Mahendran Sekar
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View article: Exploring the Inhibitory Potential of Podolactone B against Human Acetylcholinesterase: A Docking Study
Exploring the Inhibitory Potential of Podolactone B against Human Acetylcholinesterase: A Docking Study Open
In this work, a novel therapeutic drug for treating Alzheimer's disease is molecularly simulated. The cholinergic hypothesis is the treatment approach used in this investigation. With a substance derived from the natural podocarpus derivat…
View article: Molecular Docking and Molecular Dynamics of Asiaticoside and Neoandrographolide as hDHFR Inhibitors for Breast Cancer Prevention
Molecular Docking and Molecular Dynamics of Asiaticoside and Neoandrographolide as hDHFR Inhibitors for Breast Cancer Prevention Open
Breast cancer is the most prevalent cancer among women worldwide and is often associated with the overexpression of nuclear receptors. Despite advances, effective treatments to curb breast cancer cell proliferation remain limited. Human di…
View article: Network Pharmacology of Natural Polyphenols for Stroke: A Bioinformatic Approach to Drug Design
Network Pharmacology of Natural Polyphenols for Stroke: A Bioinformatic Approach to Drug Design Open
This study highlights the neuroprotective role of selected polyphenols through the PI3K/Akt pathway. Further studies are required to investigate additional molecular mechanisms between the polyphenols and their derivatives against patholog…
View article: Advanced Drug Delivery Strategies to Overcome Solubility and Permeability Challenges: Driving Biopharmaceutical Advancements Toward Commercial Success
Advanced Drug Delivery Strategies to Overcome Solubility and Permeability Challenges: Driving Biopharmaceutical Advancements Toward Commercial Success Open
Oral drug administration is the safest and most convenient route for drug delivery. Nevertheless, solubility and permeability are two major issues regarding drug design; these issues must be addressed to overcome the biopharmaceutical chal…
View article: Probiotics and Synbiotics: Applications, Benefits, and Mechanisms for the Improvement of Human and Ecological Health
Probiotics and Synbiotics: Applications, Benefits, and Mechanisms for the Improvement of Human and Ecological Health Open
This review explores the multifaceted roles and applications of probiotics, emphasizing their significance in maintaining and enhancing host health through microbial interactions. It includes the concept of holobionts and the symbiotic rel…
View article: Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae <i>Sargassum ilicifolium</i> (Turner) C. Agardh: Regulation of cytokine cascade
Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae <i>Sargassum ilicifolium</i> (Turner) C. Agardh: Regulation of cytokine cascade Open
Seaweeds have been utilized as food, fodder, fertilizer, and medicine since ancient times; nevertheless, they have received only a little attention. In the current work, we extracted the sulfated polysaccharide from a marine source and inv…
View article: Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology
Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology Open
Background: Rosmarinic acid (RA) is a polyphenol abundantly found in culinary herbs like Rosemary, sage, perilla, and Tulsi, and it has varied therapeutic potential. It is an ester of caffeic acid and 3,4—di hydroxyphenyl lactic acid. It's…
View article: Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis
Exploring the Connections: Autophagy, Gut Microbiota, and Inflammatory Bowel Disease Pathogenesis Open
Inflammatory Bowel Disease (IBD), which includes Crohn's disease and ulcerative colitis, represents a complex and growing global health issue with a multifaceted origin. This review delves into the intricate relationship between gut microb…
View article: Reviewing the literature of 3D printing of bones and cartilage: Evidence and practice
Reviewing the literature of 3D printing of bones and cartilage: Evidence and practice Open
The cutting-edge innovations offer diverse opportunities in medicine; one such inductive approach is 3D bio-printing, in which cells and desired biomaterials cohesively synthesize living macro tissues. The rapidly increasing demand for rec…
View article: Establishing network pharmacology between natural polyphenols and Alzheimer’s disease using bioinformatic tools – An advancement in Alzheimer’s research
Establishing network pharmacology between natural polyphenols and Alzheimer’s disease using bioinformatic tools – An advancement in Alzheimer’s research Open
Alzheimer's disease (AD) is a major cause of disability and one of the top causes of mortality globally. AD remains a major public health challenge due to its prevalence, impact on patients and caregivers, and the current lack of a cure. I…
