Mohamed M. Radwan
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View article: Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities
Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities Open
Carotol, the major sesquiterpene alcohol in carrot essential oil, possesses notable cytotoxic activity against various cancer cell lines, yet its metabolic fate remains poorly understood. This study explored microbial biotransformation as …
View article: Development and Validation of an HPLC–UV/PDA Method for the Determination of Cannflavins in Different Cannabis sativa Chemovars
Development and Validation of an HPLC–UV/PDA Method for the Determination of Cannflavins in Different Cannabis sativa Chemovars Open
Cannabis sativa (C. sativa) is a psychoactive plant that has been used for millennia for medicinal, recreational, and industrial purposes. The main constituents of cannabis are the cannabinoids, with other constituents including terpenes a…
View article: Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers Open
Background: Nicotinamide-based VEGFR-2 inhibitors have good contribution in drug discovery. Aim: Development of novel nicotinamides as VEGFR-2 inhibitors. Methods: different in vitro and in silico assays were conducted to evaluate the VEGF…
View article: Development and in vitro Evaluation of Cannabidiol Mucoadhesive Buccal Film Formulations Using Hot-Melt Extrusion Technology
Development and in vitro Evaluation of Cannabidiol Mucoadhesive Buccal Film Formulations Using Hot-Melt Extrusion Technology Open
Introduction: Cannabidiol (CBD) has sparked considerable interest because of its wide range of pharmacological uses and the fact that it does not induce psychoactive effects. CBD formulation development presents significant challenges due …
View article: A 10-year trend in cannabis potency (2013–2022) in different geographical regions of the United States of America
A 10-year trend in cannabis potency (2013–2022) in different geographical regions of the United States of America Open
Background The prevalence of cannabis as the most commonly used illicit substance in the United States and around the globe is well-documented. Studies have highlighted a noticeable uptrend in the potency of cannabis in the United states. …
View article: Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol Open
Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern hemisphere, its use has moved and flourished in the Western nations in…
View article: Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol Open
Cannabis sativa is one of the oldest plants utilized by humans for both economic and medical purposes. Although the use of cannabis started millennia ago in the Eastern part of the hemisphere, its use has moved and flourished in the Wester…
View article: Effect of Gamma Irradiation on Cannabinoid, Terpene, and Moisture Content of Cannabis Biomass
Effect of Gamma Irradiation on Cannabinoid, Terpene, and Moisture Content of Cannabis Biomass Open
In recent years, cannabis has been proposed and promoted not only as a medicine for the treatment of a variety of illnesses, but also as an industrial crop for different purposes. Being an agricultural product, cannabis inflorescences may …
View article: A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, <i>in silico</i> and <i>in vitro</i> Studies
A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, <i>in silico</i> and <i>in vitro</i> Studies Open
A computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐ N ‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, ( T‐1‐APFPB ), following the pharmacophoric features of V…
View article: Chemistry and Biological Activities of Cannflavins of the Cannabis Plant
Chemistry and Biological Activities of Cannflavins of the Cannabis Plant Open
Background: Throughout history, Cannabis has had a significant influence on human life as one of the earliest plants cultivated by humans. The plant was a source of fibers used by the oldest known civilizations. Cannabis was also used medi…
View article: Oral Ulcers as A Manifestation Of COVID-19 Infection: A Cross-Sectional Study in Egypt
Oral Ulcers as A Manifestation Of COVID-19 Infection: A Cross-Sectional Study in Egypt Open
Objectives This study aimed to examine the prevalence of oral ulcers in COVID-19 patients within the Egyptian population, while considering potential risk factors, assessing pain intensity, and exploring the implications for early detectio…
View article: Periodic Orbits Around the Triangular Points with Prolate Primaries
Periodic Orbits Around the Triangular Points with Prolate Primaries Open
Periodic orbits play a fundamental role in the study and deep understanding of the behavior of dynamical systems. In the current work, we investigated the periodic orbits around the triangular libration points of the restricted three-body …
