Background Rapid and early detection of SARS-CoV-2 infections, especially during the pre- or asymptomatic phase, could aid in reducing virus spread. Physiological parameters measured by wearable devices can be efficiently analysed to provide early detection of infections. The COVID-19 Remote Early Detection (COVID-RED) trial investigated the use of a wearable device (Ava bracelet) for improved early detection of SARS-CoV-2 infections in real-time. Trial design Prospective, single-blinded, two-period, two-sequence,…

Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) - a new kidney disorder - in 2015. Since then, it has been shown that cystatin C in many aspects is superior to creatinine as a marker of GFR and cardiovascular risk. SPS, an entity within the selective glomerular hypofiltration syndromes (SGHS), has been demonstrated to be associated with a strong increase in morbidity a…

The NG & DR assay demonstrated promising results for the molecular prediction of ciprofloxacin resistance and susceptibility, expanding the potential diagnostic tool kit for individualized patient treatment. Furthermore, it might serve as a surveillance tool for azithromycin nonwild-type strains.

Abstract Background Maintaining the integrity of blood samples during transport is essential for accurate laboratory diagnostics. Hemolytic, lipemic, and icteric (HIL) indices are critical preanalytical markers that detect hemolysis, lipemia, and icterus, which can interfere with diagnostic results. With the growing interest in drones as a method of medical transport, particularly for remote or underserved areas, it is crucial to evaluate their impact on the stability of HIL indices. This study investigates whethe…

Abstract Background The increasing adoption of drones in medical logistics raises concerns about the potential cumulative effects of repeated transport on the quality of blood samples and the variability in laboratory results. This study investigates the stability of 35 analytes, including potassium, thrombocytes, international normalized ratio (INR), Quick value, and activated partial thromboplastin time (aPTT), over ten consecutive drone transport cycles, focusing on four blood types: serum, EDTA plasma, lithium…