View article: Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development Open
Decursin is a pyranocoumarin compounds which are rare secondary metabolic plant products, isolated from the roots of Angelica gigas (A. gigas). The native Korean species Angelica gigas Nakai (AGN) is widely used as a remedy for a variety o…
View article: Emotionally Intelligent Next-Generation Touch-Controlled Prosthetic Hand
Emotionally Intelligent Next-Generation Touch-Controlled Prosthetic Hand Open
The research aims to develop an affordable and functional prosthetic hand with tactile feedback capabilities, addressing the challenges faced by individuals with upper limb differences. Through the integration of advanced sensing technolog…
View article: Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials
Lawsone Unleashed: A Comprehensive Review on Chemistry, Biosynthesis, and Therapeutic Potentials Open
Lawsone, a naturally occurring organic compound also called hennotannic acid, obtained mainly from Lawsonia inermis (Henna). It is a potential drug-like molecule with unique chemical and biological characteristics. Traditionally, henna is …
View article: Probiotics and its Application in Humans: An Overview
Probiotics and its Application in Humans: An Overview Open
Probiotics are live microorganisms that have been identified as natural alternatives to antibiotics, which are typically used to treat bacterial infections causing many diseases in both humans and animals. It discusses the benefits and dra…
View article: Chronic Kidney Disease: Etiology, Pathophysiology, and Management Strategies to Increase Quality of Life
Chronic Kidney Disease: Etiology, Pathophysiology, and Management Strategies to Increase Quality of Life Open
Chronic kidney disease (CKD) refers to a variety of pathophysiologic conditions linked to poor kidney function and persistent reduction in glomerular filtration rate. According to the National Kidney Foundation’s guidelines, CKD can be cla…
View article: Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers
Preclinical Therapeutic Effects of Quercetin on Gastrointestinal Cancers Open
Gastrointestinal (GI) cancers were included in the top 10 most common cancers in 2020. Future incidences are expected to rise due to the varying risk factors and aetiologies. With high incidences and mortality rates, current cancer treatme…
View article: Haloperidol-induced painless legs and moving toe syndrome in a schizophrenia patient: a case report
Haloperidol-induced painless legs and moving toe syndrome in a schizophrenia patient: a case report Open
Painless legs and moving toe syndrome (PoLMT) is a rare syndrome characterized by involuntary movements of the toe without pain. The exact etiology of the patient's PoLMT is unknown. We present a case of PoLMT in 45-year-old woman with a h…
View article: Pharmacological Management of Tuberculosis, Challenges, and Potential Strategies
Pharmacological Management of Tuberculosis, Challenges, and Potential Strategies Open
Tuberculosis (TB) is an infection caused by the pathogen Mycobacterium tuberculosis. The disease causes around 2 million deaths worldwide, and incidences of drug resistance only makes increases the number. The most vulnerable victims of TB…
View article: Reliability and Validation of MSCEIT to Evaluate Emotional Intelligence for Chronic Kidney Disease Patients
Reliability and Validation of MSCEIT to Evaluate Emotional Intelligence for Chronic Kidney Disease Patients Open
OBJECTIVE: To evaluate the reliability and validate the method used to test for emotional intelligence (EI) among CKD patients. METHODOLOGY: This study was conducted in a public hospital for patients with kidney disease. A total of 30 CKD …
View article: The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review
The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review Open
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of m…
View article: Corrigendum: Stylopine: a potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy
Corrigendum: Stylopine: a potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy Open
[This corrects the article DOI: 10.3389/fphar.2023.1150270.].
View article: Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence
Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence Open
Cognitive disorders and dementia largely influence individual independence and orientation. Based on the Alzheimer's Disease International (ADI) estimation, approximately 75% of individuals with dementia are undiagnosed. In fact, in some l…
View article: A non-tactile ATM design to tackle the Covid19 pandemic spreads
A non-tactile ATM design to tackle the Covid19 pandemic spreads Open
In 2019, an intense pandemic started gripping the world, and people had been affected a lot. It is essential to maintain a safe touchless transaction in ATMs. This project includes a smart card and GSM technology with the existing prototyp…