobilization in Gellan-Based Hydrogel Particles Obtained by Ionic Cross-Linking with Mg2+ Ions
An Accessible Method to Improve the Stability and Reusability of Porcine Pancreatic α-Amylase via Immobilization in Gellan-Based Hydrogel Particles Obtained by Ionic Cross-Linking with Mg2+ Ions Open
Amylase is an enzyme used to hydrolyze starch in order to obtain different products that are mainly used in the food industry. The results reported in this article refer to the immobilization of α-amylase in gellan hydrogel particles ionic…
View article: Semi-Interpenetrating Polymer Networks Based on Hydroxy-Ethyl Methacrylate and Poly(4-vinylpyridine)/Polybetaines, as Supports for Sorption and Release of Tetracycline
Semi-Interpenetrating Polymer Networks Based on Hydroxy-Ethyl Methacrylate and Poly(4-vinylpyridine)/Polybetaines, as Supports for Sorption and Release of Tetracycline Open
Semi-interpenetrating polymer networks (semi-IPN) represent a type of polymeric material that has gained increasing amount of interest for their potential biomedical application. This study presents the synthesis, characterization and tetr…
View article: Editorial on Special Issue “Pharmaceutical Formulations with Antimicrobial Properties”
Editorial on Special Issue “Pharmaceutical Formulations with Antimicrobial Properties” Open
Even though numerous studies on the systemic administration of antimicrobial drugs can be found in the literature, they still have many shortcomings related to the site-specific drug delivery, unwanted side effects and even potential toxic…
View article: Intense Blue Photo Emissive Carbon Dots Prepared through Pyrolytic Processing of Ligno-Cellulosic Wastes
Intense Blue Photo Emissive Carbon Dots Prepared through Pyrolytic Processing of Ligno-Cellulosic Wastes Open
In this work, Carbon Dots with intense blue photo-luminescent emission were prepared through a pyrolytic processing of forestry ligno-cellulosic waste. The preparation path is simple and straightforward, mainly consisting of drying and fin…
View article: Photoluminescent Polymer Aerogels with R, G and B Emission
Photoluminescent Polymer Aerogels with R, G and B Emission Open
In this work, three new polymer aerogels based on 2-hydroxy ethyl methacrylate (HEMA) complexes with Eu(III), Tb(III) and La(III) are prepared and investigated. The polymer aerogels present strong photoluminescence with emissions located i…
View article: An Interpenetrating Polymer Network Hydrogel Based on Cellulose, Applied to Remove Colorant Traces from the Water Medium: Electrostatic Interactions Analysis
An Interpenetrating Polymer Network Hydrogel Based on Cellulose, Applied to Remove Colorant Traces from the Water Medium: Electrostatic Interactions Analysis Open
The main objective of this work was the removal of eosin Y and green malachite from an aqueous medium by using a cellulose-based biodegradable interpenetrated network (IPN). The IPN was obtained by the sequenced synthesis method. In the fi…
View article: Grafted Microparticles Based on Glycidyl Methacrylate, Hydroxyethyl Methacrylate and Sodium Hyaluronate: Synthesis, Characterization, Adsorption and Release Studies of Metronidazole
Grafted Microparticles Based on Glycidyl Methacrylate, Hydroxyethyl Methacrylate and Sodium Hyaluronate: Synthesis, Characterization, Adsorption and Release Studies of Metronidazole Open
Three types of precursor microparticles based on glycidyl methacrylate, hydroxyethyl methacrylate and one of the following three crosslinking agents (mono-, di- or triethylene glycol dimethacrylate) were prepared using the suspension polym…
View article: Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles Open
The physicochemical properties of "smart" or stimuli-sensitive amphiphilic copolymers can be modeled as a function of their environment. In special, pH-sensitive copolymers have practical applications in the biomedical field as drug delive…
View article: Drug-Loaded Polymeric Micelles Based on Smart Biocompatible Graft Copolymers with Potential Applications for the Treatment of Glaucoma
Drug-Loaded Polymeric Micelles Based on Smart Biocompatible Graft Copolymers with Potential Applications for the Treatment of Glaucoma Open
Glaucoma is the second leading cause of blindness in the world. Despite the fact that many treatments are currently available for eye diseases, the key issue that arises is the administration of drugs for long periods of time and the incre…
View article: Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications
Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications Open
Chitosan (CS) crosslinking has been thoroughly investigated, but the chemical reactions leading to submicronic hydrogel formulations pose problems due to various physical/chemical interactions that limit chitosan processability. The curren…