View article: Association Between Vitamin D Deficiency and Serum Ferritin and Preterm Labor: A Case Control Study
Association Between Vitamin D Deficiency and Serum Ferritin and Preterm Labor: A Case Control Study Open
Background: One of the main factors contributing to prenatal morbidity and death is preterm birth. There have been some investigations describing the connection between vitamin D deficiency and serum ferritin during gestation and increasin…
View article: Influence of Thermo-mechanical Aging on Straight versus Angled Multi-Unit Abutments Screw Joint Stability
Influence of Thermo-mechanical Aging on Straight versus Angled Multi-Unit Abutments Screw Joint Stability Open
Purpose: Evaluate the screw joint stability of the straight versus angled Multi-Unit (MU) abutment following dynamic cyclic loading and thermo-cycling aging.Methods: This study compared abutment screws reverse torque values (RTVs) using th…
View article: Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS
Antitrypanosomal, Antitopoisomerase-I, and Cytotoxic Biological Evaluation of Some African Plants Belonging to Crassulaceae; Chemical Profiling of Extract Using UHPLC/QTOF-MS/MS Open
In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the Crassulaceae family have been selected for the present study. Sedum sieboldii leaves extr…
View article: Quantitative Determination of Cannabis Terpenes Using Gas Chromatography-Flame Ionization Detector
Quantitative Determination of Cannabis Terpenes Using Gas Chromatography-Flame Ionization Detector Open
Background: Cannabis has a long history of being credited with centuries of healing powers for millennia. The cannabis plant is a rich source of cannabinoids and terpenes. Each cannabis chemovar exhibits a different flavor and aroma, which…
View article: Development and Validation of a GC-FID Method for the Quantitation of 20 Different Acidic and Neutral Cannabinoids
Development and Validation of a GC-FID Method for the Quantitation of 20 Different Acidic and Neutral Cannabinoids Open
For decades, Cannabis sativa had been illegal to sell or consume around the world, including in the United States. However, in light of the recent 2018 Farm Bill and the legalization of hemp across the US, various cannabis preparations hav…
View article: Flexural Performance of Concrete Structures Reinforced with Fiber Reinforced Polymer (FRP)
Flexural Performance of Concrete Structures Reinforced with Fiber Reinforced Polymer (FRP) Open
ne of the most recent uses of FRP is to replace the use of steel in reinforced concrete structures. There are multiple reasons for deciding to choose FRP instead of steel such as their lightweight which can be quite beneficial to the desig…
View article: Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of <i>Cannabis sativa</i> Varieties
Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of <i>Cannabis sativa</i> Varieties Open
Background: Phytocannabinoids naturally occur in the cannabis plant (Cannabis sativa), and Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) predominate. There is a need for rapid inexpensive methods to quantify total THC (for statutory …
View article: Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis
Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis Open
Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into western medicine during the early 19th century. It contains a complex mixture of secondary metabolites, including cannabinoids and non-cannabinoid-t…
View article: swab me, i am infected!
swab me, i am infected! Open
In the late December 2019 an outbreak of a novel coronavirus termed as SARS-CoV-2 has emerged in Wuhan city, China then spread worldwide to cause serious life threatening pandemic that seriously affect the economics and daily life.The clas…
View article: Validating a predictive model of cannabinoid inheritance with feral, clinical, and industrial <i>Cannabis sativa</i>
Validating a predictive model of cannabinoid inheritance with feral, clinical, and industrial <i>Cannabis sativa</i> Open
Premise How genetic variation within a species affects phytochemical composition is a fundamental question in botany. The ratio of two specialized metabolites in Cannabis sativa , tetrahydrocannabinol (THC) and cannabidiol (CBD), can be gr…
View article: A Validated UPLC-PDA Method for Simultaneous Determination of 3 Biologically Active Isoflavans in <i>Trigonella stellata</i> Extract
A Validated UPLC-PDA Method for Simultaneous Determination of 3 Biologically Active Isoflavans in <i>Trigonella stellata</i> Extract Open
In this study, an ultra-performance liquid chromatography (UPLC)/photodiode array method was developed for the simultaneous determination of trigonellan glucoside (1), isotrigonellan (2), and methoxy-isotrigonellan (3) in Trigonella stella…