M. Fernanda R. P. Proença
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View article: A Correlation-Based Approach for Predicting Humic Substance Bioactivity from Direct Compost Characterization
A Correlation-Based Approach for Predicting Humic Substance Bioactivity from Direct Compost Characterization Open
The efficient characterization of compost quality is essential for optimizing its application in agriculture and soil improvement. In this study, a correlation-based approach was employed to evaluate relationships between physicochemical p…
The Chromenopyridine Scaffold: A Privileged Platform in Drug Design Open
The chromenopyridine scaffold represents an important class of heterocyclic compounds exhibiting a broad spectrum of biological properties. This review describes novel and efficient procedures for the synthesis of this scaffold. Herein, se…
2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives Open
A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A1, A2A, A2B, and A3 adenosine receptor subtypes. Eleven purines showed potent antagonism at A1, A3, dual …
Discovery of 2,9-diaryl-6-carbamoylpurines as a novel class of antitubercular agents Open
A series of novel 9-alkyl/aryl-2-aryl-6-carbamoylpurines were synthesized, and their activity against Mycobacterium tuberculosis strain H37Rv was assessed. The SAR analysis on the first set of derivatives, with an alkyl or aryl unit at N-9…
A simple protocol for the synthesis of perylene bisimides from perylene tetracarboxylic dianhydride Open
PBIs were synthesized from the reaction of perylene bisanhydrides and primary amines in imidazole as solvent. Maleimide, anthraquinone or ferrocene were bonded to the side chain and the S -trityl group was replaced by imidazole in S -trity…
View article: <i>In vitro</i> and <i>in vivo</i> evaluation of novel chromeno[2,3-<i>d</i>]pyrimidinones as therapeutic agents for triple negative breast cancer
<i>In vitro</i> and <i>in vivo</i> evaluation of novel chromeno[2,3-<i>d</i>]pyrimidinones as therapeutic agents for triple negative breast cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance.
Imidazolylpyrrolone‐Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma Open
An in silico study focused on known cancer‐related target proteins, identified a selection of imidazo[4,5‐ b ]pyrrolo[3,4‐ d ]pyridines as potentially active. These compounds were prepared by a novel synthetic approach, designed and develo…
Poly(lactic acid) composites with few layer graphene produced by noncovalent chemistry Open
In recent years, significant attention has been given to “green” product innovation and related manufacturing processes. This work reports the preparation of few‐layer graphene (FLG) and respective PLA‐based composites by an eco‐friendly, …
Acervos virtuais e os modos de presença da arte Open
In dialogue with Rodrigo Duarte’s work, “Modes of Presence in the Contemporary Aesthetic Manifestation”, this paper aims at understanding how the virtualization of aesthetic phenomena disrupts the conditions for sensible apprehension. Reso…
View article: Comparison of a variety of physico-chemical techniques in the chronological characterization of a compost from municipal wastes
Comparison of a variety of physico-chemical techniques in the chronological characterization of a compost from municipal wastes Open
The degree of stability and maturity of the organic matter are fundamental features of the chemical characterization of compost. These characteristics are related to the extensive formation of aromatic structures and of oxygen-containing f…
Regioselective Synthesis of 2-Aryl-5-cyano-1-(2-hydroxyaryl)-1<i>H</i>-imidazole-4-carboxamides Self-Assisted by a 2-Hydroxyaryl Group Open
The reactivity of the diaminomaleonitrile-based imines containing hydroxyphenyl substituents with diverse aromatic aldehydes has been explored for the synthesis of novel highly substituted nitrogen heterocycles, which are considered privil…
Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells Open
Renal cell carcinoma is the most lethal cancer of the urological system due to late diagnosis and treatment resistance. Propolis, a beehive product, is a valuable natural source of compounds with bioactivities and may be a beneficial addit…
View article: Book of Abstracts of the II Symposium in Applied Biochemistry
Book of Abstracts of the II Symposium in Applied Biochemistry Open
