Martin Risch
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View article: A-222 Evaluating Hemolytic, Lipemic, and Icteric Index Stability in Drone-Transported Blood Samples: Implications for Modern Medical Logistics
A-222 Evaluating Hemolytic, Lipemic, and Icteric Index Stability in Drone-Transported Blood Samples: Implications for Modern Medical Logistics Open
Background Maintaining the integrity of blood samples during transport is essential for accurate laboratory diagnostics. Hemolytic, lipemic, and icteric (HIL) indices are critical preanalytical markers that detect hemolysis, lipemia, and i…
View article: A-221 Impact of Repeated Drone Transport on Blood Sample Integrity: A Focused Analysis
A-221 Impact of Repeated Drone Transport on Blood Sample Integrity: A Focused Analysis Open
Background The increasing adoption of drones in medical logistics raises concerns about the potential cumulative effects of repeated transport on the quality of blood samples and the variability in laboratory results. This study investigat…
View article: Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome – a new kidney disorder defining selective glomerular hypofiltration syndromes – calls for expansion of the international KDIGO guidelines
Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome – a new kidney disorder defining selective glomerular hypofiltration syndromes – calls for expansion of the international KDIGO guidelines Open
Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) - a new kidney disorder - in 2015. Since th…
View article: Remote early detection of SARS-CoV-2 infections using a wearable-based algorithm: Results from the COVID-RED study, a prospective randomised single-blinded crossover trial
Remote early detection of SARS-CoV-2 infections using a wearable-based algorithm: Results from the COVID-RED study, a prospective randomised single-blinded crossover trial Open
Background Rapid and early detection of SARS-CoV-2 infections, especially during the pre- or asymptomatic phase, could aid in reducing virus spread. Physiological parameters measured by wearable devices can be efficiently analysed to provi…
View article: Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae
Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae Open
The NG & DR assay demonstrated promising results for the molecular prediction of ciprofloxacin resistance and susceptibility, expanding the potential diagnostic tool kit for individualized patient treatment. Furthermore, it might serve as …
View article: Current Advancements in Drone Technology for Medical Sample Transportation
Current Advancements in Drone Technology for Medical Sample Transportation Open
Background: The integration of drone technology into healthcare logistics presents a significant opportunity to enhance the speed, reliability, and efficiency of medical sample transportation. Methods: This paper provides a narrative revie…
View article: B-125 Laboratory Profiles for Diagnostic Workup of Acute Abdominal Pain in the Emergency Department: A Comparative Study of University and Non-University Acute Care Hospitals in Germany and Switzerland
B-125 Laboratory Profiles for Diagnostic Workup of Acute Abdominal Pain in the Emergency Department: A Comparative Study of University and Non-University Acute Care Hospitals in Germany and Switzerland Open
Background Laboratory medicine plays a fundamental role in patient care, especially in emergency departments where rapid diagnosis is critical to the efficient management of high patient volumes. With the aim of simplifying and standardizi…
View article: Preanalytic Integrity of Blood Samples in Uncrewed Aerial Vehicle (UAV) Medical Transport: A Comparative Study
Preanalytic Integrity of Blood Samples in Uncrewed Aerial Vehicle (UAV) Medical Transport: A Comparative Study Open
The integration of unmanned aerial vehicles or uncrewed aerial vehicles (UAVs)—commonly known as drones—into medical logistics offers transformative potential for the transportation of sensitive medical materials, such as blood samples. Tr…
View article: A Green Laboratory Approach to Medical Sample Transportation: Assessing the Carbon Dioxide (CO2) Footprint of Medical Sample Transportation by Drone, Combustion Car, and Electric Car
A Green Laboratory Approach to Medical Sample Transportation: Assessing the Carbon Dioxide (CO2) Footprint of Medical Sample Transportation by Drone, Combustion Car, and Electric Car Open
In response to escalating climate change concerns, this study evaluates the ecological impact and efficiency of medical sample transportation using drones, combustion cars, and electric cars across various terrains and weather conditions i…
View article: Current Advancements in Drone Technology for Medical Sample Transportation
Current Advancements in Drone Technology for Medical Sample Transportation Open
The integration of drone technology into healthcare logistics presents a significant opportunity to enhance the speed, reliability, and efficiency of medical sample transportation. This study inves-tigates the current advancements in drone…
View article: A Green Laboratory Approach to Medical Sample Transportation: Assessing the Carbon Dioxide (CO2) Footprint of Medical Sample Transportation by Drone, Combustion Car, and Electric Car
A Green Laboratory Approach to Medical Sample Transportation: Assessing the Carbon Dioxide (CO2) Footprint of Medical Sample Transportation by Drone, Combustion Car, and Electric Car Open
Background: Amidst escalating climate change concerns, sustainable practices in healthcare logistics are critical. This study evaluates the ecological impact and efficiency of medical sample transportation using drones, combustion cars, an…
View article: Unmanned High-Speed Aerial Vehicles in Medical Logistics: A Comprehensive Comparative Analysis of Blood Sample Transportation with Weather Variability
Unmanned High-Speed Aerial Vehicles in Medical Logistics: A Comprehensive Comparative Analysis of Blood Sample Transportation with Weather Variability Open
Background: The integration of unmanned aerial vehicles (UAVs), commonly known as drones, into medical logistics offers transformative potential for the transpor-tation of sensitive medical materials, such as blood samples. Traditional car…
View article: Comparison of two different technologies measuring the same analytes in view of the <i>In Vitro</i> Diagnostic Regulation (IVDR)
Comparison of two different technologies measuring the same analytes in view of the <i>In Vitro</i> Diagnostic Regulation (IVDR) Open
