Markus R. Meyer
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View article: Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights
Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights Open
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, shows promise in treating depression and post-traumatic stress disorder (PTSD), resulting in breakthrough status. However, concerns regarding MDMA's abuse potential and c…
Optimizing multiomics sample preparation: comparative evaluation of extraction protocols for HepG2 cells Open
Multiomics approaches enable a comprehensive characterization of complex biological systems by simultaneously investigating multiple molecular layers. Generating multiple omics datasets from a single sample is crucial to minimize biologica…
In vitro toxicokinetics and metabolic profiling of methoxycathinones and methylthiocathinones using human liver systems and hyphenated mass spectrometry Open
Ring-substituted synthetic cathinones represent a major subgroup within new psychoactive substances. This study investigated the in vitro toxicokinetics of the three 4-methoxy-substituted representatives 4MeO-NE-BP (4’-methoxy- N -ethylbut…
Clinical Outcomes With Personalized Accelerated Physiologic Pacing in Heart Failure With Preserved Ejection Fraction Open
Importance Patients with heart failure with preserved ejection fraction (HFpEF) and physiologic pacemakers may benefit from pacing rates above the standard 60 beats per minute (bpm). Objective To compare adverse event accrual between perso…
Comprehensive Conduction System Pacing as Antiarrhythmic Strategy in Atrial Fibrillation Open
The current era of pacemaker technology allows for the treatment of cardiac conditions beyond electrical impulse formation or conduction alone. In this report we highlight that comprehensive atrial and ventricular conduction system pacing …
View article: The GAPS programme at TNG LXVIII. Characterization of the outer substellar companion around HD 72659 with a multitechnique approach
The GAPS programme at TNG LXVIII. Characterization of the outer substellar companion around HD 72659 with a multitechnique approach Open
Before discovering the first exoplanets, the radial velocity (RV) method had been used for decades to discover binary stars. Despite significant advancements in this technique, it is limited by the intrinsic mass-inclination degeneracy tha…
A Comparative Study Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography to Investigate the In Vitro and In Vivo Metabolism of Five Selenium-Containing Cathinone Derivatives Open
Background/Objectives: The emergence of cathinone-based psychostimulants necessitates ongoing research and analysis of the characteristics and properties of novel derivatives. The metabolic fate of five novel cathinone-derived substances (…
Medication adherence in patients with acutely decompensated heart failure: A cross‐sectional study in the emergency department ( <span>ADHF</span> ‐ <span>ED</span> ) Open
Aims Non‐adherence to guideline‐directed medical therapy may worsen outcomes in chronic heart failure (CHF). Objectively assessed adherence in patients presenting with acutely decompensated heart failure (ADHF) remains largely unexplored. …
Laminar Flow Alters EV Composition in HUVECs: A Study of Culture Medium Optimization and Molecular Profiling of Vesicle Cargo Open
Endothelial cells (ECs) experience shear stress associated with blood flow. Such shear stress regulates endothelial function by altering cell physiology. Since most cell culture protocols and media compositions are designed for static cult…
View article: Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing
Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing Open
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP w…
View article: The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities
The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities Open
The proton therapy facility in Dresden, Germany, has one treatment room equipped with a rotating gantry where patients are treated and an experimental room equipped with two horizontal beamlines for translational research. The present work…
Overcoming limitations in exhaled breath aerosol analysis – Untargeted breathomics for the identification of endogenous breath biomarkers using LC-HRMS/MS Open
This study represents a step forward in overcoming the current limitation of EB analysis, the lack of standardization in sampling procedure. Nevertheless, further investigation including correlation studies and more diverse populations wil…
View article: The SPHERE infrared survey for exoplanets (SHINE)
The SPHERE infrared survey for exoplanets (SHINE) Open
Context. Over the past decade, large surveys with state-of-the-art planet-finder instruments such as Spectro-Polarimetric High-contrast Exoplanet REsearch on board Very Large Telescope (SPHERE@VLT), coupled with coronagraphic devices and e…
The proteomic landscape of trophoblasts unravels calcium-dependent syncytialization processes and beta-chorionic gonadotropin (ß-hCG) production Open
Background The syncytiotrophoblast (STB) layer of the placenta is formed by cell fusion of cytotrophoblasts, acts as a feto-maternal barrier, is required for the production of pregnancy hormones such as chorionic gonadotropin, estradiol an…
View article: The SPHERE infrared survey for exoplanets (SHINE). V. Complete observations, data reduction and analysis, detection performances, and final results
The SPHERE infrared survey for exoplanets (SHINE). V. Complete observations, data reduction and analysis, detection performances, and final results Open
During the past decade, state-of-the-art planet-finder instruments like SPHERE@VLT, coupling coronagraphic devices and extreme adaptive optics systems, unveiled, thanks to large surveys, around 20 planetary mass companions at semi-major ax…
Comprehensive Qualitative Drug Screening in Emergency Toxicology Using an Automated LC–MS<sup>n</sup> System:Simultaneous Quantification of Relevant Drugs and Metabolites in Blood Plasma Open
Rapid and comprehensive qualitative and quantitative analytical procedures are crucial in 24/7 emergency toxicology (ET) to support diagnosis and treatment of acute intoxications and to monitor their progression and efficacy of detoxificat…
View article: Commissioning of the MIRAC-5 Mid-infrared Instrument on the MMT
Commissioning of the MIRAC-5 Mid-infrared Instrument on the MMT Open
We present results from commissioning observations of the mid-IR instrument, MIRAC-5, on the 6.5 m MMT telescope. MIRAC-5 is a novel ground-based instrument that utilizes a state-of-the-art GeoSnap (2–13 µ m) HgCdTe detector with adaptive …
Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening Open
Wastewater (WW)‐based epidemiology (WBE) is a powerful tool for screening and surveillance of drugs (of abuse) or new psychoactive substances (NPSs) in larger population. Since the drug market changes frequently, it is crucial for WBE to d…
View article: Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs
Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs Open
Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker, which can potentially lead to al…
View article: Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration
Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration Open
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not u…
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial Open
Background and Aims Patients with heart failure with preserved ejection fraction (HFpEF) tend to have low resting and exercise heart rates. Phosphodiesterase‐3 (PDE‐3) inhibitors improve heart rates, haemodynamics and symptoms in patients …
View article: Large Interferometer For Exoplanets (LIFE). XIV. Finding terrestrial protoplanets in the galactic neighborhood
Large Interferometer For Exoplanets (LIFE). XIV. Finding terrestrial protoplanets in the galactic neighborhood Open
The increased brightness temperature of young rocky protoplanets during their magma ocean epoch makes them potentially amenable to atmospheric characterization to distances from the solar system far greater than thermally equilibrated terr…
View article: Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs
Are the postmortem concentration changes of the synthetic cannabinoid cumyl-5F-P7AICA and its N-pentanoic acid metabolite dependent on the environmental conditions? – A systematic study following pulmonary administration to pigs Open
The number of fatal cases involving synthetic cannabinoids (SCs) is increasing. However, interpretation of postmortem (PM) toxicological findings is challenging, due to unknown PM intervals and possible redistribution processes or instabil…