Mitsugu Sekimoto
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View article: Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models
Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models Open
Oxaliplatin is an anticancer drug used to treat colorectal and gastric cancers. In many cases, chemotherapy is discontinued due to adverse events caused by anticancer drugs. To address this challenge, we developed a sustained-release drug …
View article: Preoperative diagnosis of ileal duplication cyst in an adult using dynamic imaging and treatment with single-incision laparoscopic surgery
Preoperative diagnosis of ileal duplication cyst in an adult using dynamic imaging and treatment with single-incision laparoscopic surgery Open
We report a rare case of an ileal duplication cyst diagnosed preoperatively in a 72-year-old woman who presented with incidental hematuria. Imaging studies including abdominal ultrasonography and magnetic resonance imaging (MRI) revealed a…
View article: Adult Cystic Intestinal Duplication of the Ileum Laparoscopically Resected after Preoperative Diagnosis with Cine Magnetic Resonance Imaging and Abdominal Ultrasound: A Case Report
Adult Cystic Intestinal Duplication of the Ileum Laparoscopically Resected after Preoperative Diagnosis with Cine Magnetic Resonance Imaging and Abdominal Ultrasound: A Case Report Open
This case highlights the utility of cine MRI and ultrasonography in the preoperative diagnosis of small bowel duplication cysts. In particular, cine MRI provides dynamic visualization of peristaltic movements within the cyst, enabling a co…
View article: Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer
Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer Open
Background and objectives: There has been a steady increase in the use of minimally invasive surgery, including conventional multiport laparoscopic surgery (MLS) and single-site laparoscopic surgery (SLS) for colorectal cancer. We aimed to…
View article: Spontaneous high clonal expansion of Wilms’ tumor gene 1 (WT1)-specific cytotoxic T-lymphocytes in patients with WT1-expressing solid tumor
Spontaneous high clonal expansion of Wilms’ tumor gene 1 (WT1)-specific cytotoxic T-lymphocytes in patients with WT1-expressing solid tumor Open
Wilms’ tumor protein 1 (WT1)-targeted immunotherapy has been used in patients with leukemia and solid tumors. However, the spontaneous WT1-specific immune response before WT1 peptide vaccination in patients with WT1-expressing tumors (PTs)…
View article: Giant hemorrhagic pancreatic pseudocyst with suspected cystic pancreatic tumor: a case report
Giant hemorrhagic pancreatic pseudocyst with suspected cystic pancreatic tumor: a case report Open
Pancreatic pseudocysts are surrounded by a non-epithelialized wall confined to the pancreas and localized to the pancreatic tissue or adjacent pancreatic cavity. In contrast, pancreatic cystic tumors occur less frequently than solid lesion…
View article: Analysis of the clinicopathological features of tailgut cyst with emphasis on the development of neoplastic lesions
Analysis of the clinicopathological features of tailgut cyst with emphasis on the development of neoplastic lesions Open
Tailgut cyst is a rare congenital cyst occurring in the retrorectal space and development of neoplastic lesions in tailgut cyst has been reported. Due to the rarity of the tumor, the histogenesis of neoplastic lesions in tailgut cyst has r…
View article: Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review
Appendiceal Metastasis of Breast Cancer: A Case Report and a Literature Review Open
Appendiceal metastases of breast cancer (BC) are very rare, and there are few reports of resection. Asymptomatic appendiceal enlargement is often suspected to be a primary appendiceal tumor, making it difficult to suspect metastatic tumors…
View article: Photodynamic therapy with paclitaxel-encapsulated indocyanine green-modified liposomes for breast cancer
Photodynamic therapy with paclitaxel-encapsulated indocyanine green-modified liposomes for breast cancer Open
Background Photodynamic therapy (PDT) involves the administration of a photosensitizing agent and irradiation of light at an excitation wavelength that damages tumor cells without causing significant damage to normal tissue. We developed i…
View article: Prognostic scoring system based on indicators reflecting the tumor glandular differentiation and microenvironment for patients with colorectal cancer
Prognostic scoring system based on indicators reflecting the tumor glandular differentiation and microenvironment for patients with colorectal cancer Open
Prognostic stratification is an urgent concern for patients with colorectal cancer (CRC). The desmoplastic reaction (DR) is speculated to mirror the tumor microenvironment. DR types are considered independent prognostic indicators in CRC, …
View article: Optimizing The Timing of Diverting Coloostomy During Sphincter-Preserving Surgery for Rectal Cancer
Optimizing The Timing of Diverting Coloostomy During Sphincter-Preserving Surgery for Rectal Cancer Open
Senolytics and Anti-Aging TherapiesPharmacology is increasingly moving towards personalized medicine, where treatments are tailored to an individual's genetic makeup and health profile.This allows for more precise
View article: Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma
Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma Open
Sarcomatoid hepatocellular carcinoma (SHCC) is a rare and highly lethal subtype of HCC. The present study aimed to explore the unique markers of SHCC using whole gene expression analysis. Subsequently, gene expression analysis was performe…
View article: Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy
Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy Open
A standardized extract of cultured Lentinula edodes mycelia (ECLM, AHCC®) has been shown to have beneficial effects on organ metabolism. ECLM has been indicated to have liver protective properties by suppressing inflammatory responses. The…
View article: Sulforaphane Is Protective against Warm Ischemia/Reperfusion Injury and Partial Hepatectomy in Rats
Sulforaphane Is Protective against Warm Ischemia/Reperfusion Injury and Partial Hepatectomy in Rats Open
Sulforaphane (SFN) has various beneficial effects on organ metabolism. However, whether SFN affects inflammatory mediators induced by warm hepatic ischemia/reperfusion injury (HIRI) is unclear. To investigate the hepatoprotective effects o…
View article: Oncological role of surgical resection in patients with pancreatic ductal adenocarcinoma with liver-only synchronous metastases in a single-center retrospective study
Oncological role of surgical resection in patients with pancreatic ductal adenocarcinoma with liver-only synchronous metastases in a single-center retrospective study Open
Conversion surgery, but not UpS/short NAC, may enhance survival in patients with synchronous liver metastases and favorably anatomical, biological and conditional responses to systemic chemotherapy.
