Prafulla Sabale
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View article: Therapeutic role of isoflavones from traditional medicine in the management of polycystic ovary syndrome
Therapeutic role of isoflavones from traditional medicine in the management of polycystic ovary syndrome Open
Introduction: Polycystic ovary syndrome (PCOS) is a significant public health problem and one of the most common gynaecological and endocrine disorder.This condition affects an estimated 8–13 % of women of reproductive age worldwide. PCOS …
View article: Comparative study of UV spectroscopy, RP-HPLC and HPTLC methods for quantification of antiviral drug lamivudine in tablet formulation
Comparative study of UV spectroscopy, RP-HPLC and HPTLC methods for quantification of antiviral drug lamivudine in tablet formulation Open
Background In the current study, estimation of lamivudine (LMU) by UV spectroscopy, reverse-phase HPLC (RP-HPLC) and HPTLC methods in tablet formulation was developed, and comparative studies between the methods were investigated by analyt…
View article: In-silico design and synthesis of curcumin derivatives with enhanced antibacterial and anti-inflammatory activities
In-silico design and synthesis of curcumin derivatives with enhanced antibacterial and anti-inflammatory activities Open
Since curcumin and curcuminoids include potential functional groups (such as α, β-unsaturated β-diketone, α, β-unsaturated ketone, and β 0-hydroxy-α, β-unsaturated ketone linked with aromatic rings on both sides), they have been the subjec…
View article: Development and Optimization of Proniosomal Formulation of Irbesartan Using a Box–Behnken Design to Enhance Oral Bioavailability: Physicochemical Characterization and <i>In Vivo</i> Assessment
Development and Optimization of Proniosomal Formulation of Irbesartan Using a Box–Behnken Design to Enhance Oral Bioavailability: Physicochemical Characterization and <i>In Vivo</i> Assessment Open
This research work aimed to develop and evaluate proniosomes for the oral delivery of the lipophilic drug Irbesartan (IRB) to improve its solubility and bioavailability. Proniosomes of Irbesartan were formulated using a lipid, surfactant, …
View article: Chemical and Pharmacological Assessment of Substituted 1,2,4-Triazole Fused Pyrimidines as Anti-microbial Agent
Chemical and Pharmacological Assessment of Substituted 1,2,4-Triazole Fused Pyrimidines as Anti-microbial Agent Open
Objectives: To synthesize a novel series of 3-(Aryl/Heteroaryl)-5-Methyl-7-Phenyl [1,2,4]triazolo[4,3a]Pyrimidines (5a-i). Materials and Methods: Synthesis was carried out though the microwave assisted synthesis, Spectroscopic approaches s…
View article: Effects of Early and Premature Menopause on Women Health
Effects of Early and Premature Menopause on Women Health Open
The families and communities health are no doubt depends on the health of women. Improvement in women health is very essential for achieving gender equality. As per the “World Economic Forum's Gender Gap Report” ranks out of 146 countries …
View article: Design, synthesis, molecular docking and <i>in vitro</i> anticancer activities of 1-(4-(benzamido)phenyl)-3-arylurea derivatives
Design, synthesis, molecular docking and <i>in vitro</i> anticancer activities of 1-(4-(benzamido)phenyl)-3-arylurea derivatives Open
In both premenopausal and postmenopausal women, oestrogens play a critical role in the development of breast cancer.
View article: Biomarkers and theranostics in colorectal cancer
Biomarkers and theranostics in colorectal cancer Open
Colorectal cancer (CRC) is instigated by mutations targeting oncogenes, tumor suppressor genes, and genes connected to the DNA restoration process. Present CRC diagnostics are upgraded by associating it with nonenzymatic tumor markers. Unr…
View article: Novel targeting strategies on signaling pathways of colorectal cancer
Novel targeting strategies on signaling pathways of colorectal cancer Open
Among the most lethal cancers in the world, the rate of colorectal cancer (CRC) increases as on rise in the rate of incidence so the mortality rate also rises, which shows a serious effect on general public health. The causes and progressi…
View article: Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery
Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery Open
Background and Aims: The aim of the present research work was to develop and optimize statistically carvedilol floating beads for chronotherapeutic drug delivery.Methods: Multiple unit floating pulsatile beads of carvedilol were prepared b…
View article: Bioanalytical method development, validation and quantification of flutamide in spiked rat plasma by using high-performance liquid chromatography
Bioanalytical method development, validation and quantification of flutamide in spiked rat plasma by using high-performance liquid chromatography Open
Background A quick, low cost and precise method was developed and validated for flutamide in the rat plasma using a high-performance liquid chromatography. Acetanilide was used as internal standard in the study. Flutamide was extracted fro…
View article: Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent
Design, Synthesis and Biological Screening of Novel Carbazole Tethered Oxyethylamino Derivatives as Antimicrobial Agent Open
Background: Carbazole is an important scaffold known to be associated with several biological activities including antimicrobial activities. Incorporation 4-oxothiazolidine moiety in carbazole moiety may lead to a new series of antimicrobi…
View article: Effect of quercetinon drug induced hepatotoxicity
Effect of quercetinon drug induced hepatotoxicity Open
Objectives-The present study was designed 1. To achieved maximum yield of bioactive extract from the plant through extraction process. 2. To investigated phytochemicals constituents. 3. To determined pharmacological screening of quercetin …
View article: Aromatase Inhibitors: Development and Current Perspectives
Aromatase Inhibitors: Development and Current Perspectives Open
Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in the blood associated with persistently in breast cancer found in many studies. The mechanisms of carcinogenesis whereby cancer is ass…
View article: A Review on Synthesis and Biological Activity of Curcumin and Curcumin Derivatives
A Review on Synthesis and Biological Activity of Curcumin and Curcumin Derivatives Open
Curcumin is a common polyphenolic composite and is the main chemical component of Curcuma longa linn.commonlyknown as turmeric. It is a well-known natural herbal herb traditionally utilized as a flavoring and coloring agent in Indian cooki…
View article: Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization
Sustained Release Bioadhesive Ocular Inserts of Olopatadine Hydrochloride: Formulation and Characterization Open
Objective: To develop bioadhesive ocular inserts of Olopatadine hydrochloride for treating the allergic eye conditions with sustained ocular delivery which will reduce dosing frequency. Methods: Matrix type ocular inserts were prepared by …