M. Saletti
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View article: Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase‐2 Inhibitor
Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase‐2 Inhibitor Open
Owing to the importance of tracing new routes in the development of macromolecular prodrugs, in the present work, two potential macromolecular ester prodrugs (i.e., 12a and 13a ) of selective cyclooxygenase‐2 (COX‐2) inhibitor 7b are desig…
View article: Evaluation of a New Riluzole‐Based Compound <scp>VA945</scp> on Sodium and Potassium Conductances Expressed by <scp>SH</scp> ‐ <scp>SY5Y</scp> ‐ Derived Neurons
Evaluation of a New Riluzole‐Based Compound <span>VA945</span> on Sodium and Potassium Conductances Expressed by <span>SH</span> ‐ <span>SY5Y</span> ‐ Derived Neurons Open
Riluzole (Rilutek), a derivative of benzothiazole, acts as a neuroprotective agent by inhibiting voltage‐dependent sodium (Na + ) and delaying rectifier potassium (K + ) currents. By doing so, it helps reduce excitotoxicity, a key pathogen…
View article: Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita–Baylis–Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity
Synthesis and Reactivity of Oligo(ethylene glycol)-Tethered Morita–Baylis–Hillman Dimers in the Formation of Macrocyclic Structures Showing Remarkable Cytotoxicity Open
Background/Objectives: Crown ethers have received increasing interest owing to their ability to form stable complexes with cations. This molecular feature has been successfully exploited in the development of biologically relevant ionophor…
View article: Crosslinking by Click Chemistry of Hyaluronan Graft Copolymers Involving Resorcinol-Based Cinnamate Derivatives Leading to Gel-like Materials
Crosslinking by Click Chemistry of Hyaluronan Graft Copolymers Involving Resorcinol-Based Cinnamate Derivatives Leading to Gel-like Materials Open
The well-known “click chemistry” reaction copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) was used to transform under very mild conditions hyaluronan-based graft copolymers HA(270)-FA-Pg into the crosslinked derivatives …
View article: Reactivity of a Morita–Baylis–Hillman Adduct Derivative Bearing a Triphenylamine Moiety with Lysine Models
Reactivity of a Morita–Baylis–Hillman Adduct Derivative Bearing a Triphenylamine Moiety with Lysine Models Open
The reactivity of Morita–Baylis–Hillman Adduct (MBHA) derivative 7 was studied with different primary amine derivatives such as n ‐butylamine, Nα‐acetyl‐ L ‐lysine methyl ester, and a poly‐( L ‐lysine) derivative as lysine models to obtain…
View article: Preparation of Light‐responsive Unnatural RNA Bases via a Chromogenic Morita‐Baylis‐Hillman Adduct Path
Preparation of Light‐responsive Unnatural RNA Bases via a Chromogenic Morita‐Baylis‐Hillman Adduct Path Open
RNA‐based tools for biological and pharmacological research are raising an increasing interest. Among these, RNA aptamers whose biological activity can be controlled via illumination with specific wavelengths represent an important target.…
View article: A Facile Access to Green Fluorescent Albumin Derivatives
A Facile Access to Green Fluorescent Albumin Derivatives Open
A Morita‐Baylis‐Hillman Adduct (MBHA) derivative bearing a triphenylamine moiety was found to react with human serum albumin ( HSA ) shifting its emission from the blue to the green‐yellow thus leading to green fluorescent albumin ( GFA ) …
View article: Cross-Linked Hyaluronan Derivatives in the Delivery of Phycocyanin
Cross-Linked Hyaluronan Derivatives in the Delivery of Phycocyanin Open
An easy and viable crosslinking technology, based on the “click-chemistry” reaction copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click-crosslinking), was applied to graft copolymers of medium molecular weight (i.e., 270 kDa)…
View article: CCDC 2286050: Experimental Crystal Structure Determination
CCDC 2286050: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity Open
The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one target-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias. Re…
View article: Investigation on Novel E/Z 2-Benzylideneindan-1-one-based Photoswitches with AChE and MAO-B Dual Inhibitory Activity
Investigation on Novel E/Z 2-Benzylideneindan-1-one-based Photoswitches with AChE and MAO-B Dual Inhibitory Activity Open
The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one tar-get-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias. R…
View article: CCDC 2213739: Experimental Crystal Structure Determination
CCDC 2213739: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Spontaneous polymerization of benzofulvene monomers bearing a 4-Pyridylacetylene substituent in different positions of the benzofulvene scaffold
Spontaneous polymerization of benzofulvene monomers bearing a 4-Pyridylacetylene substituent in different positions of the benzofulvene scaffold Open
Two benzofulvene derivatives bearing a 4-pyridylacetylene substituent in different positions (i. e. 2 and 6) of the benzofulvene scaffold are designed and synthesized to evaluate the effects on the spontaneous solid-state polymerization of…
View article: A tri(ethylene glycol)-tethered Morita–Baylis–Hillman dimer in the formation of macrocyclic crown ether-paracyclophane hybrid structures
A tri(ethylene glycol)-tethered Morita–Baylis–Hillman dimer in the formation of macrocyclic crown ether-paracyclophane hybrid structures Open
A tri(ethylene glycol)-tethered MBHA dimer was synthesized and found to react with n -butylamine leading to the formation of macrocyclic crown ether-paracyclophane hybrid structures that could be modulated by light.
View article: CCDC 2162091: Experimental Crystal Structure Determination
CCDC 2162091: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Design, Synthesis and Characterization of a Visible‐Light‐Sensitive Molecular Switch and Its PEGylation Towards a Self‐Assembling Molecule
Design, Synthesis and Characterization of a Visible‐Light‐Sensitive Molecular Switch and Its PEGylation Towards a Self‐Assembling Molecule Open
HBDI‐like chromophores represent a novel set of biomimetic switches mimicking the fluorophore of the green fluorescent protein that are currently studied with the hope to expand the molecular switch/motor toolbox. However, until now member…
View article: Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers Open
An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium mo…
View article: Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria
Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria Open
Translocator protein 18 kDa [TSPO or peripheral-type benzodiazepine receptor (PBR)] was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions. In these areas, binding sites for TSPO ligands wer…