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View article: Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A
Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A Open
The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes β-catenin has been a subject of debate over the last four decades. Casein kinase 1α (CK1α) functions as a pivotal negative regulator…
View article: GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation
GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation Open
Induced pluripotent stem cells (iPSCs) are useful tools for modeling diseases and developing personalized medicine. We have been developing cancer stem cells (CSCs) from iPSCs with conditioned medium (CM) of cancer-derived cells as the mim…
View article: Up-regulation of Dsg2 confered stem cells with malignancy through wnt/β-catenin signaling pathway
Up-regulation of Dsg2 confered stem cells with malignancy through wnt/β-catenin signaling pathway Open
In the previous study, we originally developed cancer stem cells (CSCs) models from mouse induced pluripotent stem cells (miPSCs) by culturing miPSCs in the conditioned medium of cancer cell lines, which mimiced as carcinoma microenvironme…
View article: Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways
Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open
Background Cancer stem cells (CSCs) are generated under irregular microenvironment in vivo, of which mimic is quite difficult due to the lack of enough information of the factors responsible for cancer initiation. Here, we demonstrated tha…
View article: The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells
The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells Open
Cancer stem cells (CSCs) are capable of continuous proliferation, self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. We have established a model of CSCs that was original…
View article: Additional file 3 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways
Additional file 3 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open
Additional file 3: Supplementary Table 3
View article: Additional file 1 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways
Additional file 1 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open
Additional file 1: Supplementary Table 1
View article: Additional file 2 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways
Additional file 2 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open
Additional file 2: Supplementary Table 2
View article: Additional file 4 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways
Additional file 4 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open
Additional file 4: Supplementary Table 5
View article: The Efficacy of PI3Kγ and EGFR Inhibitors on the Suppression of the Characteristics of Cancer Stem Cells
The Efficacy of PI3Kγ and EGFR Inhibitors on the Suppression of the Characteristics of Cancer Stem Cells Open
Cancer stem cells (CSCs) are capable of continuous proliferation, self-renewal and are proposed to play significant roles in oncogenesis, tumor growth, metastasis and cancer recurrence. We have established a model of CSCs that was original…
View article: Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy
Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy Open
The immune system has been found to be suppressed in cancer patients. Cancer cells are extremely resistant to chemotherapeutic drugs, conventional immunotherapy, or cancer antigen vaccine therapy. Cancer immunotherapy, which is mainly base…
View article: Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy
Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy Open
Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism that disrupts the dynamics of microtubules and induces mitotic …
View article: Isolation and characterization of cancer stem cells derived from human glioblastoma.
Isolation and characterization of cancer stem cells derived from human glioblastoma. Open
Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis. Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues due to their differentiation potential. However, the characterizatio…
View article: Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells.
Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells. Open
Breast cancer is the first common cause of cancer-related death in women worldwide. Since the malignancy and aggressiveness of breast cancer have been correlated with the presence of breast cancer stem cells, the establishment of a disease…
View article: Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro
Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro Open
Defined by its potential for self-renewal, differentiation and tumorigenicity, cancer stem cells (CSCs) are considered responsible for drug resistance and relapse. To understand the behavior of CSC, the effects of the microenvironment in e…
View article: Metastasis Model of Cancer Stem Cell-Derived Tumors
Metastasis Model of Cancer Stem Cell-Derived Tumors Open
Metastasis includes the dissemination of cancer cells from a malignant tumor and seed in distant sites inside the body forming secondary tumors. Metastatic cells from the primary tumor can move even before the cancer is detected. Therefore…
View article: Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment
Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment Open
Cancer stem cells (CSCs) are a class of cancer cells characterized by self-renewal, differentiation and tumorigenic potential. We previously established a model of CSCs by culturing mouse induced pluripotent stem cells (miPSCs) for four we…
View article: Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells
Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells Open
“Combination therapy”, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. The combination of anticancer drugs, of which functions are different from the other, enhances th…
View article: Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs
Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs Open
The tumor microenvironment (TME) has an essential role in tumor initiation and development. Tumor cells are considered to actively create their microenvironment during tumorigenesis and tumor development. The TME contains multiple types of…
View article: Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells
Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells Open
Background: Cancer stem cells (CSCs) as a class of malignant cancer cells play an important role in tumor progression. Previous studies by our group have demonstrated the establishment of the model of CSCs converting mouse iPS cells (miPSC…
View article: Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells
Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells Open
Cancer stem cells (CSCs) represent the subpopulation of cancer cells with the ability to differentiate into other cell phenotypes and initiated tumorigenesis. Previously, we reported generating CSCs from mouse induced pluripotent stem cell…
View article: Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma
Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma Open
Metastasis develops when cancer cells spread from the primary site of a malignant tumor to the surrounding and distant tissues, and it is the most critical problem in cancer treatment. Our group developed cancer stem cells (CSCs) from indu…
View article: Method to Convert Stem Cells into Cancer Stem Cells
Method to Convert Stem Cells into Cancer Stem Cells Open
The cancer stem cell (CSC) hypothesis suggests that tumors are sustained exclusively by a small population of the cells with stem cell properties. CSCs have been identified in most tumors and are responsible for the initiation, recurrence,…
View article: PB1992 HEMATOPOIETIC LIKE CELLS DERIVED FROM CANCER STEM CELLS GENERATED FROM MOUSE INDUCED PLURIPOTENT STEM CELLS: NOVEL CONCEPT FOR CANCER ASSOCIATED HEMATOPOIESIS
PB1992 HEMATOPOIETIC LIKE CELLS DERIVED FROM CANCER STEM CELLS GENERATED FROM MOUSE INDUCED PLURIPOTENT STEM CELLS: NOVEL CONCEPT FOR CANCER ASSOCIATED HEMATOPOIESIS Open
Background: Cancer stem cells (CSCs) represent the subpopulation of cancer cells with plasticity to differentiate into other cell phenotypes. Previously, we reported to generate cancer stem cells from mouse induced pluripotent stem cells w…