[Excerto] The II Symposium in Applied Biochemistry was held online on January 29th 2021, with over 250 participants. \nThe main objectives of the Symposium were to promote the discussion of recent scientific advances in the \nfield of Bioc…
A Simple Method for Anchoring Silver and Copper Nanoparticles on Single Wall Carbon Nanotubes Open
Single walled carbon nanotubes (SWCNT) were functionalized using the 1,3-dipolar cycloaddition reaction of an azomethine ylide under solvent-free conditions, a one-pot procedure that yields pyrrolidine type of groups at the nanotubes surfa…
View article: Characterization of organic matter at different stages of a composting process
Characterization of organic matter at different stages of a composting process Open
The characterization of the organic matter from raw organic wastes, unmatured compost and maturated compost was performed by different techniques: gravimetric, FTIR-ATR, TGA and from the ability of their extracts to bind Cd2+ (evaluating t…
Advanced electrically conductive adhesives for high complexity PCB assembly Open
Electronic packaging, or assembly of packed electronic components on printed circuit boards, present challenges that require innovative solder pastes and electrically conductive adhesives to face the increasing complexity of PCB assembly, …
View article: Influence of the feedstock material on the compost maturity, stability and reactivity
Influence of the feedstock material on the compost maturity, stability and reactivity Open
Compost samples from different origins have been characterized in order to obtain information about their composition, humic-like substances content, maturity and stability. The composts used in the present study were obtained from manure …
New Nitrogen Compounds Coupled to Phenolic Units with Antioxidant and Antifungal Activities: Synthesis and Structure–Activity Relationship Open
A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes 3 was synthesized and cyclized to 2-aryl-4,5-dicyano-1H-imidazoles 4 upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested f…
Water Dispersible Few-Layer Graphene Stabilized by a Novel Pyrene Derivative at Micromolar Concentration Open
The search for graphene or few-layer graphene production methods that are simple, allow mass production, and yield good quality material continues to provoke intense investigation. The present work contributes to this investigation through…
Water Dispersible Few Layer Graphene Stabilized by a Novel Pyrene Derivative at Micromolar Concentration Open
The search for graphene or few layer graphene production methods that are simple, allow mass production and yield good quality material continues to provoke intense investigation. The present work contributes through the study of the aqueo…
Synthesis and biological activity against Mycobacterium tuberculosis of 2,3-dihydroadenine derivatives Open
Purines have attracted attention of the scientific community mainly due to their biological activity [1]. During the last decade, purine derivatives were identified as a promising new class of antitubercular agents. The research was focuse…
An efficient method for dehydration of 6-carbamoylpurines Open
6-cyanopurines of structure 1 (R’=H) were used in our research group to generate novel compounds with high activity against Mycobacterium tuberculosis [1,2]. The synthetic method to generate the cyanopurines 1 only allow a limited number o…
Reactivity of 6-imidatopurines with benzylhydrazine Open
Mycobacterium tuberculosis is a bacterium responsible for thousands of deaths worldwide [1]. Its acquired resistance referred to multi-drug resistance (MDR) is due to the restrictive choice of antibiotics, the prolonged course of therapy, …
View article: Role of Carbonaceous Fragments on the Functionalization and Electrochemistry of Carbon Materials
Role of Carbonaceous Fragments on the Functionalization and Electrochemistry of Carbon Materials Open
Carbonaceous fragments (CF) formed by acid treatment of carbon materials have important properties that are not completely understood. In this work, CF were produced by oxidation of CNT by using mineral acid followed by treatment with NaOH…
Acid catalyzed synthesis of 2-(2-aminophenyl)quinazoline-4-amine and reaction with aromatic aldehydes Open
The hydrochloride salt of 2-(2-aminophenyl)quinazoline-4-amine, prepared from a quinazolino[3,4-a]quinazoline, was reacted with aromatic aldehydes under conventional heating or microwave irradiation, leading to tetracyclic dihydroquinazoli…