View article: Development of novel prognostic score based on the indicators reflecting the tumor glandular differentiation and microenvironment for patients with colorectal cancer
Development of novel prognostic score based on the indicators reflecting the tumor glandular differentiation and microenvironment for patients with colorectal cancer Open
Purpose: Development of prognostic stratification in patients with colorectal cancer (CRC) is an urgent concern. Desmoplastic reaction (DR) is a tissue reaction, speculated to represent the tumor microenvironment. DR types have been establ…
View article: Switching chemotherapy in neoadjuvant treatment for resectable/borderline resectable pancreatic cancer - New treatment strategy in the era of biological borderline resectable -
Switching chemotherapy in neoadjuvant treatment for resectable/borderline resectable pancreatic cancer - New treatment strategy in the era of biological borderline resectable - Open
Daisuke HASHIMOTO*, Sohei SATOI, Tomohisa YAMAMOTO, So YAMAKI, Hidetaka MIYAZAKI, Yuki MATSUI, Yuki TSYBULSKYI, Mitsugu SEKIMOTO. Ann Hepatobiliary Pancreat Surg 2023;27:S392. https://doi.org/10.14701/ahbps.2023S1.EP-126
View article: Effect of systemic inflammatory response on induction chemotherapy followed by chemoradiotherapy for locally advanced pancreatic cancer: an exploratory subgroup analysis on systemic inflammatory response in JCOG1106
Effect of systemic inflammatory response on induction chemotherapy followed by chemoradiotherapy for locally advanced pancreatic cancer: an exploratory subgroup analysis on systemic inflammatory response in JCOG1106 Open
Objective JCOG1106, a randomized phase II trial conducted to compare chemoradiotherapy (S-1 concurrent radiotherapy) with (Arm B) or without (Arm A) induction chemotherapy using gemcitabine in patients with locally advanced pancreatic canc…
View article: The Prognostic Impact of ABO Blood Group in Hepatocellular Carcinoma Following Hepatectomy
The Prognostic Impact of ABO Blood Group in Hepatocellular Carcinoma Following Hepatectomy Open
Background/Purpose: The effect of the ABO blood group on the survival of patients with hepatocellular carcinoma (HCC) is unclear. The aim of the present study is to determine the prognostic impact of ABO blood types on the survival of a Ja…
View article: Supplementary Figure S2. Reproducible measurement of CEA mRNA by serial dilution of MKN45. from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
Supplementary Figure S2. Reproducible measurement of CEA mRNA by serial dilution of MKN45. from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial Open
The standard curves were plotted using the serial dilution of cDNA from MKN45. We confirmed that the CEA value was reproducibly measured in the range of 1.0x10-1 to 1.0x10-4 with standard deviation < 10% in each dilution.
View article: Supplementary Figure S3. Survival analyses stratified by qRT-PCR (group a vs group b, vs group c+d). from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
Supplementary Figure S3. Survival analyses stratified by qRT-PCR (group a vs group b, vs group c+d). from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial Open
MM-free CRC group (group a, n=90) had a considerably favorable prognosis. (A) 5-year DFS: 5-year DSF was 93.3, 86.5, and 74.7% in group a, group b and group c+d (High-MMV), respectively. (B) 5-year OS: 5-year OS was 97.8, 95.5, and 89.5 % …
View article: Supplementary Figures S8-9. from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial
Supplementary Figures S8-9. from Micrometastasis Volume in Lymph Nodes Determines Disease Recurrence Rate of Stage II Colorectal Cancer: A Prospective Multicenter Trial Open
Figure S8: Survival analyses of the entire CEA　band-positive group.　 Of the entire CEA band-positive cases, 31 cases eventually received post-operative chemotherapy using HCFU for one year, whereas 41 cases had no treatment. There was …