Thomas Ryll
YOU?
Author Swipe
View article: Comprehensive manipulation of glycosylation profiles across development scales
Comprehensive manipulation of glycosylation profiles across development scales Open
The extent and pattern of glycosylation on therapeutic antibodies can influence their circulatory half-life, engagement of effector functions, and immunogenicity, with direct consequences to efficacy and patient safety. Hence, controlling …
View article: Innovation in Cell Banking, Expansion, and Production Culture
Innovation in Cell Banking, Expansion, and Production Culture Open
Cell culture-based production processes enable the development and commercial supply of recombinant protein products. Such processes consist of the following elements: thaw and initiation of culture, seed expansion, and production culture.…
View article: The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry
The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry Open
Antibody-drug conjugates (ADCs) are promising biotherapeutic agents for the treatment of cancer. The careful monitoring of critical quality attributes is important for ADCs' development, manufacturing and production. In this work, the effe…