M. N. V. Ravi Kumar
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View article: Dual-function polyester nanoparticles for amplified anti-inflammatory effects
Dual-function polyester nanoparticles for amplified anti-inflammatory effects Open
This study investigates a dual-acting drug delivery system using naringenin (NAR) as a folate receptor ligand to enhance intestinal uptake and encapsulated NAR for combating inflammation. The dual-acting systems were tested in vitro on cis…
View article: Role of Pharmacovigilance Programme of India (PvPI) in Adverse Drug Event Monitoring for medication safety in patient
Role of Pharmacovigilance Programme of India (PvPI) in Adverse Drug Event Monitoring for medication safety in patient Open
A pharmacovigilance system is a specialized domain within the pharmacological sciences that pertains to the reporting of Adverse Event Reactions associated with medical devices and pharmaceuticals. An adverse event represents a potential p…
View article: UPLC-MS/MS Method for Simultaneous Quantification of Cyclosporine A and Urolithin A in Plasma and Interspecies Analysis Across Mammals Including Humans
UPLC-MS/MS Method for Simultaneous Quantification of Cyclosporine A and Urolithin A in Plasma and Interspecies Analysis Across Mammals Including Humans Open
In the past decade, liquid chromatography-mass spectrometry (LC-MS/MS) has become pivotal in clinical diagnosis, drug discovery, and bioanalytical science due to its high sensitivity and rapid analysis. We have developed an ultrasensitive …
View article: Nanotechnology-Enhanced Naloxone and Alternative Treatments for Opioid Addiction
Nanotechnology-Enhanced Naloxone and Alternative Treatments for Opioid Addiction Open
Opioids are commonly prescribed to address intense, ongoing pain associated with cancer, as well as long-lasting noncancer-related pain when alternative methods have proven ineffective. Individuals who exhibit both chronic pain and misuse …
View article: ZnPP‐laden nanoparticles improve glucose homeostasis and chronic inflammation during obesity
ZnPP‐laden nanoparticles improve glucose homeostasis and chronic inflammation during obesity Open
Background and Purpose Chronic inflammation plays a pivotal role in the development of Type 2 diabetes mellitus (T2DM). Previous studies have shown that haem oxygenase‐1 (HO‐1) plays a proinflammatory role during metabolic stress, suggesti…
View article: Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats
Oral Nanocurcumin Alone or in Combination with Insulin Alleviates STZ-Induced Diabetic Neuropathy in Rats Open
Diabetes mellitus (DM), a multifaceted metabolic disorder if not managed properly leads to secondary complications. Diabetic peripheral neuropathy (DPN) is one such complication caused by nerve damage that cannot be reversed but can be del…
View article: Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an <i>Ex Vivo</i> Rat Eye Model
Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an <i>Ex Vivo</i> Rat Eye Model Open
Neurovascular eye problems are better prevented than managed or treated. Despite growing concern of occurrence in aging populations and development secondary to diseases such as diabetes and hypertension, we currently have very few options…
View article: Urolithin A Nanoparticle Therapy for Cisplatin-Induced Acute Kidney Injury
Urolithin A Nanoparticle Therapy for Cisplatin-Induced Acute Kidney Injury Open
Cisplatin continues to be one of the frontline cytotoxic drugs. However, cisplatin-induced acute kidney injury (AKI) remains a major unmet medical need without any approved pharmacological interventions. The involvement of reactive oxygen …
View article: In vitro Pharmacognostical, Phytochemical and Pharmacological evaluation of Tradescantia spathacea: An exploration
In vitro Pharmacognostical, Phytochemical and Pharmacological evaluation of Tradescantia spathacea: An exploration Open
Nature has given us a vast array of medicines to treat various chronic and acute illnesses.It is estimated that over 80% of the global population is reliant on traditional medicine for their main health care.Herbal remedies have been used …
View article: Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation
Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation Open
Orally delivered double-headed nanoparticle curcumin has potential to treat intraocular inflammation.
View article: A highly potent lymphatic system–targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus
A highly potent lymphatic system–targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus Open
Orally delivered lymphatic system–specific nanoparticle cyclosporine is an effective way to treat lupus.
View article: Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa
Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa Open
Herpes Simplex Virus Type 2 (HSV-2) is one of the most prevalent sexually transmitted viruses and is a known risk factor for HIV acquisition in the Female Genital Tract (FGT). Previously, we found that curcumin can block HSV-2 infection an…
View article: Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI
Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI Open
The popular anticancer drug cisplatin causes many adverse side effects, the most serious of which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies suggests that the AKI pathogenesis involves oxidative st…
View article: Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome
Low-Dose Curcumin Nanoparticles Normalise Blood Pressure in Male Wistar Rats with Diet-Induced Metabolic Syndrome Open
Nanoparticle formulations improve bioavailability and so may allow low-dose formulations of food-derived compounds such as curcumin to attenuate chronic systemic disease despite intrinsically low oral bioavailability. The current study ind…
View article: Next-Generation Noncompetitive Nanosystems Based on Gambogic Acid:<i>In Silico</i>Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and Their Preliminary Safety in Healthy Rodents
Next-Generation Noncompetitive Nanosystems Based on Gambogic Acid:<i>In Silico</i>Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and Their Preliminary Safety in Healthy Rodents Open
A major challenge in drug delivery is to enhance the transport of drugs across biological barriers, such as the small intestine, the blood-brain barrier, and the blood-retinal/ocular barrier, and to effectively reach the site of action whi…
View article: Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy
Polyester Nanoparticle Encapsulation Mitigates Paclitaxel-Induced Peripheral Neuropathy Open
Chemotherapy utilizing cytotoxic drugs, such as paclitaxel (PTX), is still a commonly used therapeutic approach to treat both localized and metastasized cancers. Unlike traditional regimens in which PTX is administered at the maximum toler…
View article: Double-headed nanosystems for oral drug delivery
Double-headed nanosystems for oral drug delivery Open
We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces.
View article: Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus
Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus Open
Background and Purpose Approaches to prevent selective and progressive loss of insulin‐producing beta cells in Type 1 diabetes mellitus (T1DM) will help to manage this prevalent and devastating disease. Curcumin (CUR), a natural anti‐infla…
View article: The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizing Gambogic Acid as a Ligand
The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizing Gambogic Acid as a Ligand Open
The current methods for targeted drug delivery utilize ligands that must out-compete endogenous ligands in order to bind to the active site facilitating the transport. To address this limitation, we present a non-competitive active transpo…