Objectives This study systematically compared the performance and comparability of two medical laboratory analytical instruments, the conventional wet chemistry analyzer (cobas) and the dry slide technology (Vitros), across various clinica…
View article: Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study)
Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study) Open
Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. A wearable medical device measured breath…
View article: In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides
In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides Open
Purpose Single doses of gentamicin have demonstrated clinical efficacy in the treatment of urogenital gonorrhea, but lower cure rates for oropharyngeal and anorectal gonorrhea. Formulations selectively enriched in specific gentamicin C con…
View article: S-Gene Target Failure as an Effective Tool for Tracking the Emergence of Dominant SARS-CoV-2 Variants in Switzerland and Liechtenstein, Including Alpha, Delta, and Omicron BA.1, BA.2, and BA.4/BA.5
S-Gene Target Failure as an Effective Tool for Tracking the Emergence of Dominant SARS-CoV-2 Variants in Switzerland and Liechtenstein, Including Alpha, Delta, and Omicron BA.1, BA.2, and BA.4/BA.5 Open
During the SARS-CoV-2 pandemic, the Dr. Risch medical group employed the multiplex TaqPathTM COVID-19 CE-IVD RT-PCR Kit for large-scale routine diagnostic testing in Switzerland and the principality of Liechtenstein. The TaqPath Kit is a w…
View article: SARS-CoV-2 Nucleocapsid Protein Mutations Found in Switzerland Disrupt N-Gene Amplification in Commonly Used Multiplex RT-PCR Assay
SARS-CoV-2 Nucleocapsid Protein Mutations Found in Switzerland Disrupt N-Gene Amplification in Commonly Used Multiplex RT-PCR Assay Open
At the end of 2021, we observed an increase in N-gene target failures (NGTF) with the TaqPathTM COVID-19 CE-IVD RT-PCR Kit from Thermo Fisher Scientific (TaqPath). We subsequently used whole-genome sequencing (Oxford Nanopore Technology) t…
View article: Genetic predisposition to high blood pressure and out-of-office hypertension: insights from a population sample in Liechtenstein
Genetic predisposition to high blood pressure and out-of-office hypertension: insights from a population sample in Liechtenstein Open
Genetic predisposition is a risk factor for office hypertension. We tested whether genetic background could identify individuals with ambulatory daytime hypertension in a sample of white Europeans from Liechtenstein. We evaluated two measu…
View article: Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study)
Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study) Open
Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. A wearable medical device measured breath…
View article: The Association of suPAR with Cardiovascular Risk Factors in Young and Healthy Adults
The Association of suPAR with Cardiovascular Risk Factors in Young and Healthy Adults Open
The soluble urokinase plasminogen activator receptor (suPAR), as a correlate of chronic low-grade inflammation, may be used to predict individual cardiovascular risk. Since chronic low-grade inflammation is thought to be associated with th…
View article: IVDR: Analysis of the Social, Economic, and Practical Consequences of the Application of an Ordinance of the In Vitro Diagnostic Ordinance in Switzerland
IVDR: Analysis of the Social, Economic, and Practical Consequences of the Application of an Ordinance of the In Vitro Diagnostic Ordinance in Switzerland Open
IVDR regulation represents a major challenge for diagnostic microbiology laboratories. IVDR complicates a broad range of aspects and poses a risk given the high diversity of pathogens (including rare but highly virulent microbes) and the l…
View article: Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study
Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study Open
It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (…
View article: Mortality risk factors in community-dwelling, subjectively healthy, Swiss older adults: update after 8-years follow-up
Mortality risk factors in community-dwelling, subjectively healthy, Swiss older adults: update after 8-years follow-up Open
Background Worldwide population is ageing, but little is known regarding risk factors associated with increased mortality in subjectively healthy, community-dwelling older adults. We present the updated results of the longest follow-up car…
View article: Ancient methicillin-resistant<i>Staphylococcus aureus</i>: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection
Ancient methicillin-resistant<i>Staphylococcus aureus</i>: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection Open
Few methicillin-resistant Staphylococcus aureus (MRSA) from the early years of its global emergence have been sequenced. Knowledge about evolutionary factors promoting the success of specific MRSA multi-locus sequence types (MLSTs) remains…
View article: The role of serum brain injury biomarkers in individuals with a mild-to-moderate COVID infection and Long-COVID - results from the prospective population-based COVI-GAPP study
The role of serum brain injury biomarkers in individuals with a mild-to-moderate COVID infection and Long-COVID - results from the prospective population-based COVI-GAPP study Open
Background During and after mild (no hospitalization) or moderate (hospitalization without ICU) SARS-CoV-2 infections, a wide range of symptoms, including neurological disorders have been reported. It is, however, unknown if these neurolog…
View article: Genetic Predisposition to High Blood Pressure and Out-of-Office Hypertension: Insights from a Population Sample in Liechtenstein
Genetic Predisposition to High Blood Pressure and Out-of-Office Hypertension: Insights from a Population Sample in Liechtenstein Open
Genetic predisposition is a risk factor for office hypertension. We tested whether genetic background could identify individuals with ambulatory daytime hypertension in a sample of white Europeans from Liechtenstein. We evaluated two measu…
View article: Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery - the prospective-randomized, microbiologist-blinded, stratified, superiority Trials - BAPTIST trials
Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery - the prospective-randomized, microbiologist-blinded, stratified, superiority Trials - BAPTIST trials Open
Background: The perioperative antibiotic prophylaxis with 1 st or 2 nd -generation cephalosporins is evidence-based in orthopedic surgery. There are, however, situations with a high risk of prophylaxis-resistant surgical site infections (S…
View article: The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation Open
Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has res…